3UB1


Conserved Protein Domain Family
TcpC_C

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cd16428: TcpC_C 
Click on image for an interactive view with Cn3D
C-terminal domain of conjugative transposon protein TcpC
This family contains the C-terminal domain of conjugation protein TcpC and similar proteins. TcpC is required for efficient conjugative transfer, localizing to the cell membrane independently of other conjugation proteins, where membrane localization is important for its function, oligomerization and interaction with the conjugation proteins TcpA, TcpH, and TcpG. C-terminal domain is critical for interactions with these other conjugation proteins. TcpC has low level sequence identity to proteins encoded by the conjugative transposon Tn916, which is responsible for a large proportion of the tetracycline resistance in different pathogens.
Statistics
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PSSM-Id: 319759
View PSSM: cd16428
Aligned: 179 rows
Threshold Bit Score: 47.9918
Threshold Setting Gi: 552525676
Created: 15-Mar-2016
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
trimer
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Comment:Each protein molecule contains a C-terminal domain and a Center domain, separated by a linker; the 3 together make a non-covalent trimer related by a molecular threefold axis, generating a triangular-based pyramid in which the Central domains form the core of the pyramid and the C-terminal domains the apexes
  • Structure:3UB1: Clostridium perfringens conjugation protein TcpC homotrimer; contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           #                   ###    ##                                
3UB1_A       149 NDADKTKKITDSVSQFFKAYyeqNQTQIDYFLVdg-aDIKGAGQ--KFSFNKI------DRINIYKLSd-----kEFLAI 214
gi 919190469 220 NDTDVRDELQENLEGFFEAYa-eTPDHLSRYVEpgahVTELPQGt-LSFHEVRdv---tVPVGSGNGDdv----rEATAT 290
gi 567775794 187 RDSATEAELRPQLEGFFKAYaagNQVDLQRYVAng-vTVDGFNGe-FTLAELKd-----VVVPPGDADs-----rEVTAV 254
gi 943865791 218 TDDAAAAELKPQLEGFFKDYasgDAAGLQRYVAag-kSLPSFGGs-FTFAELK------EVVVPVGGAt-----rEIQAV 284
gi 749671428 210 TDAAARDELLPRLERFFGAYa-eDPDYLSDFVEpg-aRVDRLPPdtLEFVELV------DVAVPASGSgdn-dgrQVTAE 280
gi 516171556 207 VDTEARAELESMLPAFFEAYs-aNPDHLSQYVEsg-vRIAPLPAdsLVFEKLDevavpaRTAAAGDEDv-----rQAVAE 279
gi 502658701 222 SDEAAETELRTPLADFFKAYaasDNASLQRYAAag-vTLEGFGGa-FTFVELK------NLDVPLVGGat----rEVTAT 289
gi 974811865 210 TDPQARSELEETIKNFFEAYa-qNHEHLDRYLApg-aDVTALPSgvLQFGSIV------DLKVPVAGSgtaedarAAQVT 281
gi 516215901 206 NDSGTRDELEPRLKRFFEAYaetPEHLPSYLADg--aHVAQLPAgsLKFAGLEe-----LVVPAKTANgnd-dvrQATAT 277
gi 516220103 207 ADSQAREELEPVLTSFFEAYa-eTPEHLTRYVEng-aSVARLPQgsLEFGQLDdv---vVPARTEVGEdd---vrQATAT 278
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
Feature 1                                # #######               
3UB1_A       215 VDLNVDs-----------------FGNAIKQGFNLTVVQegdkFLVKT 245
gi 919190469 291 VVWRLAdag-------------deTPADLRQTYQLTVVKdggnWYVRD 325
gi 567775794 255 VVWAVSsgdvaavatpsadpvsqpAGLEQAYQLTMEKQGg--kWFVRD 300
gi 943865791 285 VEWLVPtasasaap---nttdpgaVGGRLEQAYRLTVEKqgdkWYVAD 329
gi 749671428 281 VVWVPAeag-------------edTSAELTQSYELTVVKdgenWYVRE 315
gi 516171556 280 VVWRVPggsg----------gsdgEGATLTQSYQLTVVEsggkWYVRD 317
gi 502658701 290 VVWGVPsgasptad--ptpsdpgdMSGKLEQAYLLTVVKqgdkWFVKD 335
gi 974811865 282 VVWLLPded-------------geDAAELTQSYSVTVVKdgsdWYVRD 316
gi 516215901 278 VKWRLAgek-------------gdDPAELTQSYRLSVIKdgddWKVLD 312
gi 516220103 279 VEWRIPgg--------------ggEAAALTQSYRITVVRsdgeWYVRD 312

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