Conserved Protein Domain Family
RING-H2_BRAP2

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cd16457: RING-H2_BRAP2 
RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins
BRAP2, also known as impedes mitogenic signal propagation (IMP), RING finger protein 52, or renal carcinoma antigen NY-REN-63, is a novel cytoplasmic protein interacting with the two functional nuclear localization signal (NLS) motifs of BRCA1, a nuclear protein linked to breast cancer. It also binds to the SV40 large T antigen NLS motif and the bipartite NLS motif found in mitosin. BRAP2 serves as a cytoplasmic retention protein and plays a role in the regulation of nuclear protein transport. It contains an N-terminal RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), followed by a C3H2C3-type RING-H2 finger and a UBP-type zinc finger.
Statistics
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PSSM-Id: 438121
Aligned: 37 rows
Threshold Bit Score: 61.1492
Created: 6-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #                                                                          
Q7Z569        262 PKCTVCLERMDes------------------------------------------------------------------- 274  human
CBY19618      188 PACTICLERMDes------------------------------------------------------------------- 200  Oikopleura di...
EED91556      358 HQCPVCLEKMTlpsvtsts------------------------------------------------------------- 376  Thalassiosira...
Q95QN6        258 PTCAVCLERMDd-------------------------------------------------------------------- 269  Caenorhabditi...
XP_005996459  271 PKCTVCLERMDes------------------------------------------------------------------- 283  coelacanth
XP_007900456  272 PPCIVCLERMDes------------------------------------------------------------------- 284  elephant shark
GAA55637      166 PSCPVCLERLDepv------------------------------------------------------------------ 179  Clonorchis si...
A0CRQ4        569 GSCPICMEDIQpsk------------------------------------------------------------------ 582  Paramecium te...
CEO96308      124 VSCPVCLDSIDgh------------------------------------------------------------------- 136  Plasmodiophor...
XP_002368120  509 EFCAVCLERVQiptapvapalpaslgppsnpiaflqaretddesqesqggrlaagasgcspplasnpaftapalcaaggg 588  Toxoplasma go...
Feature 1                                                            # #  #  #          #  #  
Q7Z569        275 -------------------------------------------vnGILTTLCNHSFHSQCLQRWDDt--TCPVCRY 305  human
CBY19618      201 -------------------------------------------vkSVLTVLCNHSFHSQCLKKWEDs--TCPVCRF 231  Oikopleura dioica
EED91556      377 --------------------------------------dsaaassSILTTVCNHSFHIDCLARWQDs--PCPVCRY 412  Thalassiosira pse...
Q95QN6        270 ---------------------------------------------SVLAILCNHSFHARCLEQWADn--TCPVCRY 298  Caenorhabditis el...
XP_005996459  284 -------------------------------------------vnGVLTTLCNHSFHSQCLQRWEDt--TCPVCRY 314  coelacanth
XP_007900456  285 -------------------------------------------vnGVLTILCNHSFHSQCLQHWEDt--TCPVCRY 315  elephant shark
GAA55637      180 -------------------------------------------qgILTTILCNHSFHDECIARVEDi--TCPVCRY 210  Clonorchis sinensis
A0CRQ4        583 -------------------------------------------epNDVQLDCKHQFHFDCIKRWLQtqkNCPICKN 615  Paramecium tetrau...
CEO96308      137 --------------------------------------------gGSISILCRHQFHYRCLRKWKDhsnVCPVCRY 168  Plasmodiophora br...
XP_002368120  589 aggnagnplsvstsdlpfslgegslssavekgvggaqgghaalpgVAVTVLCGHSFHSSCLRKWSDp--SCPVCRY 662  Toxoplasma gondii...

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