Conserved Protein Domain Family
DMSOR_beta_like

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cd16369: DMSOR_beta_like 
uncharacterized subfamily of DMSO Reductase beta subunit family
This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.
Statistics
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PSSM-Id: 319891
View PSSM: cd16369
Aligned: 13 rows
Threshold Bit Score: 270.028
Threshold Setting Gi: 518363629
Created: 12-Feb-2014
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Fe-S cluster
Feature 1:Fe-S cluster binding site [ion binding site]
Evidence:
  • Comment:predicted based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #      #### ##   #   #     # #              #  ####      #   ##  ##       #  
gi 501180272   7 DQMFVIDQSRCIGCESCVQACEECGThRGQSLIHLEYLDrgantQTAPMVCMHC--EDPTCAEVCPADAIKQNeDGVVQS 84
gi 495082139   9 NEEFFVDMQRCIGCKACELACSECETnGQESMIHVNYIDrattvQTTVQVCMHC--DDPVCANVCPADAISKDeFGIVHT 86
gi 494038470   9 EMEFFMDPQRCIGCHACEMACAECETnGQLPMITVDYVKratspQTVMQICMHC--EDPACAKVCPADAIVKDeFGVVMS 86
gi 551074306   3 EMRFFIDPVRCIGCKACMQACSECSThRGKSMIHLEYIErgsstQTAPMVCMHC--DLPTCAAVCPADAIKRTeDGVVQS 80
gi 568813117   2 NKIMYLEFERCIGCRACQAACRECGDhDAKERNYVEYIDftesrQTFPMMCMQC--KDPACARVCPANAIQITeEGVVLS 79
gi 522212935   3 GYEFYVDPSRCIGCQSCVEACEECEThRGVSMINFDYLDryetaNTAAYVCWHC--EEPTCAMVCPADAIKVGeDGVVRS 80
gi 518363629   2 AKVLYIDFERCIGCRACMIGCEECSGhDRLSRMFVDELNpgetvAASPTPCMHC--VTPACAESCPVQAISVL-DGVVLS 78
gi 498182789   2 KKLLYIEMDNCIGCRSCLAACTQCGGhDERNRNYVYDVNplvdrQTIPLMCLHC--VNPACARSCPAQAIQITeEGAVLS 79
gi 934119074   5 QYEFFIDPSRCIGCQSCVQACSECDThKGQAMIHLEFVNrhystQTAPVVCMHC--DSPTCAEVCPADAIKKTpDGVVQT 82
gi 521004162   6 HLEFFVDPSRCIGCRACVEACTECDThRGESMIHLEYVDrgssvQTVPVVCMHC--EQPTCAEVCPADAIKRTgDGVVQS 83
gi 746991732   2 EETMFIDPRRCIGCRACVSACRECGThKGHSMIFVDYLDrghttATMPTICMHC--VEPTCALVCPADAIKVSeDGVVMT 79
gi 291348391   2 GRTIFIDPGRCIGCQACVSACRECDShRGKSMIHLDYTDegqsvASLPTVCMHCedPVAPCAEVCPADAILVTaDGVVQQ 81
gi 269791287   4 IKTMFVDPSRCIGCRACEAACRECDShKGESMIMVDFIDrglstATQPTICMHCedPVAPCAQVCPVMAILITpEGVVQM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                ####   ### ##        # #####           #   #    #                       
gi 501180272  85 ALKPRCIGCSNCVVACPFGVPKYFAlPDQMMKCDMCYDRTSVGKAPMCASVCPsEALWFGTPAEFEQtrtgellfef-qf 163
gi 495082139  87 ANTERCIGCSNCVMACPFGVPKKEEnYDLMMKCTMCYDRTSVGKKPMCATVCPsGALFYGTREEIQEmrpnstpvn---- 162
gi 494038470  87 ANTSRCVGCSNCVLACPFGVPKKVElSDLMMKCNMCYDRTSVGKRPMCATVCPsGALWYGTREKLERlrpnstpin---- 162
gi 551074306  81 SQSPRCIGCANCVNACPFGVPRYYPeIDQMLKCDMCYDRTSVGLKPMCASVCPsEALFFGTLEEFQSrrhgtpkn----- 155
gi 568813117  80 AMDEKCIGCRNCTFACPFGIPKFDFeENKMYKCDMCYDRSKYDIAPMCASVCPsDAIRFIDFEEMQSl------------ 147
gi 522212935  81 ALKPRCIACSNCVLACPFGIPKIIPeYEQMMKCDMCYDRTSVGKRPMCATVCPsQALSYVKPEQIAKrreeptnl----- 155
gi 518363629  79 ASHEKCIGCKNCTYACPFGIPRVDEkRNLMYKCDLCYDRTSKGRPPMCVSVCPtDTIQFLDEEEARHkrnkpvqy----- 153
gi 498182789  80 ALVEKCIGCQNCTIACPYGIPKFDEeQNLMYKCDLCYDRTKDGIPPMCASVCPtNTLQWIDENELAEkrerhrvgkwvss 159
gi 934119074  83 ARKPRCIACNNCVLACPFGVPKMNSgAELMMKCDMCYDRTSIGKAPMCASVCPsGALYYGTREQIEAqrprsmpvn---- 158
gi 521004162  84 ARKPRCIACGNCVVACPFGVPELYIdRAIMMKCDMCYDRTSVGKKPMCATVCPsQALFFGTREQSIAlrpqsiptn---- 159
gi 746991732  80 AMEPRCLDCRNCVNACPFGVPKYNTaMHLQMKCDLCFDRTAEGLKPMCASVCPtGALTYGRYEEIVPqrrdvrpvn---- 155
gi 291348391  82 ADTTRCIGCSNCVNACPFGVPKIDLqAKLQMKCNLCYDRTAYGLAPMCATVCPtGALFYGTVEELQAerpgvqvad---- 157
gi 269791287  84 ADPSRCIACRNCVYACPFGVPKMDLeSRLMKKCNLCYDRTSQGLQPWCAQACPtDALWYGSYEEFVAerrgravn----- 158
                        170
                 ....*....|....*...
Feature 1                          
gi 501180272 164 grqlvptkVATVVHDTGP 181
gi 495082139 163 sfifgkevVNTKVNIMMP 180
gi 494038470 163 tfvfgkqeVKTKVHYMMP 180
gi 551074306 156 tfqfgmqtITTKVFIVLP 173
gi 568813117 148 --------RRRRTQMNLI 157
gi 522212935 156 -fvfgnqhVKTRVHMMTP 172
gi 518363629 154 vwdfggtlIETRTVIGVP 171
gi 498182789 160 rqpfepleGETRVQISLP 177
gi 934119074 159 qfqfgqqtISTKVHMMVP 176
gi 521004162 160 kfrfgdqtITTRVNVMVP 177
gi 746991732 156 vhifghqrVETKVYLMLP 173
gi 291348391 158 tfvfgeteVRTGVAMVVP 175
gi 269791287 159 ltlfgsqgVRTRIYHILP 176

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