1PW5


Conserved Protein Domain Family
HAD_Pase_UmpH-like

?
cd16422: HAD_Pase_UmpH-like 
Click on image for an interactive view with Cn3D
uncharacterized subfamily of the UmpH/NagD phosphatase family, belongs to the haloacid dehalogenase-like superfamily
This uncharacterized subfamily belongs to the UmpH/NagD phosphatase family and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.
Statistics
?
PSSM-Id: 319858
View PSSM: cd16422
Aligned: 5 rows
Threshold Bit Score: 367.533
Threshold Setting Gi: 46580350
Created: 7-Mar-2016
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #####                           ####                                        
1PW5_A         7 LFILDXDGTFYlddsllPGSLEFLETLkekNKRFVFFTNNSslgAQDYVRKLRNXGvdvpdDAVVTSGeITAEHXLkrfg 86
gi 89994594   22 LFLFDMDGTIYeedrlfEGTLELLDYIhniGGEYIFITNNSsksVVDYVEKVNRLGikaerDNFFTSAqATIVYIKenyp 101
gi 19704590   20 CYLLDMDGTIYlgneliNGAKEFLEKLkekKIRYIFLTNNSsknKNRYVEKLNKLGieahrEDIFSSGeATTIYLNkkkk 99
gi 104162018  11 LFVSDMDGTFYlgntllPGSLDFAMAVhrlGARLVFLTNNSsrtPEEYIRKLEKMGvdrklFQVYTSGeATISFLKrdfa 90
gi 46580350    8 CFIFDLDGTVYlgddpiPGTVDFIRRNl-gKREIFFLTNNTsknLADYTAKLARLGidiglDRMLSPLlPLVDHLRdegi 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             #          
1PW5_A        87 ---rcrIFLLGTPQLKKVFEayghvi---deenpdFVVLGFDKTLTYERLKKACILLRKg-KFYIATHPDINCPSK-EGP 158
gi 89994594  102 ---kskVYCQGTKSLIKELSdagidvteqvsadidVVLVGFDTELTSDKIRNTCEILSTkdAPFIATNPDIRCPVS-FGF 177
gi 19704590  100 ---gakIFLLGTKDLEDEFEkagfelvkernknidFVVLGFDTTLTYEKLWIACEYIANg-IEYIATHPDFNCPLEnGKF 175
gi 104162018  91 ---kkkAFLLSTPSVREMFEkggvml---ddfdpeVLVLAFDTSITYEKIRRAALLIRQg-IPYVASHPDINCPTE-EGP 162
gi 46580350   87 triypvGNANFTAFLRERMPelvftd----gddcqAVVLGYDTELTYRKLETSCLLLQRpeVLFLATHADKVCPSP-RGP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                #                       #######                         
1PW5_A       159 VPDAGSIXAAIEAStgrkpDLIAGKPNPLVVDVISekfgvpkERXAXVGDRLYTDVKLGKNaGIVSILVLTGETTPEdle 238
gi 89994594  178 IPDCGSICDMISKSvd-rePVYIGKPEPTMVDIVRkklnyslFETVVIGDRLYTDIMTGINaGVTSVCVLTGEATVNdiq 256
gi 19704590  176 MPDAGAMIAFIKASte-kePTVIGKPNSHIIDAIIekydlkkSELAMVGDRLYTDIRTGIDnGLTSILVMSGETDKKmle 254
gi 104162018 163 IPDVGSLISLFETStgrrpDHIIGKPDPAILKMVMedfdcsqEETVVIGDRLYTDIECGLKaEVDTFLVLSGETTRDmip 242
gi 46580350  162 LPDAGSFMALYETAtgrtpDLVFGKPNTILLKPLLkhf--tpEEMVMVGDRVYTDKVLAENaGMDFILVLSGETRREqla 239
                        250
                 ....*....|....*
Feature 1                       
1PW5_A       239 raetkPDFVFKNLGE 253
gi 89994594  257 qgsikPTYTFKNVKE 271
gi 19704590  255 ktiykPNYIFDSVKE 269
gi 104162018 243 --drhSYKVVENVGS 255
gi 46580350  240 dlerqPTLVLDDLGS 254

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap