3PKV,3OUL,3OPY,3PKX


Conserved Protein Domain Family
TflA

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cd16362: TflA 
Click on image for an interactive view with Cn3D
Toxoflavin Lyase
Toxoflavin lyase (TflA) is metalloenzyme degrading toxoflavin at the presence of oxygen, Mn(II), and dithiothreitol. TflA is structurally homologous to proteins of the vicinal oxygen chelate superfamily. The structure of TflA contains fold that displays a rare rearrangement of the structural modules indicative of domain permutation. Moreover, unlike the 2-His-1-carboxylate facial triad commonly utilized by vicinal oxygen chelate dioxygenases and other dioxygen-activating non-heme Fe(II) enzymes, the metal center in TflA consists of a 1-His-2-carboxylate facial triad. Toxoflavin is an azapteridine that is toxic to various plants, fungi, animals, and bacteria.
Statistics
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PSSM-Id: 319969
View PSSM: cd16362
Aligned: 6 rows
Threshold Bit Score: 118.471
Threshold Setting Gi: 308198670
Created: 12-Jan-2016
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
metal bindingchemical
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 2 residue positions
Conserved feature residue pattern:H EClick to see conserved feature residue pattern help
Evidence:
  • Structure:Paenibacillus polymyxa toxoflavin-degrading enzyme with bound Mn, contact 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
3PKV_A       28 KQLTLYTAE---LDRMLAFYTNML-GAQHVHEQa--dAFTIq---LGVSQIQFRAAADgtk------------------- 79
3OUL_A        5 KQLTLYTAE---LDRXLAFYTNXL-GAQHVHEQa--dAFTIq---LGVSQIQFRAAADgtk------------------- 56
gi 28170110  20 AAVLVHVPN---VEQGLDWYQKAFpEATPVYHSn--fDFTVl--dLNGFSIEIVQADEkvgsgk---------------- 76
gi 21229805   7 SGLFIYAKD---LERVAAFYQRVL-GMQAIHSSk---ELVV----LNAAALQLVIHAVpeai------------------ 57
3OPY_B       11 SFITLFAPNislLQASIDFYTNFL-GFAIRKNSnqklFWLQleedQNNVSIQLILDPEhaasvsqidqnirnltrslyrk 89
3PKX_A       28 KQLTLYTAE---LDRMLAFYTNML-GAQHVHEQa--dAFTIq---LGVSQIQFRAAADgtk------------------- 79
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1              #                                                                 #     
3PKV_A       80 ----pfYHIAINiaanhfqe-------------gkawlsgfGELLTENDedqayfpffnaySCYVEDPsGNIIELISRQ 141
3OUL_A       57 ----pfYHIAINiaanhfqe-------------gkawlsgfGELLTENDedqayfpffnaySCYVEDPsGNIIELISRQ 118
gi 28170110  77 -ngtvlYWSVNNlskslacfe------------algaklyrGPMEIENGl----------sMCQVEDPfGNLIGLRGKA 132
gi 21229805  58 ---aasITIADPpnrrentalkffftvpsiaqlvelaaalgGEILPAQWrgp------gfvACNAVDPeGNVSQLRERA 127
3OPY_B       90 dwrsiqSNIAFKssslskl---------------vkllkdgGHPVQQSPne--------isPFEVYTV-DPLGSLIGFS 144
3PKX_A       80 ----pfYHIAINiaanhfqe-------------gkawlsgfGELLTENDedqayfpffnaySCYVEDPsGNIIELISRQ 141

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