4O7K


Conserved Protein Domain Family
FIN

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cd16389: FIN 
Click on image for an interactive view with Cn3D
fertility inhibition factors, including OSA and FiwA, related to the ParB/Srx superfamily
Osa and FiwA are fertility inhibition factors (FIN), which are employed by plasmids to block import of rival plasmids. Osa (oncogenic suppressive activity) of IncW group plasmid pSa gene inhibits the oncogenic properties of Agrobacterium tumefaciens. Osa is structurally similar to the ParB N-terminal domain/Srx superfamily of proteins: ParB acts in the bacterial and plasmid parABS partitioning systems. Osa has been shown to have ATPase and DNAse activities, an can block T-DNA transfer into plants. FiwA is encoded by plasmid RP1 and blocks the transfer of plasmid R388. The gene product of Haemophilus influenzae p1056.10c also blocks T-DNA transfer.
Statistics
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PSSM-Id: 319248
View PSSM: cd16389
Aligned: 19 rows
Threshold Bit Score: 157.429
Threshold Setting Gi: 516030779
Created: 17-Dec-2014
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 5 residue positions
Conserved feature residue pattern:D K [DN] T RClick to see conserved feature residue pattern help
Evidence:
  • Comment:Predicted active site residues based on analysis of Osa

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                    # #                                 
4O7K_A        58 TASNAAQSDFIVYVNGLAFYRAWLALGVEdsqa--cplkQDMPKDRKYPSSAAHFAVGidSPVPLADVSptmi------- 128
gi 672592196  43 YHSSSDEVKKIVFVQDTKFLAMWKNAPYLqdihlssgseREWRNDNKFHHAERAFRIGrtNPVPLADVScteyikstpiy 122
gi 646772566  33 RTNYLNEERAVVEVDTGRLFALWRAEPNGlhaaqahgheRTWRRDDKFQHAEEGFQGGkdNPVPLADIScqigrrrhpii 112
gi 754973878  37 RTGYENDRRAVVEVDADRFLDLWRRDPYEahadvsrgnpTTWVRDRKFSYAEEGFAGGesNPVPLADVDctthikqrply 116
gi 51507269   45 IENMANQENMIVIVDAQKFLPLWQRSPYEvdkntcagdeSTWRKDYKFHHAENGFANSidSPVPLADVNvhik------- 117
gi 342795240  47 LQPSDEDCYFVIFVDRYRFESVWFKGGSGvapelargneKAWRKDYKFHHAERGFSHGieNPVPLAVMQany-------- 118
gi 764605281  42 IFHTPNKEMRIVFVQDHKFLSLWQNMQFPqepqlsfgneSAWRNDRKFLWAEKALSQGreQPVNLAEVTcteylkripiy 121
gi 640857884  50 QEISDTSENYIVIADRDKLLSAWRNTPNSivpelsrgdeAAWRRDRKFHEAERCFSIGagNPVPLATPTcrfile----- 124
gi 516030779  46 RNNGLNASRFIVEVDANRLLTLWKRDAFAppsv---hgrQRWSEDYKYDRAEEGFSRGqqNPVGLAKVYvrdrpvyaelp 122
gi 654911552  33 SASPGDASVAVVEVDADRLLEQWRRTGGKperca-hasqALWPSDEKFAAAEIGFMEGqfDPVPLALMTcrae------- 104
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                                         #  ##                                    
4O7K_A       129 ------------------------lghFAVCFTDGMTRSMWLLAHEVAVFPVLSRDEasAVMLAEHVGVAAPIQ 178
gi 672592196 123 eksf---------lwfkklvgyseeqvTWCSFINGITRTIWLLANGVKQFPVYVYNEknAILLAKHAGISPSSF 187
gi 646772566 113 qkkw---------llfertvgwnehrfPYVAFTNGVTRTIWLAANGAKYFPVECHVRe-ADRLQELAGLPGGGW 176
gi 754973878 117 rsrl---------lvlrklvgyerediPHVSFSDGITRTIWLLTHGARVFPVMCSVSe-APLLKQLAGLPGGSF 180
gi 51507269  118 ------------------------dgeISCSLNDGMTRTLWLLANGVKEFPILIRNHkeKAKILSKYASPLSSL 167
gi 342795240 119 -------------------------dyPRVGFTDGITRTVWLLANGAKNFPLFAFNKktAEYLYKYIGIKGSKV 167
gi 764605281 122 ekrf---------cwfskfvgykhsnqVECSFIDGITRTIWLLANGVRQFPVYVYNEqeAVLLAKYAGIHQNAY 186
gi 640857884 125 ----------------------rglpvPALDFVDGITRTIWLLANGADRLPVHAYNHhdALLLQRGKGIGLHRQ 176
gi 516030779 123 pvprfsiralatrrkpgrpaaqpsvmeTVATLNDGCTRTIWLLANGVATFPVECDGQasAERLQHLAGVGSPIL 196
gi 654911552 105 -----------------------nggpVQLSIADGVTRTIWLLTAGATIFPVSCPIDd-ACALQACAGAAGSRV 154

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