5D1K,5D1L,5D1M


Conserved Protein Domain Family
RING-H2_RNF25

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cd16470: RING-H2_RNF25 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins
RNF25, also known as AO7, is a putative E3 ubiquitin-protein ligase that was initially identified as an interacting protein with an ubiquitin-conjugating enzyme, Ubc5B. It is ubiquitously expressed in various tissues and predominantly localized in the nucleus. RNF25 activates the nuclear factor (NF)-kappaB-dependent gene expression upon stimulation with Interleukin-1 beta (IL-1beta), or tumor necrosis factor (TNF), or overexpression of NF-kappaB-inducing kinase. It interacts with the p65 transactivation domain (TAD) and modulates its transcriptional activity. RNF25 contains an N-terminal RWD domain, a C3H2C3-type RING-H2 finger, and a C-termial Pro-rich region. Both the RING-H2 finger and the C-terminal regions of RNF25 are necessary for the transcriptional activation.
Statistics
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PSSM-Id: 319384
View PSSM: cd16470
Aligned: 22 rows
Threshold Bit Score: 81.6668
Threshold Setting Gi: 71994745
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #  #                     # #  #  #                                            #
5D1K_B          9 QCVICLYGFqek-------eaFTKTPCYHYFHCHCLARYIQHmeqelkaqgqeqeqe--------rqhattkqkavgvqC 73
gi 30695166   120 DCPLCLYPLfpedggskqmpfMKLMSCFHCFHCECIIRWWNWlhaqeeadsksgdtlhmrrgstaregnsgsadkslgnC 199
gi 159884065  121 QCVVCLYGFadg-------deFTRTECFHYLHSYCLARHLNAlrrnyqeefdklp-----------awlqktadpfqalC 182
gi 190581998  134 KCAICLRHFmda-------snFIKTDCYHYFHNACIMRYKRHqddnn----------------------------eellC 178
gi 198416971  128 PCPVCLLSFqad-------ddFLKSPCFHHFHDHCLLQYYNHyhsnieyfqtstnpid------gppkkksevppgqvpC 194
gi 405957445  826 PCTICYEHFheg-------eeFTKTHCYHYFHCHCLARYVRHvlasiqqenqsrp-----------thqqddggqtkvpC 887
gi 585675355   32 HCAVCLYGFseg-------dsFTKTQCFHYFHSYCLAMHLITtekhfieeqeklp------------twqksttgfqasC 92
gi 675388416  132 ECAICLYGFnee-------dvFTRTECYHYFHSHCLARYSKNalenndkste------------------agasnfqllC 186
gi 761903364  149 RCPICQYDFqdd-------dqFVRTECYHYFHPNCLSRYVDLhleslakqkeesskl-------kyrlpftetlaqkleC 214
gi 780072600  138 PCTICQCLFees-------avFTKTSCYHYFHSFCLAQYLKYtekde---------------------------eedpkC 183

                  ....*
Feature 1           #  
5D1K_B         74 PVCRE 78
gi 30695166   200 PVCRK 204
gi 159884065  183 PVCRE 187
gi 190581998  179 PICRE 183
gi 198416971  195 PICRE 199
gi 405957445  888 PVCRE 892
gi 585675355   93 PVCRE 97
gi 675388416  187 PMCRV 191
gi 761903364  215 PVCRV 219
gi 780072600  184 PVCRE 188

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