Conserved Protein Domain Family

cd16454: RING-H2_PA-TM-RING 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in the PA-TM-RING ubiquitin ligase family
The PA-TM-RING family represents a group of transmembrane-type E3 ubiquitin ligases, which has been characterized by an N-terminal transient signal peptide, a PA (protease-associated) domain, a TM (transmembrane) domain, as well as a C-terminal C3H2C3-type RING-H2 finger domain. It includes RNF13, RNF167, ZNRF4 (zinc and RING finger 4), GRAIL (gene related to anergy in lymphocytes)/RNF128, RNF130, RNF133, RNF148, RNF149 and RNF150 (which are more closely related), as well as RNF43 and ZNRF3 which have substantially longer C-terminal tail extensions compared with the others. PA-TM-RING proteins are expressed at low levels in all mammalian tissues and species, but they are not present in yeast. They play a common regulatory role in intracellular trafficking/sorting, suggesting that abrogation of their function may result in dysregulation of cellular signaling events in cancer.
PSSM-Id: 319368
View PSSM: cd16454
Aligned: 27 rows
Threshold Bit Score: 65.0157
Threshold Setting Gi: 74761852
Created: 21-May-2015
Updated: 18-Aug-2016
Aligned Rows:
RING-H2 fingerZn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: RING-H2 finger (C3H2C3-type) [structural motif], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
  • Comment:consensus: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, X is any amino acid and the number of X residues varies in different fingers.
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
Feature 1         #  #              # #  #   #             #  # 
2ECT_A        17 ECPVCKedyalgesvrqLPCNHLFHd-sCIVPWLeq---hDSCPVCR 59
gi 328850009 228 TCAICMdsindpsdlikLSCNHLFHaegCIIPWIer---nPSCPVCR 271
gi 220969357 410 SCSICLddyelgeqlrvLPCQHTFHf-nCIAPWLte--rsPTCPLCK 453
gi 300143388 362 DCPICLeeigr--tsllLPCRHGFHk-eCIEPWIer---sNHCPCCR 402
gi 159465513 327 TCSVCLdqvgdgqmvttLPCLHQFHs-aCINPWLrhkglhASCPLCK 372
gi 123479438 170 VCSICLeefnendevviLPCKHGFHe-pCLQPWLkm---hSECPSCR 212
gi 484857541 182 TCSICLctftnyskvlsLLCTHYFHs-kCIIPWIkk---hKQCPCCR 224
gi 168036736   4 DCPVCLekflagqgllaLPCNHRFHp-nCLIPWLeg---hEQCPYCR 46
gi 569426880 133 TCSICLddfetgqlvkvLACLHGFHv-nCIDPWLat--ssEFCPVCK 176
gi 558599129   3 QCSICFealss--nisqLTCSHIFHk-nCIQPWIne---nSSCPICR 43

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap