2CC3,4NHF


Conserved Protein Domain Family
VirB8_like

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cd16384: VirB8_like 
Click on image for an interactive view with Cn3D
virulence protein VirB8
This family contains bacterial virulence protein VirB8 and similar proteins which consist of cytoplasmic, transmembrane, and periplasmic regions. VirB8 is an essential assembly factor of type IV secretion system (T4SS) channel proteins that are highly diverse in function relative to other bacterial secretion systems. T4SS proteins are important virulence factors for many Gram-negative pathogens, such as Agrobacterium, Brucella, Legionella, and Helicobacter. This family also includes the conjugal transfer protein family TrbF, a family of proteins known to be involved in conjugal transfer. The TrbF protein is thought to compose part of the pilus required for transfer. This domain has a similar fold to the nuclear transport factor-2 (NTF2) protein.
Statistics
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PSSM-Id: 319760
View PSSM: cd16384
Aligned: 3 rows
Threshold Bit Score: 186.768
Threshold Setting Gi: 325533262
Created: 29-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
dimerization
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: dimerization motif [polypeptide binding site], 4 residue positions
Conserved feature residue pattern:N P X GClick to see conserved feature residue pattern help
Evidence:
  • Comment:NPXG motif of each monomer in the dimer is important for dimerization
  • Structure:2CC3: Agrobacterium tumefaciens VirB8 structure protein-protein interaction sites; contacts 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2CC3_A         8 EAVVNASLWEYVRLRE-SYDa----dTAQYAYDLVSNfs-aPMVRQNYQQffnypnptspqvilgkhgRLEVEHiASNDv 81
4NHF_A        42 EVVDRYWLNQYVLNRE-NYDy----dTIQLNYDTTALls-aASVQQEYYKiydgenar--dkvlsnkaRITVKVrSIQLn 113
gi 325533262 118 RVVHASVAAFINDLRMvTPDialqrrAIFRAYAMLSNndpaTAKANEWFNsseassp----fkraetqTVNVEIiSVIPq 193
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                                                         ####          
2CC3_A        82 tpgvQQIRYKRTLivdg--kmpMASTWTATVRYEkvtslp---grlrltNPGGLVVTSYQTSE 139
4NHF_A       114 glgqATVRFTTQQldssgattgPKQHQIATIGYTyvgapmk--ssdrllNPLGFQITSYRSDP 174
gi 325533262 194 spetWQVDWLEKVydrqghltePPFKMRALLRVYnkpttqstteeqirnNPLGIYIQDFSWSK 256

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