2EP4


Conserved Protein Domain Family
RING-H2_RNF24_like

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cd16469: RING-H2_RNF24_like 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
The family includes RNF24, RNF122, and similar proteins. RNF24 is an intrinsic membrane protein localized in the Golgi apparatus. It specifically interacts with the ankyrin-repeats domains (ARDs) of TRPC1, ?3, ?4, ?5, ?6, and ?7, and affects TRPC intracellular trafficking without affecting their activity. RNF122 is a RING finger protein associated with HEK 293T cell viability. It is localized to the endoplasmic reticulum (ER) and the Golgi apparatus, and overexpressed in anaplastic thyroid cancer cells. RNF122 functions as an E3 ubiquitin ligase that can ubiquitinate itself and undergoes degradation through its RING finger in a proteasome-dependent manner. Both RNF24 and RNF122 contain an N-terminal transmembrane domain and a C-terminal C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319383
View PSSM: cd16469
Aligned: 8 rows
Threshold Bit Score: 85.1971
Threshold Setting Gi: 229293659
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-H2 finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2EP4; Homo sapiens RNF24 binds two Zn2+ ions through its RING-H2 finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
Feature 1          #  #              # #  #  #          #  #    
2EP4_A        16 ELCAVCLEDFKpRDELGICPCKHAFHRKCLIKWLEVRkvCPLCNMPV 62
gi 198432473  80 ETCPVCLEDFKkKEVLAICPCHHVFHKKCLCKWLELRptCPMCMSHI 126
gi 229293659  51 KTCAVCLEDFKlMEEIGLCPCGHAFHRKCISKWLEIRntCPMCNSQV 97
gi 110816410  91 QTCAVCLEDFKgKDELGVLPCQHAFHRKCLVKWLEVRcvCPMCNKPI 137
gi 168229236  88 QPCAVCLEEFKtRDELGVCPCSHTFHKKCLLKWLEIRsvCPMCNKPI 134
gi 919068805  59 DVCPVCLDEFKlKEKIALCLCRHAFHLKCLLQWLEQRnsCPMCNTQV 105
gi 908435040  61 DTCSVCLEEFKkGEKIAVCTCRHGFHSKCLEQWLEHKnnCPLCKAPV 107
gi 156228501  82 DMCTICLEDFInKEEVNMCKCGHAYHNKCIMKWLEVRnsCPICQRGL 128

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