Conserved Protein Domain Family
RING-H2_BRAP2

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cd16457: RING-H2_BRAP2 
RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins
BRAP2, also known as impedes mitogenic signal propagation (IMP), RING finger protein 52, or renal carcinoma antigen NY-REN-63, is a novel cytoplasmic protein interacting with the two functional nuclear localization signal (NLS) motifs of BRCA1, a nuclear protein linked to breast cancer. It also binds to the SV40 large T antigen NLS motif and the bipartite NLS motif found in mitosin. BRAP2 serves as a cytoplasmic retention protein and plays a role in in the regulation of nuclear protein transport. It contains an N-terminal RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), followed by a C3H2C3-type RING-H2 finger and a UBP-type zinc finger.
Statistics
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PSSM-Id: 319371
View PSSM: cd16457
Aligned: 40 rows
Threshold Bit Score: 61.5276
Threshold Setting Gi: 262111091
Created: 6-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF24 (2EP4) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1          #  #                          # #  #  #                #  #  
gi 296434410 262 PKCTVCLERMDes-----------vnGILTTLCNHSFHSQCLQRWDDt--------TCPVCRY 305
gi 307108520 284 PTCPVCLERLDeh-----------isGIVTTVCNHRFHNECLRQWGDt--------SCPVCRY 327
gi 158282095 153 PTCPVCLERLDeh-----------vsGIVTTVCTHMFHSECLQKWADs--------TCPVCRY 196
gi 220973225 358 HQCPVCLEKMTlpsvtstsdsaaassSILTTVCNHSFHIDCLARWQDs--------PCPVCRY 412
gi 693498533  97 PTCPVCLDRLDad-----------asGIATTICDHTFHAACLERWADa--------SCPVCRH 140
gi 754342517 482 PTCPVCLERLDes-----------asGIFTTICNHNFHCTCLSRWGDs--------SCPICRH 525
gi 761913691 235 PSCPVCLEKLDe--------------SVLTILCNHSFHTDCITRWEDs--------TCPVCRY 275
gi 358337244 166 PSCPVCLERLDepv----------qgILTTILCNHSFHDECIARVEDi--------TCPVCRY 210
gi 470511570 226 PTCPVCLDRLDts-----------vtGILTTVCNHTFHCLCLSKWRDsscpseslwICLICGH 277
gi 857977759 124 VSCPVCLDSIDgh------------gGSISILCRHQFHYRCLRKWKDhs------nVCPVCRY 168

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