2HL7,2KW0


Conserved Protein Domain Family
CcmH_N
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cd16378: CcmH_N 
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N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
Cytochrome c-type biogenesis protein CcmH is a membrane-anchored thiol-oxidoreductase that is essential in the maturation of c-type cytochromes. CcmH consists of an N-terminal catalytic domain with the active site CXXC motif and a C-terminal domain of unknown function which is predicted to contain TPR-like repeats. Other members of this family include NrfF, CycL, and Ccl2.
Links
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Statistics
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PSSM-Id: 319866
Aligned: 205 rows
Threshold Bit Score: 55.6126
Created: 28-Mar-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:putative catalytic site [active site]
Evidence:
  • Comment:The catalytic cysteine residues of the conserved CXXC motif, located in a long loop connecting the first two helices, form a disulfide bond in the oxidized enzyme. Both cysteines are required for cytochrome c maturation during aerobic growth, whereas only the second cysteine is required for cytochrome c maturation during anaerobic growth.
  • Citation:PMID 9914305
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #  #                                                  
2HL7_A        16 ERERFRNLTQELRCPkCQNqDIADSNApiAADLRKQIYGQLQQGkSDGEIVDYMVARYGDfVRYKPP 82  Pseudomonas aeruginosa
ABO22218      41 LKHQAIAIASGLRCPmSTNqSLQDSQSpiANELKAEIYLQLEQGkTSDEIVDFMVVRYGErIRYMPS 107 Shewanella loihica PV-4
WP_052248294  25 IARLSIDISKELRCPmATNqNLFESETaiASELKAQIYLMLQQGkSREQILEFMVERYGEqIRYQPS 91  Shewanella sp. ECSMB14102
WP_055023501  53 KRALGFEIAQELRCPiSDNrSLFDSQTqiANELKGHIFQKLDEGqSKQQIIDFMVARFGErIRYTPS 119 Shewanella sp. P1-14-1
WP_028114207  27 LHRAVNAIAADLRCPsSVNlNVLESEApiAYELKGQIAEQLNQGkSRDQIIDFLVQRYGEqIHYQPA 93  Ferrimonas kyonanensis
WP_035385482  25 LSQRAERLASTLRCPaSVNqTLADSEAaiAFELKGLIAQQLRAGhQEEQIVQYLVERYGEqIRYQPG 91  Ferrimonas futtsuensis
Q8CVD6        42 YQQQAIAISKELRCPmATNqTLFESQApiAHELKGQIFSLLEQGyKRDEVLDFMVQRYGEkIRYQPE 108 Shewanella oneidensis
WP_005434741  38 LQKEAVSISKVLRCPvSPNlTLYDSESaiANELKGVIYEKLRAGeTREQIFDFMVARYGEqIRYEPD 104 Sutterella wadsworthensis
EHY30862      49 LQEEAIRISKLLRCPaSPNlTLYESEAaiASELKGRIFMMLREGkSRDEIIRWMIERYGEqISYMPD 115 Sutterella parvirubra YIT 11816
WP_013345175  25 QRHQYEAIAAELRCPaSVNlTVLESQApiAFELKARIAERLLEGaSKETVMTELEQRYGPqIRYRPA 91  Ferrimonas balearica

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