Conserved Protein Domain Family
VOC_BsCatE_like_C

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cd16359: VOC_BsCatE_like_C 
C-terminal of Bacillus subtilis CatE like protein, a vicinal oxygen chelate subfamily
Uncharacterized subfamily of vicinal oxygen chelate (VOC) superfamily contains Bacillus subtilis CatE and similar proteins. CatE is proposed to function as Catechol-2,3-dioxygenase. VOC is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319966
View PSSM: cd16359
Aligned: 14 rows
Threshold Bit Score: 111.308
Threshold Setting Gi: 222420152
Created: 6-Jan-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 499402541 209 GHMHLRVGDLAQAENFYHgtVGLDPTrkr-ngAAFLSSGRYHHHLGMNVWqsqgaglrddsTTGLAWFSlvmakqellaa 287
gi 116494648 172 GYVQFRVSDLPATSHYLEqgLGFREKtsrdpnEVFLAAGDYRHHIGINLRldaklalptpdMYGLDYVSfilpdqhamen 251
gi 22538215  170 GHIHLSVKDAKISSKLYQnvFGLDEKfai-ptASWIASGNYHHHLAFNNWagpnlsknqedRPGISLLTiaynddnlfrd 248
gi 125718390 207 GHVHLSVKNSRAASHFYQklLGLEDKfsv-psASWLASGNYHHHLAVNEWggshlnhrqpkQLGLAYFEaqvegkedlva 285
gi 15964739  185 GHIHLQVSDIPQADAFFRdaLGLDLMary-pgASFFATGKYHHHVAANIWnsrgapkrqgnMTGLADYTirfrepaalaa 263
gi 30021634  192 GHVHLRIADVEKSHEFYVetVGFEVQqre-edCLFISAGGYHHHIGANTWngvnnphppvhATGLKVYTivlpykealde 270
gi 15806765  180 GHVHLKVGHAAEAAQFYRavLGLEVVshl-pgAAFLSWGGYHHHLGLNEWhtrgqghpeapAAGLSGFEvrtpdlaplr- 257
gi 222420152 169 GHLHLKAYDLKASSQFYKq-MGFQITsvl-pkALFLSEQKYHHHIAINTWqsnqplrnpeqTYGLTAFNiide------- 239
gi 262335464 164 GHLHLHVPDLDEAERFFAgrLGMTVTlrtypgARFFAYDGYHHHVGANIWargrr--apehATGLLAYTlqvpea----- 236
gi 27382384  209 GHMHLRVGDLAQAENFYHgtVGLDPTrkr-ngAAFLSSGRYHHHLGMNVWqsqgaglrddsTTGLAWFSlvmakqellaa 287
                         90       100       110
                 ....*....|....*....|....*....|....
gi 499402541 288 qee---rlrksgvkvtaladGLEAVDPWGTRVRL 318
gi 116494648 252 ilmnldaagltdydynkdnqFLMIAGPNRLTLWF 285
gi 22538215  249 slkk--aqlyqltflekqdhYYIIEDFDGIRIKV 280
gi 125718390 286 iyen--aldlqapvrwissqELEVTDPDGIVAKV 317
gi 15964739  264 air---kldaleiavdrqgdAHSLTDPWGIGLKL 294
gi 30021634  271 vke---rliekqheinettnGFVVVDPSGITVQF 301
gi 15806765  258 ----------eeggwedlgdALRRADPWGNVVTV 281
gi 222420152 240 -----------------nkkSEVYTTLEGLKLTI 256
gi 262335464 237 ---------------iartlPPALQDPAGITVHI 255
gi 27382384  288 qee---rlrksgvkvtaladGLEAVDPWGTRVRL 318
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