2RBB


Conserved Protein Domain Family
PsjN_like

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cd16356: PsjN_like 
Click on image for an interactive view with Cn3D
Burkholderia Phytofirmans glyoxalase/bleomycin resistance protein/dioxygenase family enzyme and similar proteins
Burkholderia Phytofirmans glyoxalase/bleomycin resistance protein/dioxygenase family enzyme and similar proteins. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319963
View PSSM: cd16356
Aligned: 10 rows
Threshold Bit Score: 139.866
Threshold Setting Gi: 736137182
Created: 30-Dec-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative activehomodimer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Citation:PMID 9218781
  • Comment:Glyoxalase I has two active sites, type I extradiol dioxygenase has only one active site at the C-terminus. Some other members in this superfamily do not have a catalytic site at all. The site annotation is based on the glyoxyalase I.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #   #                              #          # #                         #     
2RBB_A        11 YVNIFTrdiVAXSAFYqqvfGFQEIesir---spiFRGLdtgksCIGFNaheayelxqla----qfsetsgikfLLNFDV 83
gi 21218853    5 QPVILTadhDVLVDFYtklfGAEEIfrvpekgpvfYLGLrigdtDLGLVakpdpgd------------reapriLLSINV 72
gi 28870157    6 YVNVFAqdiVALSGFYsklfGFSEIeair---spiFRGLdtgksCIGFNaldayellgld----eftdstgcrfLLNIDV 78
gi 945109206   5 YVNVFTkdiVSLSGFYrdlfGFEEIpdir---spiFVGLrtgqsCLGFNaqdaydllglg----efsgptgikfLLNIDV 77
gi 516072212   6 YTNIFTadiDRLADFYsslfGLEEYresr---spiFRGFaaggtSLGFSgtgayellgm-----apqtepgdrvFQTFNV 77
gi 491348482  10 FVSIICsdfISQASFYgtvfSLPEIeela---sehFRALrvggtTLGFHtpgalellslp---petiigdssasFWTFET 83
gi 736137182   9 QPVLCSndvPRLRAFYsdlfGAEQTfrmpdegdafFIGLrvgssDLGIVadeqgaa------------aqpgriIVTVFV 76
gi 523658216   8 FASVIAddiVALSSFYaevfGLDEVtelr---sehFRGLrlgdtILGFStshayqllnlt----pprdtsgttsFITVEV 80
gi 882840793   6 YVNVFArdiEALSGFYrelfGFRNIpeia---spiFRGLdtgksCIGFNape-------------------ayeLLQLDA 63
gi 518404583   4 WFNLFTpdpQALLDFYqallGLPEAvasr---spiYRALetadfQLGFNarpaydllglperapalgsvppvtaYCTFML 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
Feature 1                                          #       # # 
2RBB_A        84 DTkeavDKLVPVAIAAGatlikapyetyyhwyqAVLLDPeRNVFRI 129
gi 21218853   73 DDv---DETLGRVAALGgtvrrgpndmpwgqrvAHIQDPdGNPVNL 115
gi 28870157   79 EEqsdvDRLVPQAVALGarlvkepyltyyhwyqAVLLDPeGNIFRI 124
gi 945109206  78 DQpedvDRLVPVAVSMGarlikppyttyynwyqAVLLDPeGNVFRI 123
gi 516072212  78 DSpeevQRLTRQAAVLGaqvvkepfetyygwyqSVLRDPdGNAFRI 123
gi 491348482  84 ADeaavDTLVADALTAGatlvkapyltyygarqAVLRDPeGNVFRI 129
gi 736137182  77 DNv---DDLLPKVEAAGgtligpandmpwghrvAHVADPdGNPVNI 119
gi 523658216  81 DDepsvDRLTTAAVAIGarcvagptrtyyrawqSVLLDPeGNAFRI 126
gi 882840793  64 FA----DALGARLIKAPyetyy-------hwyqAVLLDPeDNVFRI 98
gi 518404583  81 DTadavSRCAERVAALGgrlikppyptyygqwqAVLADPqHNVFRL 126

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