2HL7,2KW0


Conserved Protein Domain Family
CcmH_N

?
cd16378: CcmH_N 
Click on image for an interactive view with Cn3D
N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
Cytochrome c-type biogenesis protein CcmH is a membrane-anchored thiol-oxidoreductase that is essential in the maturation of c-type cytochromes. CcmH consists of an N-terminal catalytic domain with the active site CXXC motif and a C-terminal domain of unknown function which is predicted to contain TPR-like repeats. Other members of this family include NrfF, CycL, and Ccl2.
Statistics
?
PSSM-Id: 319866
View PSSM: cd16378
Aligned: 205 rows
Threshold Bit Score: 55.6126
Threshold Setting Gi: 938507622
Created: 28-Mar-2013
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:putative catalytic site [active site]
Evidence:
  • Comment:The catalytic cysteine residues of the conserved CXXC motif, located in a long loop connecting the first two helices, form a disulfide bond in the oxidized enzyme. Both cysteines are required for cytochrome c maturation during aerobic growth, whereas only the second cysteine is required for cytochrome c maturation during anaerobic growth.
  • Citation:PMID 9914305

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                     #  #                                                  
2HL7_A        16 ERERFRNLTQELRCPkCQNqDIADSNApiAADLRKQIYGQLQQGkSDGEIVDYMVARYGDfVRYKPP 82
gi 126636575  41 LKHQAIAIASGLRCPmSTNqSLQDSQSpiANELKAEIYLQLEQGkTSDEIVDFMVVRYGErIRYMPS 107
gi 917734029  25 IARLSIDISKELRCPmATNqNLFESETaiASELKAQIYLMLQQGkSREQILEFMVERYGEqIRYQPS 91
gi 940690070  53 KRALGFEIAQELRCPiSDNrSLFDSQTqiANELKGHIFQKLDEGqSKQQIIDFMVARFGErIRYTPS 119
gi 654653224  27 LHRAVNAIAADLRCPsSVNlNVLESEApiAYELKGQIAEQLNQGkSRDQIIDFLVQRYGEqIHYQPA 93
gi 737404330  25 LSQRAERLASTLRCPaSVNqTLADSEAaiAFELKGLIAQQLRAGhQEEQIVQYLVERYGEqIRYQPG 91
gi 81446029   42 YQQQAIAISKELRCPmATNqTLFESQApiAHELKGQIFSLLEQGyKRDEVLDFMVQRYGEkIRYQPE 108
gi 491577166  38 LQKEAVSISKVLRCPvSPNlTLYDSESaiANELKGVIYEKLRAGeTREQIFDFMVARYGEqIRYEPD 104
gi 378597589  49 LQEEAIRISKLLRCPaSPNlTLYESEAaiASELKGRIFMMLREGkSRDEIIRWMIERYGEqISYMPD 115
gi 503110433  25 QRHQYEAIAAELRCPaSVNlTVLESQApiAFELKARIAERLLEGaSKETVMTELEQRYGPqIRYRPA 91

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap