Conserved Protein Domain Family
DMSOR_beta_like

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cd16371: DMSOR_beta_like 
uncharacterized subfamily of DMSO Reductase beta subunit family
This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.
Statistics
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PSSM-Id: 319893
View PSSM: cd16371
Aligned: 121 rows
Threshold Bit Score: 157.339
Threshold Setting Gi: 288893631
Created: 15-Jan-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Fe-S cluster
Feature 1:Fe-S cluster binding site [ion binding site]
Evidence:
  • Comment:predicted based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #      #### ##   #   #                                                         
gi 484578779   7 AFYVDTTKCINCKTCEIACKDINNAal----------------------------------------------------g 34
gi 780828657   5 GIYFDQTRCTGCYTCVIACKDWYDAdtg---------------------------------------------------p 33
gi 290883310   5 AFYFNQDRCMGCNACTVACKDWNGVepg---------------------------------------------------q 33
gi 361857248   5 AFYFDQSRCYSCQACSLACKDWNNLgig---------------------------------------------------p 33
gi 218763424   4 GFYFDQTRCTGCNACRVACKDWNDVpeg---------------------------------------------------p 32
gi 554691272   4 GFYFDQTRCIGCNACTVSCKDWNQVnpg---------------------------------------------------p 32
gi 816393027   5 GFYIDQTRCIGCYTCVVACKDWHDTkag---------------------------------------------------p 33
gi 290883765   5 GFYFDQTRCVGCKACMLACKNWNDDrrgdyninsdsmnpdtdwyssgtyvvdvndmedvsnylnsagetnyeqnrkyymk 84
gi 554691769   5 GFYFDETRCVGCKACMIACKENNEElrgdinihqynintdytkd-------------------nkvnipsidecskyymk 65
gi 239521228   5 GFWFDQQDCINCHACEIACKVWNEEkrgd------------------------------------------------arl 36
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           # #                                        #  ####    #   ##  ##         #   
gi 484578779  35 qRIRKVRSFEVGeypk------------------------ifvyNISMSCNHCedPQCVKACPAGAYTKRe--DGIVVHN 88
gi 780828657  34 vNLMRVRCLEHGvfph------------------------lfaaYLATPCYHCaqPPCVQACPENAITKRa-aDGIVVVD 88
gi 290883310  34 aSWRRYSNEESGtfpn------------------------vevfNLVLSCNHCanPACTAACPVGAIYKRe-eDGIVIVN 88
gi 361857248  34 eKWMTVYEWEEGsllh------------------------srihVVAFSCGHCenPVCLKACPNHAIFKEt-kYGAVLID 88
gi 218763424  33 eAWVQVKYLEQGetpd------------------------vfvaYMIQTCFHCesPICAEACPAGAITKRp-eDGIVLVD 87
gi 554691272  33 vRWRKQENHEKNngls-------------------------vfeNLTMSCNHCeePACMAACGANAITKTd--KGIVIVD 85
gi 816393027  34 aNWMRIKEIEKGrfpd------------------------lylaFLPSACFHCmePACLKACPVDAITKRe-sDGIVVVD 88
gi 290883765  85 eDWRRVNANERAypy--------------------------alkHISLACNHCtnPACVEACPMGIIYKEe-eYGLVLVN 137
gi 554691769  66 eNWRRVSQTIEGtfpa------------------------lkmtNLSISCNHCinPACIPACPVEAISKDs-eYGIVQSD 120
gi 239521228  37 yPLRELTEGSAGenateknyymkerlrrswyeergnkppdlmryNMNISCNHCskPACVDACPTGRIYKEdtyGIVLANE 116
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                  ####   ### ##                    # #####           #   #    #   
gi 484578779  89 PDLCIG----CRYCTWACPYGAPQFNEe------------vGKVRKCNMCidNVKEGELPACVSACPTRAIEIG 146
gi 780828657  89 QEKCVGaarcPKRCRKACPWGAPQFGPes-----------dARMHKCQMCfeRLAEGQQPICVEACPMFALEVE 151
gi 290883310  89 RDLCQD----IKACAVACPYGAPQFGDddsepvpeaswavaHPMQKCTFCwdRLAEGLKPACVAACPQRALDFG 158
gi 361857248  89 QDKCKG----TRQCAVVCPYGAPKFADda----------pgTKMSKCTMCidRLEQGDLPICVASCPMRALDFG 148
gi 218763424  88 RNACLGkeecGAKCLKACPYDAPQFGPep-----------gAKMGKCVFCtdRLAQGKMPSCVEACYTRALDFG 150
gi 554691272  86 RNKCQQ----LLSCIIACPFAAPHIADnlqepkkgenwivdHPMQKCKFCweRIEDGNAPVCVSACPVRALDYG 155
gi 816393027  89 QELCLGktecGSKCLKVCPWDAPQFGAee-----------nAKMEKCNLCvdRVENRKQTICVEACPVYALDVG 151
gi 290883765 138 NETCIS----CGKCKEACPWDAPQFYApdfsqyq-lddttrPKMTKCTLCldRIQEGLKPACVAACLNRALDAG 206
gi 554691769 121 RSICIS----CGSCEAECPWEAPQYYDknyadya-eedparPRMTKCNLCigRIKEGLKPACVAVCPARALDAG 189
gi 239521228 117 EIPCIS----CGRCQKACPWEAPQFYTilk---------erPVMVKCDLCmeRIGKGLKPACVAACPMRALEAG 177

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