2LXP,4LAD,2LXH


Conserved Protein Domain Family
RING-H2_AMFR

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cd16455: RING-H2_AMFR 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in autocrine motility factor receptor (AMFR) and similar proteins
AMFR, also known as AMF receptor, or RING finger protein 45, or ER-protein gp78, is an internalizing cell surface glycoprotein localized in both plasma membrane caveolae and the endoplasmic reticulum (ER). It is involved in the regulation of cellular adhesion, proliferation, motility and apoptosis, as well as in the process of learning and memory. AMFR also functions as a RING finger-dependent ubiquitin protein ligase (E3) implicated in degradation from the ER. AMFR contains an N-terminal RING-H2 finger and a C-terminal ubiquitin-associated (UBA)-like CUE domain.
Statistics
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PSSM-Id: 319369
View PSSM: cd16455
Aligned: 23 rows
Threshold Bit Score: 85.884
Threshold Setting Gi: 910758523
Created: 26-Jan-2015
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2LXP; Homo sapiens AMFR (also known as ubiquitin ligase GP78) binds two Zn2+ through its RING-H2 finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
Feature 1          #  #           # #  #  #          #  #    
2LXP_C        13 DDCAICWDSMqaARKLPCGHLFHNSCLRSWLEQDtSCPTCRMSL 56
gi 360043104 415 LICAICWDVMtsWRRLPCRHDFHEHCLRAWLEQNpSCPTCRRDL 458
gi 443696081 336 DDCAVCWEKMdtARKLPCGHLFHNACLRSWLEQDaSCPTCRTSL 379
gi 198420240 420 DQCAICWEQMetARKLPCGHFFHSPCLRSWLEQDtTCPTCRKQL 463
gi 919084106 354 DKCAICWEKMksGRTLPCGHIFHSFCLRSWLEQDvSCPTCREAL 397
gi 390370495  51 DDCAICWEELkgARKLPCNHLFHDACLRSWLEHEtSCPTCRQSL 94
gi 321464375 349 NKCAICWEAAavARRLPCGHHFHHGCLLHWLEQDpTCPTCRRQL 392
gi 761905965 312 ETCAICWEKMntARQLPCGHVFHFGCLRSWLEQDpVCPTCRQTL 355
gi 196004494 257 QKCAICWEKLesARKLPCTHLFHSSCLQSWLEQDtTCPTCRLSL 300
gi 762093667 350 DNCAVCWERMdsARKLPCGHFFHNSCLTSWLEQDtSCPTCRTSL 393

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