1H0H,1KQG


Conserved Protein Domain Family
FDH_beta_like

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cd16366: FDH_beta_like 
Click on image for an interactive view with Cn3D
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins
This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.
Statistics
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PSSM-Id: 319888
View PSSM: cd16366
Aligned: 10 rows
Threshold Bit Score: 234.986
Threshold Setting Gi: 28948358
Created: 15-Jan-2016
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Fe-S cluster
Conserved site includes 40 residues -Click on image for an interactive view with Cn3D
Feature 1:Fe-S cluster binding site [ion binding site]
Evidence:
  • Structure:1KQG: Escherichia coli formate dehydrogenase N binds to 4[Fe-S] clusters; contacts at 4A distance.
    View structure with Cn3D
  • Structure:1H0H: Desulfovibrio gigas formate dehydrogenase binds to 3[Fe-S] clusters; contacts at 4A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #      #### ##   #   #                         # #                        #  ###
1H0H_B         4 FFVDTTRCTACrGCQVACKQWHgnpatptentg-fhqnppdfnfhTYKLVRMHeqeidg--------ridwlFFPDQCRH 74
1KQG_B        32 KLIDVSTCIGCkACQVACSEWNdirdevghcvg-vydnpadlsakSWTVMRFSeteqng--------klewlIRKDGCMH 102
gi 488706664   6 FFTDTTICIGCkACEVACKQWNqlpedgleltgmsydntghlgasTWRHVAFVerpvpmpghtvglvdfswlMSSDVCKH 85
gi 495688105   5 VLVDITRCMGCkACQVACKQWNdlpsgvpefke-gltsppemngyTYTTVRIEvvekan--------dytmrSAKRQCMH 75
gi 494499368   6 YCYDSSKCVGChGCQVACKQWNeektlatrfa---gsyqnppdldKDTRMVMRyyehfeq-----dtipslnFLKYQCFH 77
gi 320150251   9 ILFDASRCIGCkACQVACKQWNdleaektenrg-syanpprltahTWISMRYYeglrpd-------gdpyfdFIRGSCMH 80
gi 973059588   6 MFIDTSKCTGCrACQVACKNWNglpaeetdfwg-tyenpktltgnTWTKVKFNekveng--------nikllFAKIQCMH 76
gi 296030870   6 ILVDVSKCTGCrGCQVACKQWNnlpatktkfs----gsyenpvtmNGAYTKVKfietven------gqvrflFRKIQCMH 75
gi 931512592   6 MLVDVSKCTACrACQVACKQWNglpaekteqrg-thqnppdltwaTWNLIRFTevptke-------gnlkwlFRRDACLH 77
gi 296925270   6 RLIDITRCTACrGCQVSCKRWNqlpgeigaftg-syqshddlspgRWTMIRFYeekkgr-------gelawhFRKATCMH 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #    #   ##     ##        #           ####   ### ##          # #####            
1H0H_B        75 CiappCKATADmedeSAIIHDdatGCVLFTPKtkdledYESVISACPYDVPRKVae--snQMAKCDMCidrit------n 146
1KQG_B       103 CedpgCLKACPs--aGAIIQYa-nGIVDFQSEnc--igCGYCIAGCPFNIPRLNke--dnRVYKCTLCvdrvs------v 169
gi 488706664  86 CqragCLEACPt---GAIIRTe-fDTVYVQPDvc--ngCGYCVTACPFGVIDRRed--dgRAWKCTLCydrlg------e 151
gi 495688105  76 CehpaCASACFa---KALQKDpktGAVVYHSHlc--vgCRYCMLACPFDIPKYQwdkqfpLVAKCQFCfdpkgkydrlgy 150
gi 494499368  78 CgeaaCVKVCPs---GALFKTk-tGIVAVDREkc--iaCGYCHNACPFNIPAVGk-----HVNKCDMCrsrtengqdgdk 146
gi 320150251  81 CthapCVASCPt---GAMAHRe-gGVVTVDEKtc--igCRSCVQACPYEAVHFDea--rgVVHKCTMCydris------n 146
gi 973059588  77 CndasCMAVCAt---KAISRRp-gGMIVIDQNrc--vgCRNCVTACPFGAVNFSee--tgTPRKCRLCedrva------a 142
gi 296030870  76 CteasCMAVCAa---GAISRAd-nGQVVIDRDtc--igCKNCVVACPFGAIGFDee--tgTSGKCWGCqdrve------n 141
gi 931512592  78 CtdagCMRACPv--pGAIFRTp-qGAVVINQElc--igCKMCVNACPFEIPRINae--tnRAYKCTLCwdrta------r 144
gi 296925270  78 CgdagCLKACPn---EALVQEe-nGTIRRIEEnc--igCGHCVQFCPFDIPKVDev--aqKMKKCTFCydris------n 143
                        170
                 ....*....|....*...
Feature 1             #   #    #   
1H0H_B       147 glrpACVTSCptgAMNFG 164
1KQG_B       170 gqepACVKTCptgAIHFG 187
gi 488706664 152 gmtpACAKACptaSIQYG 169
gi 495688105 151 glqpACVDTCptgALKFG 168
gi 494499368 147 tnvpACVKTCpagALEFG 164
gi 320150251 147 gdqpACVKACptdALTFG 164
gi 973059588 143 glqpACVNAClsgALNFG 160
gi 296030870 142 gltpACAKTCptgAITFG 159
gi 931512592 145 glipACVKACamgTLTFG 162
gi 296925270 144 grepACAKTCvprAIVYG 161

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