Conserved Protein Domain Family
DGQHR_domain

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cd16413: DGQHR_domain 
DGQHR motif containing domain
Uncharacterized diverse domain family with conserved DGQHR motif, in addition to QR and FXXXN motifs. Some proteins have been identified as parts of DNA phosphorothioation systems. Related to dndB, which acts in the regulation of DNA modifications, including DNA phosphorothioation. These proteins show similarity to the N-terminal domain of ParB, a DNA-binding component of the prokaryotic parABS partitioning system, and other members of the ParB/Srx superfamily.
Statistics
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PSSM-Id: 319270
View PSSM: cd16413
Aligned: 98 rows
Threshold Bit Score: 106.273
Threshold Setting Gi: 110166787
Created: 2-Mar-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:
  • Comment:Putative active site residues by comparison to ParB N-terminal domain-containing superfamily proteins such as Osa and Srx

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                # #                                                                     
gi 653177302  39 FDIRQLVSERGId---SYLGIQRDLDpKRVREIAQYVKGTDaTFPTAVVLAVPekcvtiespcsaddrfvrmtlsnypqg 115
gi 309397190   6 LQDFVTVSRVRRddeqELSGYQRPEAlAHIQEIRAYLEAPSpMIPNSIVLAFDsrvrfepdkgkta----fpyvrtgtvv 81
gi 675289602   3 IASIDRVKRDENg---RLQGFQRPLVsKHIREIRDYLERPDsVMPNAIVLAFTngvrvvs----------------dtga 63
gi 670623809  35 FATISRVRRDEEg---ALRGYQRPEVfSHIDEIRRFIEGPNpMIPNAVVLAFNssvhfepadtefhp---egysrtgtlr 108
gi 663185347  34 FAAVSRVRRDGDs---NLQGYQRPEVlSHIRGIRRYLESDNaMLPNALVLAFDesvrfesgarraag---vdysvpgelv 107
gi 705647024  32 FAEIERVGREENg---QLRGFQRHQIaSHIKEIRDYLRRDDaLLPNALIVAFIggvkikd----------------kgdg 92
gi 550937037  30 VRRIARIERAGRdaggVLSGFQRPQIaAHIREIRDYLEKPTaILPNPIVVAFTgraslrpvg-------------gagsg 96
gi 553597382  29 ISKIAAISRIRRge-eSLVGYQRPEVrNHIREIQRYIESANpMIPNPVIIAFDkrvrfepltd----------nddmghl 97
gi 684618340  26 IEETCQVSRIFRddsnKLMGYQRTEVkNHVGDIANYITQDGaIIPNSIIIGFNsrttcre-----------------idg 88
gi 380729593 180 VPSFATVSRVRRte-gVLEGYQRPEVlAHVTAIREYMESAGaLVPNAVVLAFDsrvrfealpgeg------egarhghlv 252
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #  ##                                                          
gi 653177302 116 eddPEEAVYYRHIARVIDGQHRIRGLEGYAGTDFDVNVs--IFIDADIADqaSIFATVNlaqtkVSKSLV---------- 183
gi 309397190  82 iplAKDISDSDKPGFVVDGQQRLAAIRDADISRFPIFVt--AFITNDVRQqtEQFILVNst-kpLPKGLI---------- 148
gi 675289602  64 yveIEVDVSLGPVGFVVDGQQRLSAMAGLPERDFQLLVs--ALICETPEElrRQFILVNnt-spLPKSLI---------- 130
gi 670623809 109 vpfEEEMLDEDKPAFVVDGQQRLAAVRDSNVDSFPLSVv--AFITDDVAEqtDQFILVNst-kpLAKGLV---------- 175
gi 663185347 108 ipvDESLADEDKPALIVDGQQRSAAIRDADLAEFPVAVvgfIADNHDDQR--SQFILVNst-kpLPKGLI---------- 174
