Conserved Protein Domain Family
beta_Kdo_transferase_KpsC_2

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cd16439: beta_Kdo_transferase_KpsC_2 
beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase KpsC, repeat 2
KpsC is a beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase. It is part of the ATP-binding cassette transporter dependent capsular polysaccharides (CPSs) synthesis pathway, one of two CPS synthesis pathways present in Escherichia coli. The poly-Kdo linker is thought to be the common feature of CPSs synthesized via this pathway. CPSs are high-molecular-mass cell-surface polysaccharides that are important virulence factors for many pathogenic bacteria. KpsC contains a domain duplication.
Statistics
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PSSM-Id: 319747
View PSSM: cd16439
Aligned: 160 rows
Threshold Bit Score: 327.478
Threshold Setting Gi: 916251508
Created: 22-Mar-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170705    365 SACVVWGVKgeqqwra-----eaqrksLPLWRMEDGFLRSSGLGSdllpPLSLVLDKRGIYYDATRPSDLEVLLNHSQLt 439
gi 515584182  113 DVFIVWGFNelysvkl-----yskktnIKTFRMEDGFIRSADLGSahtvPYSLVLDKTGFYYDCHQPSDVENLLNNYIGs 187
gi 490940046  132 EVVVIWGYTesfwlrm-----ylnlrnIPIWRMEDAFIRSASLGAthstPYSLVIDKTGLYYNGKKPSDIENLLSHYDFn 206
gi 920599258    3 ESKELLSYAek--------------rsFPLFRMEDGFIRSSELGAehttPLALVLDKTGIYFNANQPSDLENILNDSDFd 68
gi 446083608   79 KTIYNWGAEippyi--------kelknLKIVRVEDGFIRSIGLGAehilPMSLCFDDCSIYYNAQEESRLEKLITTYRVn 150
gi 672608478  122 KKIVVWGYNdprffsf-----fikkmkLNVLRMEDGFLRSFDLGAshatPYSLIVDGVGLYFDPRSESEIERLLNSYEFt 196
gi 163260341  144 SAFFFWGFTeprmvrw-----yastrhIPTFRMEDGFIRSAALGAshatPYSLIVDSKGLYYDPNRESDIEAILNEYNFs 218
gi 504234963   96 LKIFCWGNKypktfpkntyfskskkkkIQVSRIEDGFLRSIGSGVlhtrPASLCVDDLGIYFDASRPSRLEEIINDPEEl 175
gi 625305358  121 SVFIFWGMTepwlvcq-----yaklkrMPILRMEDGFLRSANLGAahstPYSLLLDSRGIHYNPDGNSDLRDVLNNYEFs 195
gi 916251508  121 RDLMIWGYNdaslwlt----rlakrlgYNVYRMEDGFVRSVELGAnhstPYSLVVDNKGLYFNPREPSELEDILNSDPRl 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170705    440 l--aqQMRAEKLRQr-LVESKLSKYNlgadfsl--paeakdkKIILVPGQVEDDASIKTGtvsikSNLELLRTVRERNpH 514
gi 515584182  188 s--seLETAESLLKk-FVDSNLSKYNlpssstekitdkiktkKRVLVIGQVDSDQSIKRGnpkniNSEELVKIAREENpS 264
gi 490940046  207 kdeklKKDAQKILDy-IINQDITKYNppvvchd---ntlkikKRILVVGQVDNDSSLRYGnpdkwTMEDMVRLAKRENpT 282
gi 920599258   69 ad-avLMQQAKALLqvLRLLKVSKYNlgslapaheilgpkykKRVLVLGQVELDAGVRYGmagdwDSASLIRLARSENpQ 147
