C-terminal domain of conjugative transposon protein TcpC
This family contains the C-terminal domain of conjugation protein TcpC and similar proteins. TcpC is required for efficient conjugative transfer, localizing to the cell membrane independently of other conjugation proteins, where membrane localization is important for its function, oligomerization and interaction with the conjugation proteins TcpA, TcpH, and TcpG. C-terminal domain is critical for interactions with these other conjugation proteins. TcpC has low level sequence identity to proteins encoded by the conjugative transposon Tn916, which is responsible for a large proportion of the tetracycline resistance in different pathogens.
Comment:Each protein molecule contains a C-terminal domain and a Center domain, separated by a linker; the 3 together make a non-covalent trimer related by a molecular threefold axis, generating a triangular-based pyramid in which the Central domains form the core of the pyramid and the C-terminal domains the apexes
Structure:3UB1: Clostridium perfringens conjugation protein TcpC homotrimer; contacts at 4.0A - View structure with Cn3D
Jiyao W et al.(2023). "The conserved domain database in 2023.",