Conserved Protein Domain Family
IbrB_like

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cd16397: IbrB_like 
immunoglobulin-binding regulator IbrB activates eib genes
IbrB (along with IbrA) activates immunoglobulin-binding eib genes in Escherichia coli. IbrB is related to the ParB N-terminal domain family, which includes DNA-binding proteins involved in chromosomal/plasmid segregation and transcriptional regulation, consistent with a possible mechanism for IbrB in DNA binding-related regulation of eib expression. The ParB like family is a diverse domain superfamily with structural and sequence similarity to ParB of bacterial chromosomes/plasmid parABS partitioning system and Sulfiredoxin (Srx), which is a reactivator of oxidatively inactivated 2-cys peroxiredoxins. Other families includes proteins related to StrR, a putative regulator in the biosynthetic gene cluster and a family containing a Pyrococcus furiosus nuclease and putative transcriptional regulators SbnI (Staphylococcus aureus siderophore biosynthetic gene cluster ) and EdeB (Brevibacillus brevis antimicrobial peptide edeine biosynthetic cluster). Nuclease activity has also been reported in arabidopsis Srx.
Statistics
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PSSM-Id: 319255
View PSSM: cd16397
Aligned: 39 rows
Threshold Bit Score: 137.704
Threshold Setting Gi: 566001934
Created: 14-May-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21427218   50 PVDCVLWVKadEIVANDYNPNvMAPSEKKLLKQSLEKDGFTQPIVVSee---tsHYLVVDGFHRQLLGRRTVtg-krLKG 125
gi 984859530  13 PLNHIQWVPaeDLDANAWNPNrVHKPELRLLEHSLLTTGWIQPILANp------DGLIIDGFHRWRLSQDSKavrarWNG 86
gi 566001934   7 PIANIQWVEvsRLQANDYNPNvVVTPEFKLLKFSLLKQGWIQPILACpvpgsdtALEIIDGFHRATLAKTDKevsemAEG 86
gi 167669030   9 PLSSLQWVDrdALKPNDYNPNkVNRENLKLLVQSILTNGWTLPIVVRp------DYTIIDGFHRWTVAGEEPlh-tkLQG 81
gi 589854297   7 PISKITWLKreELTPNGYNPNkVAPPELKLLKISILEDGWTQPIVINq------NKEIVDGFHRWTVSEDKDvs-alTDG 79
gi 936666261  34 PACHVEMIPldEIEANQYNPNkMAPPESKLLKTSMEKNGVTMPILVNrlnisakKYVVIDGFHRYQLLLNHPel-qaLKG 112
gi 219548355  49 PACQLQLIPleCIDANHYNPNkMAPPESHLLQHSIKKNGFTMPIILNrvk-greRYTLVDGFHRFSLLNTSPdl-qaLPG 126
gi 823485371  11 PICQLRLLPihEIEANQYNPNkMASPENALLKRSIEISGLTMPLLVTkki-sgsKYVLVDGFHRYSLLLNHPel-qsIPG 88
gi 405582619  32 PVLNAVLVHksMILPNDYNPNhVAKDKMELLKTSIVENGFAFGIVAIfdn-eidKFVIIDGYHRDVITGKKWl----DLT 106
gi 524688049   6 PCLDVRMVDreELQANDYNPNtVPRDKMLLLKQSILDNGFCFPIVTIwse-edeKYIIVDGFHRFTICQPEWl----NIK 80
                         90       100
                 ....*....|....*....|....*
gi 21427218  126 WLPVTCINPdrkgqtsRIAATIRHN 150
gi 984859530  87 RVPVAVLDVdr---ptAMLMTIRIN 108
gi 566001934  87 KVPVSILSLdv---aeRKMLTIRIN 108
gi 167669030  82 KVPVVVVHHeda--seDIYGTVTHN 104
gi 589854297  80 YVPTVMTEPsng--ehQMMSTIRHN 102
gi 936666261 113 YIPAVVLNLre---ekCMSASVRHN 134
gi 219548355 127 YIPALILDLpe---ekCISTSVRHN 148
gi 823485371  89 YVPVVILDLpe---eeCIATSVRHN 110
gi 405582619 107 YKPLVILDHsm---ekRLAATVQFN 128
gi 524688049  81 KVPIVVLKHdl---sqRMTATVQFN 102
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