3WZ4,3WZ3,3WZ5,5CNL


Conserved Protein Domain Family
IcmL

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cd16385: IcmL 
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inner membrane protein IcmL/DotI
This family contains the periplasmic domain of the inner membrane protein DotI of the Dot/Icm (defect in organelle trafficking/intracellular multiplication) type IVB secretion system, including its ortholog in the conjugation system of plasmid R64, TraM, and similar proteins. These domains share striking structural similarity to the type IV secretion system (T4ASS) component VirB8 suggesting DotI/TraM to be its functional counterpart. DotI is essential for intracellular growth of Legionella pneumophila (causing agent of Legionnaires' disease) within mammalian and protozoan cells; it translocates numerous effector proteins into its eukaryotic host.
Statistics
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PSSM-Id: 319861
View PSSM: cd16385
Aligned: 158 rows
Threshold Bit Score: 72.6772
Threshold Setting Gi: 518047635
Created: 29-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3WZ4_A         6 SDSAVLQWANQAAIAAF--TYNFv--NYRDELQASSGFF----TAEGWDQFLGALe-qSNNLDAVKakKLVVSAVAt-rA 75
gi 81370162  301 TPSDFGNKGRKLYPNWLs-QIGLh--SSKLQLNSLITRInplpLWRVFSQYQQSIrdkSDNIEAISkqKPILSAQIe-gE 376
gi 347589723 114 NQDELAKWLDRAVAETM--SFSPa--SYPDHIKHLATGF----TPEGLAQFQAWVq-nANLIQAMEtgHLQMNGFVq-eA 183
gi 504881508  83 NYTYAGDIAEDYAEDLL--SFHFl--KIDKQIQSRNSYFf---QGYFAPLYMEPLi-eSNSINKIKnqKLIVTATTv-rK 153
gi 652969400 312 GQKFYPNWLKQIGLHSS--GLSLn--SLISQINRLPLWR----TFSQYQQSIREP---SDNMEAIKnqKPILSAQIe-gE 379
gi 797200766  82 TDRQAMHWARDKASELL--SLSFn--SYADQIRRRKQYF----VGDGWMKYQLSLi-eNKVTETLReeGLIITAINq-dT 151
gi 919118292 296 TATLDSLFSTNKIKKNSpdLFDFksdILAEQLQKVVPYS----MDQCLNTLAVALd-kIKNAKVIQtkELTLKSQKn-sE 369
gi 919118292  57 EHDVVINWAKYAVIESF--NFNPs--SIDMQMSRLRSCY----TNKGWNAFINAQq-eSGNLKELKthSLYMSSQLd-gR 126
gi 966502433  76 DNALIVSWAEYAVLHSF--KFDLl--SFDAQLNNLKKCY----TKNGWTSYINALt-dSGNINSIKtqKLMVSSMLd-gK 145
gi 966503283 334 SALHNLDTIKEQSKKQFl-DIKSd--ILATKLPKLLTYF----KEKGTIGFNSALh-nLDKTKAIK--NQNPNSQHrniE 403
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
3WZ4_A        76 PIILqkgvlngrYSWRVQXPILVTYQsa---------seFTQQNNVVTXLITRvstl-----nsprGIGISQFVVGP 138
gi 81370162  377 PQFIev----keNQWDIKLPIKVVYQkd---------neRITQRLDVNLALDQkminn---ltvktKSVDSNKVLQS 437
gi 347589723 184 PFLLnegvvngrYRWLFEIPVMISFFdkdvkfmksstqiKETRRLLVRLQIGRvasg------gleNGVLIETWEVY 254
gi 504881508 154 PRLQgvlldkgyRTFIFNIPIIQTMYgps--------gdPETKSLMLHMRLRQvvrt------eniNGLVISDLGIR 216
gi 652969400 380 PQFIev----keNQWGIKLPIKVVYQkd---------keRITEHLDVHLALNQkmvnnlvvknksiDSSGVLQSLTS 443
gi 797200766 152 PRLLqsyslngnKNWRIEMPILQTIQgas--------dtPKTVKKIVSITVEQtrrd------eaiEGLKIRVFGVI 214
gi 919118292 370 PRLVet----qnNQWDMTLPVQIVYQse---------gdNITKPLNVHLVIERka----------gGGLEITQMKTT 423
gi 919118292 127 PELIea----seTQWKLVVPIKVIYKnd---------qeTAVHFLSIYLTIGWrs----------aFNLGITQMIAI 180
gi 966502433 146 VQLIda----qeTQWKMNVPIKVFYKnd---------keEITHFLNVYLIISWrn----------aFKLGIVQIVAT 199
gi 966503283 404 SQLIen----knNQWNVTLPMQVIYQnd---------knQITQLVNVNLTIGRka----------dGELAILQMNAI 457
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