Conserved Protein Domain Family
beta_Kdo_transferase_KpsC_1

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cd16440: beta_Kdo_transferase_KpsC_1 
beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase KpsC, repeat1
KpsC is a beta-3-deoxy-D-manno-oct-2-ulosonic acid (Kdo)-transferase. It is part of the ATP-binding cassette transporter dependent capsular polysaccharides (CPSs) synthesis pathway, one of two CPS synthesis pathways present in Escherichia coli. The poly-Kdo linker is thought to be the common feature of CPSs synthesized via this pathway. CPSs are high-molecular-mass cell-surface polysaccharides that are important virulence factors for many pathogenic bacteria. KpsC contains a domain duplication.
Statistics
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PSSM-Id: 319748
View PSSM: cd16440
Aligned: 116 rows
Threshold Bit Score: 281.684
Threshold Setting Gi: 601179479
Created: 22-Mar-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532587704  56 VIGWGLKptsvsarqyaQRHQLIYIALEDGFLRSLGLgvngfqPHSLVVDETGIYYDASRPSDLENWLNTasfnneeLEQ 135
gi 440038549  58 ILSWGGRapakmaariaRFRGLRHWHLEDGFLRSMGLgksgaiPLSIVIDDLGLPVDANSPSRLERLIEGag---eaGDL 134
gi 495396645  72 IVGWGEKplarmarrlaKLRGLPYWALEDGFLRSVGLgkagapGVSIIADDVGIYFNAAKPSRLERLVEApvt-dqdLCR 150
gi 499901339  34 VVGWGRKpsghraialaSKRKLPFLLLEDGFLRSVERsg---pPLSLIVDDIGIYYDASAPSRLETLVREpls-eeqVRR 109
gi 505155913  67 VVSWGNGplsrlarlyaRVLRLPFWTVEGGFLQSTGPda--asPISVIADDLGIHFSARQPSRLEALLQDasf-dadVRR 143
gi 518797598  91 VVGWGRRwsglratrlaAGTATTAWLVEDGFVRSVGRfd---tSLSYLIDRQGVHYDADHPSDFEDLAKLplt-aaaRSR 166
gi 798774329   9 FVGWGRKwsgrraveiaQSHGAKFLLLEDGFLRSVGRqd---rSLSVVIDDMGVHYDASKLSRLEQLISSdit-pvqADR 84
gi 916611909  51 VLGWGRKasgfkaikqaQAKGLPFWLLEDGFVRSLGRed---dSLSLVQDDLGIHYDATEPSRLESLIPQpls-dqqQLR 126
gi 916816853  34 FLGWGRKrsglralkaaQRFSRAFLLLEDGFLRSVGGng--qrSYSLVSDDEGIYYDASCPSRLERLIRKpls-daqSAR 110
gi 917054310  41 VAGWGAKttafyarlhaKARGLPFLTLEDGFYRSVGLgkqgtpALSFTLDARGPYFDARQESELEMLLLGplg-adiESR 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532587704 136 AERCMAlIARYRLSKYNhspdqp---indasrASVLVVDQTAGDASIhyggasasSFNQMLEAALAehp--daEILVKIH 210
gi 440038549 135 GRAIREqIVLNRLSKYNhlphrap-rieqtkkRRILLVDQVVGDVSVgralgsraSFEKMLADGLAsd----aQCLIRTH 209
gi 495396645 151 SRSIQQqIVEQRLTKYNhlpdypf-slapttgRSILLIDQVASDYSIagagadelTFRQMLHEALAvp---gaTVMVKSH 226
gi 499901339 110 TLLLMRaWRDGHISKYNhardyd----gplpsRFVLVVDQTFGDASVrhgladasSFQGMLQAALDenp--ecSVLVKSH 183
