1WGM,1T1H,2BAY,2C2V,3L1Z,4WZ2,4WZ3,4XI1


Conserved Protein Domain Family
RING-Ubox

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cd16453: RING-Ubox 
Click on image for an interactive view with Cn3D
U-box domain, a modified RING finger
The U-box protein family is a family of E3 enzymes that also includes the HECT family and the RING finger family. E3 enzyme is ubiquitin-protein ligase that cooperates with a ubiquitin-activating enzyme (E1) and a ubiquitin-conjugating enzyme (E2), and plays a central role in determining the specificity of the ubiquitination system. It removes the ubiquitin molecule from E2 enzyme and attaches it to the target substrate, forming a covalent bond between ubiquitin and the target. U-box proteins are characterized by the presence of a U-box domain of approximately 70 amino acids. U-box is a modified form of the RING finger domain that lacks metal chelating cysteines and histidines. It resembles the cross-brace RING structure consisting of three beta-sheets and a single alpha-helix, which would be stabilized by salt bridges instead of chelated metal ions. U-box proteins are widely distributed among eukaryotic organisms and show a higher prevalence in plants than in other organisms.
Statistics
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PSSM-Id: 319367
View PSSM: cd16453
Aligned: 28 rows
Threshold Bit Score: 44.8009
Threshold Setting Gi: 74735248
Created: 20-Apr-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
U-box domain, a
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:U-box domain, a modified RING finger [structural motif]
Evidence:
  • Comment:The U-box is a modified form of the RING finger domain that lacks metal chelating cysteines and histidines. Like the RING finger, the U-box is thought to form a structure consisting of three beta-sheets and a single alpha-helix, which would be stabilized by salt bridges instead of chelated metal ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  #              # #  #  #                                                    
1WGM_A        24 LDPIMStlmcdp--vvlpsSRVTVDrSTIARhlls--------------------------------------------- 56
2C2V_S         7 CGKISFelmre---pcitpSGITYDrKDIEEhlqr--------------------------------------------- 38
4WZ2_A        30 LCPISKtlikt---pvitaQGKVYDqEALSNflia--------------------------------------------- 61
4WZ3_B       131 LCPISKtlikt---pvitaQGKVYDqEALSNflia--------------------------------------------- 162
4XI1_A        30 LCPISKtlikt---pvitaQGKVYDqEALSNflia--------------------------------------------- 61
gi 74735248   45 CCCLSLqpchd---pvvtpDGYLYErEAILEyilhqkkeiarqmkayekqrgtrreeqkelqraasqdhvrgflekesai 121
gi 74754297  339 VCKISGdvmnennppmmlpNGYVYGyNSLLSirqd--------------------------------------------- 373
gi 229463016 409 ICPITRelmkd---pviasDGYSYEkEAMENwisk--------------------------------------------- 440
gi 569437747  86 ICPLSKsimkd---pviasNGITYDrSSIMNlykni-------------------------------------------- 118
gi 40882163  256 IDDISFqvmvd---pvmtkTGKSYErASIEEhlrr--------------------------------------------- 287
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                       #  # 
1WGM_A        57 ------------------------------------------------------------dqtDPFNR 64
2C2V_S        39 -----------------------------------------------------------vghfNPVTR 47
4WZ2_A        62 ------------------------------------------------------------tgnKDETG 69
4WZ3_B       163 ------------------------------------------------------------tgnKDETG 170
4XI1_A        62 ------------------------------------------------------------tgnKDETG 69
gi 74735248  122 vsrplnpftakalsgtspddvqpgpsvgppskdkdkvlpsfwipsltpeakatklekpsrtvtCPMSG 189
gi 74754297  374 -----------------------------------------------------------dkvvCPRTK 382
gi 229463016 441 -----------------------------------------------------------kkrtSPMTN 449
gi 569437747 119 -----------------------------------------------------------pdypSLMTN 127
gi 40882163  288 ------------------------------------------------------------setDPLTR 295

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