Conserved Protein Domain Family
DMSOR_beta_like

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cd16374: DMSOR_beta_like 
uncharacterized subfamily of DMSO Reductase beta subunit family
This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.
Statistics
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PSSM-Id: 319896
View PSSM: cd16374
Aligned: 26 rows
Threshold Bit Score: 141.643
Threshold Setting Gi: 805338589
Created: 21-Jan-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Fe-S cluster
Feature 1:Fe-S cluster binding site [ion binding site]
Evidence:
  • Comment:predicted based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #      #### ##   #   #                 # #            #  ####    #   ##  ##     
gi 239910434  12 IFINPAKCIGCRHCEIACAVEHsksknlfsaifedplPQPRIHILpmg--ayNVPMNCRHCENAPCMEVCPTGAIFKDeD 89
gi 5458895     5 IFLDYRRCIACKACEVACEMEH---------------GEARIRVFefp-dltSIPFNCRHCERAPCLEVCPTGALYRDcD 68
gi 319752621  10 RIIDLGTCIGCGACEAACDFIHd--------------GHPYIKVYrte-iglEIPVSCMHCAKAPCIDVCPTGAMTRDsD 74
gi 664800832   3 LFINLGRCIACKACEVACEKEH---------------GISFISVYefe--dmAVPLNCRHCEKAPCIEVCPTKAIKRDgD 65
gi 700303772   5 VFIDFRNCIGCRACEIACAREHh--------------GKANITLIets-ellMMSFNCRHCENAPCMLVCPARALYRDeD 69
gi 573024834   6 LHVDYSLCIGCETCQSVCEFIHh--------------GKPHIRIYyte-sglPIPINCRHCEKAPCMNVCPSNAIYKDtD 70
gi 383796196   5 LIMDPKKCIGCRACEVACETLHn--------------GISNITVYtvedslvNVPLTCMHCKDAQCINICPVGAMKRDeD 70
gi 931364115  20 VHIDIDRCIACRACEAACEREHs--------------GISHIFVTpin-dkySIPLSCLHCEKSPCVDVCPTKALEKTsY 84
gi 116666086   4 IYLDPERCIGCRSCEVACEREH---------------GHPRISVGivg-dlaAVPVYCHQCDTSPCTAVCYTGSLRLD-G 66
gi 357210367   3 IYVDLERCIFCRACEVACERVH---------------GTSRISVEavk-draSVPVACHHCEAAPCALVCPSGALTQE-E 65
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1          #         ####   ### ##        # #####           #   #    #             
gi 239910434  90 GAVLVDTSKCIGCKMCAIVCPFGIPEFDtlnGVMFKCDMCPDRraegrpPACVEACKTGALMFGTIDEVVSQVR 163
gi 5458895    69 NAVAFDPLKCIGCLMCAVACPFGVPKLDeanKIMDKCDLCADRraqgklPACVSACPTDALKYGDINEILWKRE 142
gi 319752621  75 GAVYVAASKCIGCMACLYACPFGIPELDrslRVSTKCDLCMDQrrkglePGCSSICPAGAILYGEEAAVFERAK 148
gi 664800832  66 GAVIINEEKCIGCYMCSAVCPYAIPIVDpikELAVKCNLCADRrkegnlPLCASVCPTDALVFGEINEIMEEKR 139
gi 700303772  70 GAVRVKAQDCIGCMFCSVACPFGTPEFVpelKIMAKCDLCSHRreegklPACVTTCPTDALIFASEEEILQIKV 143
gi 573024834  71 GAVIIDPKKCIGCLMCLAVCPFGAPSYEarlKVVTKCDMCADRrrvglePACSEMCPAEAIFFGRPEEVEDEIR 144
gi 383796196  71 GAVYVDSLQCIGCGMCTIACPFGIPMLYselKVAVKCDLCMDRrkaglkPACATVCPADAITYRKIEDVAAQKR 144
gi 931364115  85 SAVIFRKISCIGCRLCTIVCPFGVIQIDe-eGNVLKCDKCIHRlkegkdPACVLTCPTKALIYGKRDQIMTRKR 157
gi 116666086  67 DMVAFDQDLCTRCGLCVVACPFGAIELR---SMIQRCDLCIEKe----tPICVMTCPAEALRLGDVDVVSRSTR 133
gi 357210367  66 AEVGFEAGKCTRCGLCVVACPFGAVDLDp-aSMVQKCDLCPDRe----vPPCVLTCPAEALIFGDRFEATEVLR 134

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