Conserved Protein Domain Family
TraB

?
cd16430: TraB 
TraB is a homolog of VirB10 which forms part of core complex in Type IV secretion system (T4SS)
This family contains TraB (VirB10 homolog) and a component of the type IV secretion system (T4SS), and similar proteins. T4S system is employed by pathogenic bacteria to export virulence DNAs and/or proteins directly from the bacterial cytoplasm into the host cell. It forms a large multiprotein complex consisting of 12 proteins termed VirB1-11 and VirD4. VirB10, interacts with VirB7 and VirB9, forming the membrane-spanning 'core complex' (CC), around which all other components assemble. The CC is inserted in both the outer and inner membranes, playing a fundamental role as a scaffold for the rest of the T4SS components and actively participating in T4S substrate transfer through the bacterial envelope via conformational changes regulating channel opening and closing. TraB is localized similarly to related proteins in other systems, but unlike in other systems, Neisseria gonorrhoeae TraB does not require the presence of other T4SS components for proper localization. It has been shown to be expressed with TraK (VirB9 homolog) at low levels in wild-type cells, suggesting that gonococcal T4SS may be present in single copy per cell and the small amounts of these proteins are sufficient for DNA secretion.
Statistics
?
PSSM-Id: 319756
View PSSM: cd16430
Aligned: 122 rows
Threshold Bit Score: 114.141
Threshold Setting Gi: 332995601
Created: 30-Mar-2016
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
putative
Feature 1:putative oligomer interface [polypeptide binding site]
Evidence:
  • Comment:based on comparison to similar proteins

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          ##     ##   ## ####           # ##      ### #           # # # #     #  # # #  
gi 75445875  213 YIPSg----SFAKAMLIEGADANASvt-gNESTVPMQL--RITGLVEMPNs-kTYDATGCFVGLEAWGDVSSERAIVRTR 284
gi 500030876 248 WLSAg----TVIPTVLLTGQHVPTSss-aQSNPAPVLL--KIVDVGVMPNg-fTIDLVGCTVIGAARGSASTRRVEIRAE 319
gi 972503168 201 KIFAg----TTVKALLVSSVDAVCGvf-sNSDPVPVKL--RIIDNGHLPKy-lTAQLKGGLVIGSAFGNISNERVYIRLE 272
gi 685072974 166 AIPAg----TTVRALLISSIFAPAGmy-aPTNPIPVKL--RIMDVGHLPKg-vKAKLKGGILIASAYGDLSNERIHVRLE 237
gi 46400700  191 RTPAn----VSVRAILLSSVDAVCRld-aQSDPIPVKL--RLLDDAHLPGg-mKVKLKGCLIGASAYGDISSERVYMRLE 262
gi 641467139 196 YITTg----SFARGVLLTGVVVGTGtn-nAASPEPIMI--RLVDTSNFSKgykTKQIKEAILIGSCSGDISSERAKCRLE 268
gi 751432442 320 KLPKmtlmaGFQRATLVTGADVPTLq---KGNDLTRTVwfSTTGDMLIANg-hTENIKECIIQAAATGNFASASADIRLT 395
gi 696171036 313 DIAL-----GLSRAIMLNGVDASILgm-gRQEDAPVMF--SIMSKMSIANg-eYTNTKDCLVLGSAVGQMTVQKAQIRLD 383
gi 336481236 180 VIPAg----TIVRCVVVSGASVSTGig-tPMGSRKILL--KPTSNGWLPAg-vRVALKDSLIMCSATANLAEERVYVRGD 251
gi 927435571  24 TIPNn----SILSGKLITGLIGRIPldgqLTDPFRFSI--KIIKKSFYANrhvNNVLQDVIASGTASGDLRLSCVRASID 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # # #      ######       #      ###         #  #  #  # #  #                      
gi 75445875  285 NISCLk---DGKTIDMPI------KGHVsfrGKNGIKGEVVMRN-GKILGWAWGAGFVDGIGQgmerasqpav------- 347
gi 500030876 320 SISCId--qRGRAIEQPFia--avQGQD---GHSGIPAKLVTLY-GEVVKQSFWAGIYGTGAQtltqaatnrvs------ 385
gi 972503168 273 RMSLFt--pKGEGIEMEVag--yvSGED---GRFGLRGLVIDKS-TKMIKNAAFSGFLSGTGQilqsavskrps------ 338
gi 685072974 238 RLTQVr--kDGYFVETDVag--yvSGED---GGAGIRGVVVDRS-GRMVSNAAMSGFLSQLGQilqsgitrhs------- 302
gi 46400700  263 NLTQVn--lSGQAIETEVtg--yvSGED---GRFGMRGILVDRS-AKILKPALGSGILSGIAQtlqsacarps------- 327
gi 641467139 269 TVSLIn--nKGDIIEKKVeg--wlIGED---GRPGIKGIIVDKS-SNVARMAVLNGVLGGIAQffqnqatngifpi--sp 338
gi 751432442 396 KISCSavdeNGKYYKLVGnvkgwvYGEN---GKQGLKGRLVTKE-GELIEKAIPLALLEGAIKalenstkssstvyaypg 471
gi 696171036 384 KISCIftnkEGDKFIAEGqv--qgWASDe-nGQLGVQGVLITQE-GKVLRASLPLAAVQTALDyitrsatnvvlp----t 455
gi 336481236 252 RMNLTy--pDGYTITTEIaa--yvSGED---GQEGVRCALIDKN-WSSTFWAGLASGVGEIGKamqsgnplldlp---kl 320
gi 927435571  98 SITFIf--eDGTISDHKIsdi-gfITNEy--GLPCIEGELITDAaQYLMTTSLLSGLSSAAKAvseaqktltsn------ 166
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
Feature 1                                   ##########     # # ###  #   #    ##### 
gi 75445875  348 glgataaygaGDVLKMGIGGGASKAAQTLSDYYIKRAEQYHPVIPIGAGn-EVTVVf--qDGFQLK 410
gi 500030876 386 gdvvydgtyfKNTATSSLAGGSSTAFDKIADFYLQLADEARPYLEMHGGieGVDLIv--qRGVSLK 449
gi 972503168 339 dswnnytavgRDMLKQGAADGAGNAFDMLADYYIRRAEQVQPVLQVNAGr-VVDITf--tHGTSLG 401
gi 685072974 303 tykvenntlnYDVLKQSAVGGSTNALDMLAEYYLKRAEQIQPVIQVNGGr-IVDVTf--nIGSEVG 365
gi 46400700  328 -ketintyslSSDFAQNTVAKTSDAFSLLASYYIKRAEQVQPVLQIDAGr-LVDVTf--tQGFSMG 389
gi 641467139 339 mtgqqnalkaQDALKAGVYSGTGNALEKLADFAIKRAESMSPVIVVGSGr-VVDVVf--rKGFDLI 401
gi 751432442 472 ttgtstmnniQDSFTEGTTKTASTTLDKFSDYYLMILEQLNPTIELKAGr-ETTIGfeggEVFQLE 536
gi 696171036 456 tgtptgyqnlNASFGTGGSNAASQTLGRLIQIYEKYLQNLNPVINVRGGr-EVTLMf--kGGEKIA 518
gi 336481236 321 gktdtsfiinLDTLKQGGIQGGSTALDKMTEHLLKEKEKNAPFLILDSMr-HVDLIf--lHDCEIG 383
gi 927435571 167 nngsssssltGSPSKLSAYSALSGGVDDAKDWFNQRTKSSFDVIFVPSGk-SVKILt--qEQINID 229

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap