Conserved Protein Domain Family
DMSOR_beta_like

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cd16367: DMSOR_beta_like 
uncharacterized subfamily of DMSO Reductase beta subunit family
This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.
Statistics
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PSSM-Id: 319889
View PSSM: cd16367
Aligned: 19 rows
Threshold Bit Score: 165.558
Threshold Setting Gi: 347586706
Created: 29-Jan-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Fe-S cluster
Feature 1:Fe-S cluster binding site [ion binding site]
Evidence:
  • Comment:predicted based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #      ####  ##   #   #   # #                              #  #### 
gi 516486958 641 FLLGQGVGEASDVLLIDESLCIQC-NNCETACAETHdGTSRLKREa-----------------GPTFANIHLPTACRHC- 701
gi 575418390 605 DMSRYGVVESTDVLLIDETKCIRC-DNCVNACAATHnGQSRLDRKh-----------------GPSFAYVHVPVACRHC- 665
gi 495188526 443 ALVDDGVIEGTEVLVIDLAKCIHC-NECEEACERRH-GHSRMNRN------------------GLVVGNISIATACRQC- 501
gi 163847096 301 MAVNHGLLRAPYVLVRDPARCPPGcRLCETGCATRH-GHARLHLN------------------GTPIDRFDVLDHCRQCs 361
gi 662353119 649 FLVDNGIGEATDVLLIDEHLCVGC-DNCEKACADSHdGLSRLDREa-----------------GRTYAHLHVPTSCRHC- 709
gi 409028466 582 FFDAEQVTNANNLLVIDKDKCVGC-DNCETACAATHnGVSRVNRGq-----------------GGVIANAHLPGSCRHC- 642
gi 148569382 305 AILEHGLRRGTHILVRDLSLCKPGcRICEDACASRH-GAGRIHFS------------------GLTLNGIEIADACRQCr 365
gi 934112925 283 VAVRYGMFRGSHVLVRQPAQCPPDcRICEQACAERF-GQTRMHLN------------------AAKLEEWDITQSCRQCr 343
gi 952343728 298 TLVEKGIIQAESLLIIDLKTCIHC-NNCVDACEDRH-GYPRLDRR------------------GTRVPDVSIPVACRLC- 356
gi 908357694 296 FRDLYRLQVARSLLVIDLDSCVRC-GHCAWACAETHqGVARLIRRgdkiaaqgeaeatdrasvVAAPRSLLLPNSCQHC- 373
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #   ##   ##        #         ####   ### ##                                  
gi 516486958 702 EHPHCMKECP-PDAISRS-EAGEVFISDACI-GCGNCERNCPYGVIQMAsekppkkggglpwllfgl------------- 765
gi 575418390 666 VGAPCLADCPpGDAILRD-EEGVVRINESTCiGCGNCANYCPYGVIFMVeppepawwqrwfgprskaevpaeavtpvvqp 744
gi 495188526 502 QDPVCMLCSR-AGIARLPsGEVYITESCIGCgICAERCPYDNISIVDLEeqqtqrqgdlwqsfstffsskkrkl------ 574
gi 163847096 362 VGAECVEVCP-EDAIERV-DTGALRITNRCT-GCGECVSACPYDAVTSVprtrhstgplwelfrrl-------------- 424
gi 662353119 710 EHPHCMADCP-PNAIHRG-PDGEVFIDDTCI-GCGNCQRNCPYGVIRMDsvppkkpgllswmffgqgpgp---------- 776
gi 409028466 643 QQAYCMQDCP-ADAITRA-PDGSVQISDQCI-GCGNCAQLCPFDAITIAspdsrswldkm-------------------- 699
gi 148569382 366 VGAECVEACP-EDAIVWN-ESGALFITDACN-GCGACVPACPYHAVDMRsiapphqsplwglwqrlq------------- 429
gi 934112925 344 VGAECVEACP-ENAIQWD-DNGALRITDACT-GCNDCVEACPYDAVESQtiylqnqhgplwqlw---------------- 404
gi 952343728 357 HDPVCLICNF-DAIKRAP-TGEINIIDDKCV-GCAGCAIRCPYNVIQMVpskpehelkkfniisallk------------ 421
gi 908357694 374 ENPACMLECP-TGAIGKD-PAGEVFIREALCtGCGACAKACPWDNIQMAprdskvgaqagstrpaas------------- 438
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                  # #####        #   #     #      
gi 516486958 766 --------gkapgqrqadydanapkKAVKCDLCSGlkGGAACVRACPTGAAIRISPED 815
gi 575418390 745 qdsagpcgcetcgaydypqtaehreIAIKCDMCQTlsGGPACVSSCPTGAAIRVKQHE 802
gi 495188526 575 lpvlttpgpldntppldpveeirkkIAVKCDLCAGy-NDQACVQACPTGAAIRVNPRT 631
gi 163847096 425 --------qqrvrpsipltpttpthRADKCDLCFGy-TDLACVTACPIGNLRLAPVEE 473
gi 662353119 777 -----gepskkwryknaepgvekpkKAIKCDMCSGieGGPACVRACPTGAAIRVAPED 829
gi 409028466 700 --------------npfaastkapaVALKCDLCRTrsTGPACVEACPTGAAQRMAPQD 743
gi 148569382 430 --------rwrmpvipletdhqtqqRANKCDLCHGy-NDLACVSACPTGALRLVSVEE 478
gi 934112925 405 -----------qrmqkqsvprqpktVASKCDLCAGy-DDRACLSQCPTGSLQLISVEE 450
gi 952343728 422 ------gakesdnktpkdhkikpkhLAIKCDNCLGy-YDTACTNNCPTNSIKWVNPME 472
gi 908357694 439 -------teltgepgaiasmgrsaeVAVKCDLCRSe-AGPACVQSCPVGAIARVNPAE 488

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