gi 446083608  151 p--yeVEKARRIINk-IKTNKISKYNitgttii--knlpknkKKVLVIGQVEEDQSIKYGashgiNNKLLLHKAIAENpG 225
gi 672608478  197 k--knIDDSRECLKl-LHDLKLSKYNsqgiiqrd-evdykfsRRVAVIGQVDGDQSIRLGninrwSIEQLIKLAKFENpD 272
gi 163260341  219 d--teLAAAEESLNl-IRALDIAKYNppsfnggq-gggikirRKIAVIGQVDNDMSIRLGnvdkwTMIELIRLAKFENpD 294
gi 504234963  176 sapelLKEAGVVASl-IRSGRLTKYYdpdpymerlrqnptgeKTILVIGQVEDDASLLKGkasvaSNYDLVKLARKENpN 254
gi 625305358  196 e--seLHHARECLDl-LSSMRLSKYNpptlnisk-gsgikirRRVAVIGQVDSDRSITLGnfsrwSMKEVIQLAKIENpD 271
gi 916251508  197 hdpefLGRARKHLDf-ILETNLTKYNglrgaaee-flsirrrEVVLVIGQVPGDASIVYGnpdrwTSESLVALARSENpG 274
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1170705    515 AYIIYKPHPDVLVGnrkgni-pteliaELADYQALDADIIQCIQraDEVHTMTSLSGFEALLHGKQVHCYGLPFYAGWGL 593
gi 515584182  265 ADVIYRPHPDVFLGyqksri-rkksieEYARLVSPNEPFISSLEsvDHVYTISSLSGIEAVLRGIKVTTLGAPFYSGWGL 343
gi 490940046  283 AEILYRPHPEVYEGfqkskl-kkenieNYAKVISPDEHIIELINrvDHVYTLTSLTGLDALLRGKEVTVLGTPFYAGWGL 361
gi 920599258  148 AEILYRPHPEVIRKfrenst-dleelkKICRVITEDIAVNELFQhvDRVYTISSLSGFEALIHGIPVTVVGAPFYAGWGL 226
gi 446083608  226 AMIIYRPHPDVNNGlrknisnpeksnsICHILDDKNIDLCWLLDniDHVYTITSLTGFEALLRGKKVTTFGTPFYAGWGL 305
gi 672608478  273 AEIIYRPHPDVYNGfqksil-kkrrvaKYCTIVSPTSNQIEFLNsvDHVYTITSLSGLEALLLGKKVTVVGQPFYAGWGL 351
gi 163260341  295 AQIVYRPHPEVYKGyqkskf-rarvvtAICEIANPDVPLGQFLGtvDHVYTITSLSGLEALLRGKKVTVVGAAFYAGWGL 373
gi 504234963  255 ARVLFRPHPDYWSGirkrig-kergykDLCHVVPPSVSLYELFSvsDHVYTITSLSGFEALIYGLKVTTLGAPFYSNWGL 333
gi 625305358  272 ADIVYRPHPDVYKGyqrsrf-aarsvqNICEIVDPEIALSEFLDtvDQVYTLTSLSGLEALFRGVKVTVLGAAFYGGWGL 350
gi 916251508  275 CDIIYRPHPDVYNKphlyke-rrgviaKMATIVPPTVGLLDLLKsvKRVYTISSLVGMEAVMRDIPVTTVGLPFYAGWGV 353
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1170705    594 TVDehh-------cprREQKLTIADLIYQTLIVYPTY 623
gi 515584182  344 TDDrve-------isrRNRNLNLVEFFNIAYILYPKY 373
gi 490940046  362 TDDrck-------fkrRHRKLSLLELFSAAYILYPDY 391
gi 920599258  227 TDDral-------vprRRRVLTLEQLFCGAYLLYPRY 256
gi 446083608  306 TDDrgl-------irnRNIKRSIEEVFFCAYILYPTY 335
gi 672608478  352 TDDrve-------vprRNRSLKLEELFYAIYLKYPRY 381
gi 163260341  374 TDDrvk-------lprRTRQRSLIELFAAIYLKYPKY 403
gi 504234963  334 TDDrvk-------lrrRNKSRSIEQLVAAAYLKYPVY 363
gi 625305358  351 TDDrfdf-----rrydRNRSRTLEELFAAIYLKYPRY 382
gi 916251508  354 TDDqcserrggaayrrRRAKLSSLQLFAGTYLLYAKY 390
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