4NHF,2BHM,2CC3,4AKY,4JF8,4KZ1,4LSO,4MEI,4O3V


Conserved Protein Domain Family
VirB8

?
cd16424: VirB8 
Click on image for an interactive view with Cn3D
periplasmic domain of VirB8 protein
This family contains the periplasmic domain of VirB8 protein which is an essential assembly factor of type IV secretion system (T4SS) channel proteins that are highly diverse in function relative to other bacterial secretion systems. T4SS proteins are important virulence factors for many Gram-negative pathogens, such as Agrobacterium, Brucella, Legionella, and Helicobacter. VirB8 is a bacterial virulence protein with cytoplasmic, transmembrane, and periplasmic regions. It is thought that VirB8 is a primary constituent of a DNA transporter. It is a crucial structural and functional component of the T4SS, with interactions between VirB8 and many other T4SS proteins, including VirB10, VirB9, VirB1, VirB4, and VirB11, as well as with itself.
Statistics
?
PSSM-Id: 319761
View PSSM: cd16424
Aligned: 271 rows
Threshold Bit Score: 56.1458
Threshold Setting Gi: 389596229
Created: 29-Dec-2015
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
dimer interfacedimerization
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ## ### ##        #  #  #                                      #             
4NHF_A        39 SYGEVVDRYWLNQYVLNRENYDydTIQLNYDTTALlsaASVQQEYYKIYDGENArd---kvLSNKARITVKVRSIQLng- 114
2CC3_A         5 TQEEAVVNASLWEYVRLRESYDadTAQYAYDLVSNfsaPMVRQNYQQFFNYPNPtsp-qviLGKHGRLEVEHIASNDvt- 82
gi 75388609   81 SSEDALIQGALYDFVGACNTFDpkRKQQLSDACHLfitPDIAREYEQLINPENPdnp-yltLDAKDWIEAQAYGMNKvg- 158
gi 75391351   81 DKEQAVIEGVLFDFIRACNTFDprRKQQLSDTCHTymtRNVAVEYEKEISPDNArnp-yasLGENDWIEAQPKRMNKig- 158
gi 81763274   84 TGQESFVQSQVYDFIMYCNTFDpdWRQHFADLCRLhstQTVAGQYDAETSPDNPnnp-yyqLGQGGRRYPKITGITSlg- 161
gi 385182935  89 SSKDAVIESELARYVTERYTLDraFRQDHIDYVRLhsaSDVADRFNHEMDAKNKd------NPYYAIAETTVRRVKDqri 162
gi 674298848  75 KAQILLMETLSRQYVSLRETIDlqTEDVRWKQLSLmtaSQLNEEFMSLMKPENPdspfkkrQESHVTREVQILSSTSlap 154
gi 725880685  83 TGLESFVESDINTFITACNTFDpnWRQRNADLCRLhstVSVAKQYDHETAADNPdnp-yykLQPGARRYPVITAINPlgd 161
gi 742259240  86 VAEEAMVQSNLHAFVRDCNTFDpaWRQHLSDLCRLrstPAVAEQYDREIAPDNPqnp-yyqLPSGGKRRAQITGFSKle- 163
gi 772899914  95 LSKDAIIDGEIARYLTERFSLNraFRDDMVRYVDLhstPDVAAAFDHEMDVNNRdn---pyYKLPQGVSRKVKDVRVrvf 171
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1                                                       #  ##      ##           
4NHF_A       115 ------lgQATVRFTTQQldssgattgPKQHQIATIGYTYvga-pmkSSDRLl----NPLGFQITSYRSDP 174
2CC3_A        83 ------pgVQQIRYKRTLivdg--kmpMASTWTATVRYEKvts--lpGRLRLt----NPGGLVVTSYQTSE 139
gi 75388609  159 -------dVYQVSFRSYLhkwg-tkdpVVTNYVANVKIDNtlk-praLGDRWv----NPLGTLATVYRKSE 216
gi 75391351  159 -------dEYQVIFISTNhkwg-dkepRVTSYLATIKVAHtmi-praLGDRWe----NPFGTLATLYRKSE 216
gi 81763274  162 ------kdAYQVSFQSITekag--sppKTDYYTALVRYTFtfk-plaLGDRWe----NALGYATTAYRKDQ 219
gi 385182935 163 rildrddhKAEATFTTYNdgn---ddnKTVYWHVLFRYDFvkq-altPQNRYi----NGTGFMVTGFEPNT 225
gi 674298848 155 s----apnIFQVEWISRDrhkg--qviGQGHWISTLTVSLephevsiEDQYI-----NPIGFTVTHYTLAQ 214
gi 725880685 162 -----krdAYQVEFKSVTkdkd--gveTSEYYTAMIRNIYtfk-plaLGDRWe----NPLGFASTSYSKSQ 220
gi 742259240 164 ------dnAYQVMFKSLTerpg--aepLVDYFTALVRFNFt-----aQPMALgdvweNPLGFVVTAYRRDQ 221
gi 772899914 172 drdakkgeATLVTVEDGSga-----dnKPIYWHVRFQYDVvkq-alsPADRYi----NSTGFVMTAYQPNT 232

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap