Conserved Protein Domain Family
VOC_ShValD_like

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cd16361: VOC_ShValD_like 
vicinal oxygen chelate (VOC) family protein similar to Streptomyces hygroscopicus ValD protein
This subfamily of vicinal oxygen chelate (VOC) family protein includes Streptomyces hygroscopicus ValD protein and similar proteins. ValD protein functions in validamycin biosynthetic pathway. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319968
View PSSM: cd16361
Aligned: 11 rows
Threshold Bit Score: 163.656
Threshold Setting Gi: 84872453
Created: 12-Jan-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32472759    6 TFSHIGLSVTDLDAAVEFYTQTLGWYVIMppteivsddsaigv----mcndvfgegwgrfRIAHLSTGDKiGVEIFEFKN 81
gi 119393695  11 AVHHVAYTVPDLDQAVEFFTEVIGAELAYtlvqdaagdwmt--------rkldvdatataRIAMLRLGPVtNLELFEYAA 82
gi 27383300   39 GVNHIGITVPDIEAAKSFLVQAFGGQVIYqsfgpqdpprqgpe---feravgafpgtvvrGQAMVKIGTGpDIELFEMHG 115
gi 38638558    5 AIEHVGITVPDMEQATRFFCDAFGAQVIYdmldqplggpeve------aglgvpsgsvirAIRMLRLGNGpNLELFTYAG 78
gi 28899963    2 KMNHVGIMVGDMDKAVEFYTQALGLKVVMgntkvveeretaig---rmciavfgegfkgfNIAHLVTSDGiGLELFEMKE 78
gi 219678145   4 KVDHVSLTVEDIDEAIEFYTRVMGAELRYrmgpfdareiprgedgrdwtdahvqvpdarlNIAMLKLCENlGMELFQYDR 83
gi 84872453  146 GVDHFARTVADLDSAERFFVDVLGAEPLYrseygalpedva--------aalgvppggamRRAVLGMGPTdTIELASYQG 217
gi 206685535   7 TFSHIGLSVPDLEAAVKFYADVMGFYVLMqpsevteddsaigq----mctdvfgpgwtrlRIAHLSTADGiGIELFEFDG 82
gi 169628139   2 SVNHVGITVPDIAAAIDWYRDVFGFECVMgprtlepgpage-------lppgldarfgqaRMAGLQTANGvGVELFEFID 74
gi 222422513   6 GINHIGLTVPDIEAATEFFKKGLNGKIAYdsqtemesprgged---verylgledgakiiKKRMLVFGNGpNIEMFEFAN 82
gi 76262893   41 RVDHLAFTVSDLDAAIDFAVMALGGELVYrlpplahtdgwm-------rthldvhprasaEIALVRLGPDtNLELFAYKS 113
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 32472759   82 AEKpkdnf---eywktGVFHFCVQDPDVEGLAKRIVANGGkqrmpvre---yfpgekpyRMVYCEDPFGNIIEIYSHS 153
gi 119393695  83 PDQrrqlp---rnsdwGGHHLAIHVADVDAAAEYLRAQPGvrvlgdpet-itdgpiagdRWVYFATPWGMQLELINLP 156
gi 27383300  116 PQQaqpir----asdfGITHFGVYTDDIDASVTRFEKAGGtrltapraipyatekglgnKVCYCRMPWGTTMEFITTP 189
gi 38638558   79 VEQappvr----psdfGIQHFCIYVDDIDAAAERLQQAGGkllsqpgnl-pggdagegnRYVYTRTPWGSTIELVTYP 151
gi 28899963   79 RQArhevd----fsriGIFHFCLQTDDFEGAIKRTEAFGGkvrmdimry-hpeddnkpaKMVYLEDPFGNLFELYSHT 151
gi 219678145  84 PEDaatvpp--rncdvGARHICLQVDDVEAAINYLAENGCsamagpivs--eggpapdsLSWYVTDPFGHQMELVQYT 157
gi 84872453  218 KSAgnprpp--rnsdvGGSHIALHVRDVDAAAAYLAAHGCtvlgrpeti--degpltgdRWVYTRAPCGLYVEVVRMP 291
gi 206685535  83 NEApqdnf---qyrkhGTFHFAVQDPDVEGLLEKIVAAGGkqrmpvre---yfpgekpyRMVYVEDPFGIIFELYSHS 154
gi 169628139  75 PVTdpppevpveytrrGTWHLCLTVSDVERQTRSVAAAGGrvitaprr----vvsgrpwTMSYLTDPWGTVIELMSHD 148
gi 222422513  83 AQQrsaes----lqdiGFTHIAFYVDNFESALEQVIEAGGepisephfn-tryedtsgnQTVYIKAPWGSLIELQTVP 155
gi 76262893  114 PDHtaapr---aphdtGHVHLALHVTDVARAAAELTRRAGvsplgpvlrvpdgqpdagtHWVRLSSPFDAPLELRSVP 188
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