2HWJ,2HWJ


Conserved Protein Domain Family
ParB_N_Srx_like

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cd16390: ParB_N_Srx_like 
Click on image for an interactive view with Cn3D
uncharacterized family distantly related to the N-terminal domain of the ParB/Srx superfamily
Uncharacterized proteins distantly related to the N-terminal domain of the ParB superfamily, primarily involved in bacterial and plasmid parABS-related partitioning systems. A small minority of proteins in this family include a C-terminal inorganic pyrophosphatase domain. Also within the ParB superfamily is sulfiredoxin (Srx), which is a reactivator of oxidatively inactivated 2-cys peroxiredoxins. Other families includes a putative regulator in the biosynthetic gene cluster and a family containing a Pyrococcus furiosus nuclease and putative transcriptional regulators SbnI (Staphylococcus aureus siderophore biosynthetic gene cluster ) and EdeB (Brevibacillus brevis antimicrobial peptide edeine biosynthetic cluster). Nuclease activity has also been reported in Arabidopsis Srx.
Statistics
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PSSM-Id: 319249
View PSSM: cd16390
Aligned: 110 rows
Threshold Bit Score: 69.5149
Threshold Setting Gi: 651595575
Created: 29-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
putative activehomodimer
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Putative active site residues by comparison to ParB N-terminal domain-containing superfamily proteins such as Osa and Srx

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         # #                                                            
2HWJ_E         9 LSRIAIDKLRPTQiaVGFREVELKRKEWREtrkk---------------------------------------------- 42
gi 407211069  23 EVTLTIAKLHPTQavLAYDQVTKKIDKYQHqqka---------------------------------------------- 56
gi 301167564  39 LEFISLSNIHPTQafVGHDQIPLKIEKIQKklkkk--------------------------------------------- 73
gi 577767309  35 RYDVPIQSIHPTQadLGKVQMAYKLTTYINengqltedyfadfnddngykkgkylspdgteklqdkakyktadlrdtlqa 114
gi 682106679  58 IIQIKLSELHPTQiaVGKLQIAGDLADYAQdykrlfnelckvqgagklae--------------mnasstpkdpssyrck 123
gi 116055754  76 RWSDVRASVRPTQvaLGWDWTFYKLSNFKDles----------------------------------------------- 108
gi 577775322  35 VYDVPISSLHPTQagIGKIQISYKLTEYLAndaaltasffedfnedngyikgnyltadtqtpkqdknllktvnmreelga 114
gi 632075825  34 EYNVPISTIHPIQaaVGKAQIASKISTYVEngaltknyyndfnddngynnglysln---gvsqtdkttyktnsiqsvipd 110
gi 485641809 103 AWSALRTKVHPTQ--VSVGYVWALKHKVEKmysee--------------------------------------------- 135
gi 335879954  28 VLEVRLADLKPTQavIAHDQVNYKLASYRNdhkklvedfcemsgwgkkvelk-----------aepsllqsdsyqclgke 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                # ##                                                    
2HWJ_E        43 dgddFLGNHIVPVVAGpkDRAYLIDHHHLVLALSKEGVe------HVLTSEVAKFShl------gKDEFWSVXdh--rNL 108
gi 407211069  57 fnkdLNELPRKTVVLGpaGQYYLTDGHHTFSAMREFSPlra--eqPVTVRVTADKSdl------sQTEFWQWLva--nDQ 126
gi 301167564  74 kldsYLKEKWSPAIIGpdEKYWILDRHHLSYALLKSDIadk--ykGLYIRVLHDWSsy------sWNHFYNSMkr--eNL 143
gi 577767309 115 vvdpDVSTPAVTVVIGpdQQYYAIDGHHGANSYLLTKAitgsgsdKVNITVVGDYSdl------sGAAFWKKMaannqYY 188
gi 682106679 124 laigTKKADMNTVDIGptGKLYLTDGHHAFNSFWDVPGggg--dvALSVLVGQNVSrdsngkaltQAQFEQKMte--lKH 199
gi 116055754 109 -attYMARKPVPYVKYr-GLRYVVDHHHTLAALNLTGWd-----vDVYMEEIFEYDdd-----ldDATFWGIMeg--kGW 174
gi 577775322 115 lvnpALGSLSVQVVIGphKEYYAIDGHHGSNTNQLIKEmtglgydKINVAVIADYSdl------dEKTFWQTMlaqkyMY 188
gi 632075825 111 aqltNDSTAKVPVIKGpgGTLYATDGHHGSTTYEFIKQqynlgfdTINVEVIADYSsl------sMADFYKKLiannqVL 184
gi 485641809 136 saqeRMDGKHIPCIKRg-SELYFSDGHHTLSALDSSGFwhlaardAVTIVVLCDLTal------sVADFWATMge--kGF 206
gi 335879954  97 kgkkQKKSAMNTVVLGpdQQLYLTDGHHGFSALYDYVGae----lKVSVLVTDVFDkaqh-qsanNHDFLRQLva--qGL 169
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                                      
2HWJ_E       109 IYPFDAQGL-------RRQSGDIPKNIHDl-------eDDPFRSLAGALRXAGgyakv----iipfSEFGWADFLRRR 168
gi 407211069 127 VWLRDGRGQ-------LVEIDDMPRQVGRef-----maDDPLRGAMYWLRDRYlrkpe---kaipfVEFYWAQYVREH 189
gi 301167564 144 FYLKNCKFE-------EISPEEIPTQINTl-------gNNPYRSLAYFAREKGcfnkv----dipyLEFMWGEFFYRN 203
gi 577767309 189 PKAFNLQTHry----qTIDPERLPKQMGSeq-----fiNDPFRSLNYFMRKSVidkda---isvpfAEFYWGEFLTET 254
gi 682106679 200 FLPIDAEGK-------SITFSQLPNTLGIsg-----fqDDPYRSMLYYLRGISydksdk-nlnpetGKPYPAVPFLEF 264
gi 116055754 175 SFCWDSNYQ-------RLSYADIPTSFELqa-----frNDIFRSLGGFCRKDKllkrgkmledklfFEFQWGYFFWLH 240
gi 577775322 189 PKAYNVATHqy----eTISGLKLPKQMNNql-----fvNDPFRGLNYFWRSTAinkdt---isvpfAEFYWGEFMSRT 254
gi 632075825 185 PMAFNVKTGey----qSFSLDRLPTHMYAne-----fvNDPFRSLAYFWRKSAidkdn---vtanfAEFYLGMFLTST 250
gi 485641809 207 AYLYGRPSGpwtslpePLAFSALPSLVVFnnheppsftDDPWRALSGASRKISnqksck--aaasnTKYCMRAYDRVC 282
gi 335879954 170 SWPKDANGK-------ALPAQQWPKQLGRaa-----lhNDPYRGAAYFLQGGVwkkpk---palpfVEFYWADYLRQQ 232

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