1VZ0,1XW3,1VK1,4RSF,2HWJ,4O7K


Conserved Protein Domain Family
ParB_N_Srx

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cd16387: ParB_N_Srx 
Click on image for an interactive view with Cn3D
ParB N-terminal domain and sulfiredoxin protein-related families
The ParB N-terminal domain/Sulfiredoxin (Srx) superfamily contains proteins with diverse activities. Many of the families are involved in segregation and competition between plasmids and chromosomes. Several families share similar activities with the N-terminal domain of ParB (Spo0J in Bacillus subtilis), a DNA-binding component of the prokaryotic parABS partitioning system. Also within this superfamily is sulfiredoxin (Srx; reactivator of oxidatively inactivated 2-cys peroxiredoxins), RepB N-terminal domain (plasmid segregation replication protein B like protein), nucleoid occlusion protein, KorB N-terminal domain partition protein of low copy number plasmid RK2, irbB (immunoglobulin-binding regulator that activates eib genes), N-terminal domain of sopB protein (promotes proper partitioning of F1 plasmid), fertility inhibition factors OSA and FiwA,DNA sulfur modification protein DndB, and a ParB-like toxin domain. Other activities includes a StrR (regulator in the streptomycin biosynthetic gene cluster), and a family containing a Pyrococcus furiosus nuclease and putative transcriptional regulators sbnI (Staphylococcus aureus siderophore biosynthetic gene cluster ). Nuclease activity has also been reported in Arabidopsis Srx.
Statistics
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PSSM-Id: 319246
View PSSM: cd16387
Aligned: 323 rows
Threshold Bit Score: 27.9375
Threshold Setting Gi: 114794599
Created: 1-Dec-2014
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative active
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Putative active site residues by comparison to ParB N-terminal domain-containing superfamily proteins such as Osa and Srx

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         # #                                                                            
1VZ0_G        43 AEESLk--ELADSIREkg-llQPLLVRpq--------------------------------------------------- 68
gi 612172826  34 RNQKVf-sGLVESIATvg-lkRPVTVTengad------------------------------------------------ 63
1XW3_A        31 DPAKVq--SLVDTIREdpdsvPPIDVLwikga------------------------------------------------ 60
gi 56708009   66 KNIDSl--ADSIKENGvi-qpIIVTAKka--------------------------------------------------- 91
gi 254947522  51 NEQSLn--TIEVAQRKldishASSIAKyilkgllaaisnsprlngsssfariskamgeqpyiaipp-----lvaslrntg 123
gi 978492698  60 NDPGRd--GAQVAQRKldpahANKLAIyvlkglvaaaikrreiekkpipeeylgvqavlgkapylsl---qplvvnirec 134
gi 966689134  52 FEADIg-sAFTRSQRPvngkrAKGVTSyilnnstnyvipsltatiedftpskdivgsvi-------------------yd 111
gi 940007436  64 SDVANdrdTGPVAQRQldeghAKKLAIymvkglisaakmrriatnkpvpetfddlvrvlgeqpyfslqplvcnirnvppg 143
gi 980267831  53 SRADLg--NEEIAQRNldpkhAQKLAVyllkglahalatkyrregaelpaaldriqrtlgkqpyl--------aiqpita 122
gi 653177302  46 SERGId--SYLGIQRDldpkrVREIAQyvkgtdatfptavvlavpekcvtiespcs------------------------ 99
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
Feature 1                                           #  ##                 
1VZ0_G        69 ----------------------------gdGYELVAGERRYRAALMAGlqEVPAVVK 97
gi 612172826  64 --------------------------gegpFYDLVCGQGRMEAFKALGetRIPAMVV 94
1XW3_A        61 --------------------------qggdYFYSFGGCHRYAAYQQLQreTIPAKLV 91
gi 56708009   92 ----------------------------ngIHYIIAGERRYLASKQAGltTIPCIVR 120
gi 254947522 124 fggsnlqvlplktigseevacfkiflsqsdTLWIVDGQHRRKAIELVSd-FIRHVLT 179
gi 978492698 135 npegqnirgirmvtsdnetaafkvfisqrhVLWVVDGQHRRKAMEMVFe-FLDTVRN 190
gi 966689134 112 dadfttshiknedlensfgdavflsvpetsRWWFIDGQHRATGIQGLKs-ALGAMGM 167
gi 940007436 144 gngaggirgfrlettagetaafkvflserhTLWVVDGQHRRHAAAMAIt-FLDQVRQ 199
gi 980267831 123 nirtcdfggkglrfeqaggglvnvylankdVLWVVDGQHRRFAMDMLFd-YLRTLTT 178
gi 653177302 100 --addrfvrmtlsnypqgeddpeeavyyrhIARVIDGQHRIRGLEGYAg-TDFDVNV 153

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