Conserved Protein Domain Family
RING-H2_DZIP3

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cd16460: RING-H2_DZIP3 
RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
DZIP3, also known as RNA-binding ubiquitin ligase of 138 kDa (RUL138) or 2A-HUB protein, is an RNA-binding E3 ubiquitin-protein ligase that interacts with coactivator-associated arginine methyltransferase 1 (CARM1) and acts as a transcriptional coactivator of estrogen receptor (ER) alpha. It is also a histone H2A ubiquitin ligase that catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for repressing a specific chemokine gene expression program, critically modulating migratory responses to Toll-like receptors (TLR) activation. DZIP3 contains a C3H2C3-type RING-H2 finger at the C-terminus.
Statistics
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PSSM-Id: 319374
View PSSM: cd16460
Aligned: 4 rows
Threshold Bit Score: 102.411
Threshold Setting Gi: 632956513
Created: 6-Jan-2016
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Mus musculus RNF126 (2ECT) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
Feature 1            #  #             # #  #  #          #  # 
gi 50400482   1146 EPCVICHENLspenlsvLPCAHKFHAQCIRPWLMQQGTCPTCR 1188
gi 632956513   937 EPCVICHEEFssesilaLPCAHKFHSQCIGPWLKEQRTCPTCR 979
gi 115497364   957 EPCVICHENLspdnlsvLPCAHKFHSQCIRPWLIQQGTCPTCR 999
gi 1008784716 1140 EPCVICHENVspenlsvLPCAHKLHSQCIRPWLMQQRTCPTCR 1182

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