gi 505155913 144 ARDLRRwINRERLSQDGhgpegtf-rlrrsrrRRILLVDEVVGDSAVesagadaaTFARMWTAALAea---naDIIVKCH 219
gi 518797598 167 ARNVARvWRRLDISKYNdqrdga----mdfgvPYVLVIDQTFGDASIaygradaqSFQQMLAAALDenp--dhLVVVKTH 240
gi 798774329  85 ARKIMQlWREGRVSKYNaapels----relpkKYVLVIDQVRGDMSInygaasaeSFERMLARAQEdnp--nsDIVVKLH 158
gi 916611909 127 ADAIAEqWRRLNISKYNaapdyt----gelpdDFVLVVDQVAGDASIaygladaeRFRQMLTAALDenp--lsAVVLKVH 200
gi 916816853 111 ARLVMAmWRDGRLSKYNgsrdie---pdrlpaRFVLVVDQTYQDLSVqygnadacTFDRMLHAALDdnp--daQVLVKIH 185
gi 917054310 120 GRSLREfIVEKRLSKFNyvpedpvrldapeglPRILLVDQVAGDRSLlgagastaTFAAMQAQAEAlaregraAAFLKVH 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 532587704 211 PDViagkkqgh--llnaadhPRCRVIGEDLNPWALFDqvdhVYVVTSQLGFEALLAGKQVHCFGIPFYAGWGLTHDqlpc 288
gi 440038549 210 PDVmaglrkgy--ltddaskGDAILVGDEVSVASILDvideVWTVSSQFGFDALLRGIPVRCYAAPFYAGWGVTEDrfgv 287
gi 495396645 227 PDIvagfargy--ltqlageANVHVITENISPHALLDvvdeVWTVSSQFGFDALIRSVPVKTFGVPFYAGWGLTTDwadg 304
gi 499901339 184 PDVvrrrkrgyfeprkladhPRVKFILDDCRPARLLEqaeaVYTVTSQLGFEALIWGKRVRCFGMPFYAGWGLTDDalaa 263
gi 505155913 220 PDVvagrargf--lqplaqtMDVQFVDKAISTHSLLDmvdeVWTVSSRLGLEALLREIPVVTFGMPAYAGWGLTADraeg 297
gi 518797598 241 PDTasrkrkgyfdiralqrhDRIRLITAPCHPVGLIVraaaVYTVTSQIGFEALIRQKRVRTFGMPFYAGWGLTDDalap 320
gi 798774329 159 PDVytnaakshfdpvklgkmERVHVVAENCHPISLIEgaqsIYAVTSQVGFEALIWGKPVHVFGMPFYAGWGLTQDdqia 238
gi 916611909 201 PDAytrakagh-fdlatlkhPRLKVIAENCHPGRLLSnarmVYTVTSQMGFEALVWGKPVRCFGMPFYAGWGLTHDvlda 279
gi 916816853 186 PEVamgrkkgyfdvarlagmPRVTVIADDRHPAALLEhaqaVYVATSQMGFEALLYGKPVHVFGTPFYAGWGLTHDyqpa 265
gi 917054310 200 PDVvagyak-----gmfgapSPLTRLAPEAGPHALLDeideVWTASSQLGFDALLRGRRVVTFAAPFYAGFGLTEDrpdd 274
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 532587704 289 hr----------rrvkrTLVEVFAAAYLRYCRYANP 314
gi 440038549 288 ytkaa---lagrrtklrTVDQIAAAAFSLYPTYRDP 320
gi 495396645 305 piara---afsrrtsrpTLDRFVAAALLHYSRYVDP 337
gi 499901339 264 pa----------rrksaTLEQLVHASLVRYPRYRDL 289
gi 505155913 298 avaat---arcrrgrhvSIDEFAAASFFQYSRYVDP 330
gi 518797598 321 pv----------rrqpiSLDQLVYAALIAYPRYVDP 346
gi 798774329 239 pd----------rrgraSLEQLVHAALVAYPEYVDP 264
gi 916611909 280 pirr-----rqaavvkvRLQQLVHAVLVSYSRYMDP 310
gi 916816853 266 ps----------rrtpcTLEQLVHAALIDYASYLDP 291
gi 917054310 275 aapharaalarraakrlSLDALAGAAIGLYPRYFDP 310
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