3UB1


Conserved Protein Domain Family
TcpC_N

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cd16386: TcpC_N 
Click on image for an interactive view with Cn3D
N-terminal domain of conjugative transposon protein TcpC
This family contains the N-terminal domain of conjugation protein TcpC and similar proteins. TcpC is required for efficient conjugative transfer, localizing to the cell membrane independently of other conjugation proteins, where membrane localization is important for its function, oligomerization and interaction with the conjugation proteins TcpA, TcpH, and TcpG. N-terminal region (sometimes referred to as central domain) of TcpC is required for efficient conjugation, oligomerization and protein-protein interactions. TcpC has low level sequence identity to proteins encoded by the conjugative transposon Tn916, which is responsible for a large proportion of the tetracycline resistance in different pathogens.
Statistics
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PSSM-Id: 319860
View PSSM: cd16386
Aligned: 182 rows
Threshold Bit Score: 51.9213
Threshold Setting Gi: 374977725
Created: 29-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
trimer
Conserved site includes 49 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Comment:Each protein molecule contains a C-terminal domain and a Center domain, separated by a linker; 3 together make a non-covalent trimer related by a molecular threefold axis, generating a triangular-based pyramid in which the Central domains form the core of the pyramid and the C-terminal domains the apexes
  • Structure:3UB1: Clostridium perfringens conjugation protein TcpC homotrimer; contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            # ### ##   #  ##                    ###         #   #  #         #    ##    
3UB1_A         2 EKQSSLETQAFSFAEEFAWDYFSRYps----dtQDFVRRITKYt------tEQLANEXNNg--------TYSDVIYTs-- 61
gi 701522805  85 EVGFANSPAGEDYSRQFIDTYINVPdde--kqrEERFKALQSFl------aEGLEVGQLE---------NLSEFKGKrvl 147
gi 295112468  75 VREELDYSALSFYVQNFVKEYVNVDskandkdkKARTERLQKYlsvdsktvDETEENKQD---------FKRKLLTAs-- 143
gi 924111523  76 ENSLISQEATNSFAQSFAWTYLNIEkde--narKEREKKLVKLla----tnLPVQELGGTge------iSAKRTATSvkp 143
gi 654950963  76 SNSLIQQEATVSFAQQFASLYLNIDsdq--narTDREKRLVKMl------aSNLAVQELEgt------gNINAKRTVts- 140
gi 502726293  86 TEDILESPLLNVYTRDFVSEYINISade--eerEQRLDELERYf------vSGFDVSSLE---------DTSEFAGSrnv 148
gi 81436447   75 VREEFDYSALSFYVENFAKEYLNYNskasdeakKARIDRLSKYlsl---dvKDVDETENLqg-----nvLRTFKNTS--- 143
gi 514896240  75 NQESYDYAALSFYATNFVKEYMGYDasadedkkKERLERLSDYlsm---dvETIDETGKTvl-----dfSRKFKEAA--- 143
gi 498446502  75 TESTYDIVALSFYATSFAKEYLNMDttadenkkNERLERLSNYlsi---dvEAVDESTNQql-----eiVRQFKEAS--- 143
gi 430564175  75 QKEVFDYSALSFYATSFAEEYLNYDasaneeekKERLDRLEKY--------LSVDVDAVDetsksqkefIRRFKSAA--- 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ##### #       ###   # #                                       #### # ###    
3UB1_A        62 ----AFYFEKYse----nQVNVSVKARVRvytpkagqeqt---------------pqdqlqydtnLVDYYLEVPIVFDKd 118
gi 701522805 148 ksasLYDVKDVseaaasyVYRIEYELFKIvekkeqvevkkknkngk--vevvkeekttrkdeslgKKQQMIVVRLGTDGn 225
gi 295112468 144 ----LARIEDTa-----dCKLVYVNVSYEvmvg----------------------------kkksTITQVMVLPIQTKDn 186
gi 924111523 144 yklkVLNEKQAl-----vTLLVSYKVEKEnve-------------------------------pqNITQLLNFSVGTDGt 187
gi 654950963 141 --ikPYKVKVLnk----sQALVTLLVSYKierpn---------------------------vepqNITQLLNLMIGTDDt 187
gi 502726293 149 tsirLLDIKRAgq----nEANVHYLVAYDiketeevekevtkeegegedkkevtetvmeeeervtSHDIEMVIPLTTDGe 224
gi 81436447  144 ----LSRIEKMe-----dCYLVYLNVNYElekd----------------------------kkteNVTQNMVLPIQVKDn 186
gi 514896240 144 ----LVQVKEEs-----dCLLVYVNVTYDvtme----------------------------dkteTITQDMVLPIQTKNq 186
gi 498446502 144 ----VTKVIEEeec-llvYVYTTYEVKQKdk--------------------------------veTISKEMVLPIQAKDq 186
gi 430564175 144 ----VVQIKEEs-----eCLLVSLNVIYEteke----------------------------eekkTLTQEMVLPIQTKNq 186
                        170
                 ....*....|....*
Feature 1         ### ######### 
3UB1_A       119 xNXAVDALPVXTAPP 133
gi 701522805 226 -SFNVMEQPYYQALP 239
gi 295112468 187 -LFSVVSRPYFVATS 200
gi 924111523 188 -NFNVIEQPYFLPAP 201
gi 654950963 188 -NFSVIEQPYLLSAP 201
gi 502726293 225 -GFAITGYPSLANSH 238
gi 81436447  187 -LFSIVGRPYFVASS 200
gi 514896240 187 -LFSIVSRPYFLAAA 200
gi 498446502 187 -LFSIVSRPYFLATT 200
gi 430564175 187 -LFSIVGRPYFLATT 200

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