Conserved Protein Domain Family
RING-H2_Dmap_like

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cd16458: RING-H2_Dmap_like 
RING finger, H2 subclass, found in defective in mitotic arrest proteins (Dmap) and similar proteins
The subfamily includes one Schizosaccharomyces pombe protein Dma1 (SpDma1p), two Saccharomyces cerevisiae proteins, Dma1 (ScDma1p) and Dma2 (ScDma2p), and their homologs from fungi. SpDma1p was originally isolated as multicopy suppressor of the temperature-sensitive growth phenotype caused by cdc16 mutations. It functions to prevent mitotic exit and cytokinesis during spindle checkpoint arrest by inhibiting septation initiation network (SIN) signaling. ScDma1p and ScDma2p, also known as checkpoint forkhead associated with RING domains-containing protein 1 and 2 respectively, seem to be functionally redundant. They are involved in proper septin ring positioning and cytokinesis. The simultaneous lack of Dma1 and Dma2 leads to spindle mispositioning and defects in the spindle position checkpoint. All members in this family contain a forkhead-associated domain (FHA) and a C3H2C3-type RING-H2 finger, the latter suggesting they may possibly possess E3 ubiquitin-ligase activities.
Statistics
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PSSM-Id: 319372
View PSSM: cd16458
Aligned: 5 rows
Threshold Bit Score: 97.9487
Threshold Setting Gi: 1723482
Created: 27-May-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF25 (5D1K) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
Feature 1          #  #              # #  #  #                #  # 
gi 1730767   431 EDCSICLckikpcQAIFISPCAHSWHFRCVRRLVml---sYPQFVCPNCR 477
gi 1723482   190 PECCICLmpvlpcQALFVAPCSHSYHYKCIRPTLne---sHPYFSCFICR 236
gi 731703    325 EDCSICLnkikpcQAIFISPCAHSWHFHCVRRLVim---nYPQFMCPNCR 371
gi 759210526 361 GECSICLgsvlpcQALFVAPCAHVWHYKCIRPLLegknstYPQFQCPNCR 410
gi 751021804 157 PDCCICLfplaiaQSLFVSPCSHSFHFKCIRPLIea---hYPSFSCPLCR 203

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