gi 705647024  93 vvdIEIKVGNEKPGFVVDGQQRLSALSGLAKSGFQVFVs--ALICKDYNElrQQFVLINnt-rpLPKTLI---------- 159
gi 550937037  97 iqrLTIDLSDGAPGLIVDGQQRFTALNEIADRDFELLVsgfICDGAEELQ--RQFILINnt-rpLPKALVyellp---qv 170
gi 553597382  98 vipFSEDKDFEKPGFIVDGQQRTAALRDAEINSFMMPVs--AFIANDAEEqrEQFMLVNst-kpLPKTLL---------- 164
gi 684618340  89 eifELDIPSGELTGVLVDGQQRVAALRESGRDDFHLSVc--AFINDDVEFerQQFLLINsa-kpLPRSLIyellp---hs 162
gi 380729593 253 iprATAPDAPDAPGFIVDGQQRLAAVRDASVTAFPLACt--GFVAETVGQqaEQFILVNst-kpLPKGLIhellpsttaa 329
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 653177302 184 --YDLFELSKSRSPektc-----hsvvVALESTKGSPLYRKIKRLGkat------------pgRYSETLSQAtavagvlq 244
gi 309397190 149 --YELLPSTDAQLPsplhrrklpallmERLNLDADSPLAGRIRTTT-----------------NPTGTIKDNsi------ 203
gi 675289602 131 --YELLPAIDGLPKrmtara-raarvvELLNFDSRSSLQGQIKQHT-----------------NPTGIIGDTal------ 184
gi 670623809 176 --YELLPNTESRLPsnllkkrfpsqllTILNAKRHSPFRGLIQTPT-----------------NPSGIIKDNsi------ 230
gi 663185347 175 --HELLPETSGHLPptyarkrlpaqlmTRLNTDGQGPFYGRIASPTspd-----------gniKDTAILRMLehslfe-- 239
gi 705647024 160 --YELLPTVEGLPErfttrk-fsarivDRLNYTRRSSLYGEIRQHT-----------------NPKGVLSDTamqklvmn 219
gi 550937037 171 sdLPLRMSNRSQAAll----------tEALNYRADSSLRGLIRQQT-----------------NPKGIIRDTvl------ 217
gi 553597382 165 --YELAPHTHGRLPsdlqmr-kfpsllTQRLNFGEGSLAGRIKTATnpd-----------gviADNSMIKMIdaslre-- 228
gi 684618340 163 tgVFKEELTRRRLPsl---------ivQLLNYDAKSPLQGVIKLTT-----------------NPHGIIADNsmmkml-- 214
gi 380729593 330 lpAALERKRLPAQIl------------ARLNLDDGSSLRGLVITQTcprstgktggkhfsaviKDTSLLSALeds----- 392
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                                                                       
gi 653177302 245 yickdkiqiiqdrqigrrggtfppaqpvdanklvlRPFFTEGRD-----------------ADLTNLIWNFFEAVQERW 306
gi 309397190 204 ----------------------------------lKMIENSLSDgvlfhflrpqtalgadvAPMLEILHHFWAAVARVF 248
gi 675289602 185 ----------------------------------qKMVMNSLSDgycrtvm----dhengeERCFMAISEFFSAVQEVF 225
gi 670623809 231 ----------------------------------lKMLETSLNEgvlyrfrs-edgaggaiDAMVTVLCAYWGAVSDVF 274
gi 663185347 240 -----------------------------galyqyRNPEDGSGDv----------------DRMLLHLRSFWAIVKDTF 273
gi 705647024 220 ----------------------------svsdgaiREFLKHDDYe----------------DRAYEIINSFFGAVKSVF 254
gi 550937037 218 ----------------------------------qRLIMASLTDgalrlha---gddrtlmENGSRLISEYFHAVQTVF 259
gi 553597382 229 -----------------------------galyrfRDPATGLGDe----------------EKMVKLLNNFWSAVETVF 262
gi 684618340 215 -----------------------------dnslreGALYDFRTPksdki-------sasvcESMIDLLNQYYSSMREVF 257
gi 380729593 393 --------------------------------ladGTLYDLERTga-------------gvDAMVSRVSAWWAAVASTW 426

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