3K1Z,2OM6


Conserved Protein Domain Family
HAD_dREG-2_like

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cd16415: HAD_dREG-2_like 
Click on image for an interactive view with Cn3D
uncharacterized family of the haloacid dehalogenase-like superfamily, similar to uncharacterized Drosophila melanogaster rhythmically expressed gene 2 protein and human haloacid dehalogenase-like hydrolase domain-containing protein 3
The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
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PSSM-Id: 319852
View PSSM: cd16415
Aligned: 17 rows
Threshold Bit Score: 117.007
Threshold Setting Gi: 55981487
Created: 9-Mar-2016
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #####                                                                       
3K1Z_A        3 LLTWDVKDTLLrlrhplgeayatkarahglevepsaleqgfrqayraqshsfpnyglshg---ltsrqwwldvvlqtfhl 79
2OM6_A        6 LVTFDVWNTLLdlnixldefshqlakisglhikdvanavievrneikkxraqase-------------dprkvltgsqea 72
gi 6093951    9 LITFDVTNTLLqfrttpgkqygeigalfgarcdnnelaknfkanwykmnrdypnfgrdtnpqmewqqwwrkliagtfaes 88
gi 2497160   23 IITFDAYNTLYatklpvmeqycivgrkygikanpstltnnfphvfkklkedypqygk--------ysgikpeqwwsilir 94
gi 55981478   4 ALTFDVGNTLIlasprfwllpllearglrprgdvrkaaleafrfyeenhlkardle----------talglwrefhrrll 73
gi 2660676   11 CITVDVTGTLIaykgelgdyycmaakaiglpcpdykrvhegfklaytdmaqkypcfgfhak-mpnivwwktcvrdsfvka 89
gi 15227309  79 ALLVDAVGTLLvpaqptaqiyknigekygveyseaeiltryrrayqkpwggshlr------------yvndarpfwqyiv 146
gi 55981487   5 AITFDFWGTLFtegeaflekvmparyeilldalseaghpvdeaevreayrqaslafeeaw---kagehmpvyervarifa 81
gi 30683719  44 GLLLDAGGTLLqlskpvhetyaslgqkyglkttpaeikegfkrvfsapwpeklr--------------yqgdgrpfwklv 109
gi 24639695  16 LVTFDVTDTLLrledplrqyhqtaeefgvtgvdrrrleqcfrqqfkamssehpnfgryspg-ldwqrwwlqlvartfscv 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                            ##                         
3K1Z_A       80 agvqdaqavapiaeqlykdfshpctwqvldgAEDTLRECRTr----gLRLAVISNFd----RRLEGILGGLGLr-EHFDF 150
2OM6_A       73 lagklkvdvelvkratarailnvdeslvlegTKEALQFVKEr----gLKTAVIGNVxfwpgSYTRLLLERFGLx-EFIDK 147
gi 6093951   89 gaaipdeklhnfsnhlielyktsicwqpcngSVELLQQLRKelkpekCKLGVIANFd----PRLPTLLQNTKLd-QYLDF 163
gi 2497160   95 nvfapneipdemineilmrfegfdsyfvypdLIKFLKDLKSrh--pdVILGIVSNTd----PIFYKLLKNIGLfeTFSGH 168
gi 55981478  74 vgmgledhaealsrelvarwkdpatwplvpgAEATLKALKAk----gYPLAVVSNWd----ATLPEILEVVGLg-RYFDH 144
gi 2660676   90 gyeydeetfekifrriystfgsaapysvfqdSQPFLRWARRk----gLIVGLVSNAe---yRYQEVILPSFGLskAEWDF 162
gi 15227309 147 tastgcsdsqyfeelysyftteqawklcdpdAGKVFKAIKEa----gVKVAIVSNFd----TRLRPLLRALRCe-DWFDA 217
gi 55981487  82 llgaphdpglialtarrleessllaplkplpGVEVLKDLAKk-----YPLAIVSDTgmtpgRLLREHLKRQGL--DVFQA 154
gi 30683719 110 vseatgcsdndyfedvyqyyangeawhlpegAYETMSLLKDa----gVKMAVVSNFd----TRLRKLLKDLNVi-DMFDA 180
gi 24639695  95 dhglapeklekigqrlisvfrtsacwshvngAQELVQNVRNa----gKCVGIISNFd----SSLPQVLDAMGFa-GKFDF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                                    ##   ##                          
3K1Z_A      151 VLTseaagwpKPDPRIFQEALrlahx-------------epvvAAHVGDnyLCDYQGPRaVGXHSFLVvgpqaldpvvrd 217
2OM6_A      148 TFFadevlsyKPRKEXFEKVLnsfev-------------kpeeSLHIGDtyAEDYQGARkVGXWAVWInqegdkvrkl-- 212
gi 6093951  164 AINsyevqaeKPDPQIFQKAMeksglk----------nlkpeeCLHIGDgpTTDYLAAKeLGWHSALVhe---------- 223
gi 2497160  169 IYLsyelnlaKPDRAIFQYALddiiskqphllekytreeilqhCFHIGDelKNDLEGAEaAGWTGILLdrndkygfls-- 246
gi 55981478 145 LSVsalsgyaKPDPRLFREALealgv-------------speeAVHVGDa-EADLLGAEaVGMRALLFdplg-------- 202
gi 2660676  163 GVFsgiegieKPDPRIFTLALeragnn-----------iapeeVLHIGDsmRKDYVPAKsIGMHALLVdrfkteaakdw- 230
gi 15227309 218 VAVsaeveaeKPNPTIFLKACellev-------------npedAVHVGDdrRNDVWGARdAGCDAWLWgse--------- 275
gi 55981487 155 FSFsdetgfvKPKPEAFRVALealgv-------------apeeALHVGDlpQTDIKGAFgTGYPWAVQ------------ 209
gi 30683719 181 VIVsaevgyeKPDERIFKSALeqisv-------------dvnrAVHVGDdeGADKGGANaIGIACWLWged--------- 238
gi 24639695 166 ILTsyeagvmKPERGIFEIPLqrlqi-------------paeqALHIGNklDMDYEGARnCGWSGLLVsnadnp------ 226
                       250       260
                ....*....|....*....|.
Feature 1                            
3K1Z_A      218 svpkehilpsLAHLLPALDCL 238
2OM6_A      213 -eergfeipsIANLKDVIELI 232
gi 6093951  224 --------ksYAYLVKKYGED 236
gi 2497160  247 nsiskpmrdeYKLSIDKIDNN 267
gi 55981478 203 ------enpkALPRLERVLDY 217
gi 2660676  231 ieagaivlpdLVAVQQLLESD 251
gi 15227309 276 -------vtsFKQVAQRIGVK 289
gi 55981487 210 ----------YVGLREVNGEV 220
gi 30683719 239 -------vqtFSDIQKRILVS 252
gi 24639695 227 -----hsfasLSSLLEALKTQ 242

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