Conserved Protein Domain Family
RING-H2_RNF32

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cd16471: RING-H2_RNF32 
RING finger, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
RNF32 is mainly expressed in testis spermatogenesis, most likely in spermatocytes and/or in spermatids, suggesting a possible role in sperm formation. RNF32 contains two C3H2C3-type RING-H2 fingers separated by an IQ domain of unknown function. Although the biological function of RNF32 remains unclear, the protein with double RING-H2 fingers may act as a scaffold for binding several proteins that function in the same pathway.
Statistics
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PSSM-Id: 319385
View PSSM: cd16471
Aligned: 5 rows
Threshold Bit Score: 67.2455
Threshold Setting Gi: 74717970
Created: 15-Apr-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF25 (5D1K) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  #                         # #  #  #                                       # 
gi 74717970  292 ECSICLAPLsaaggqrvgagrrsremALLSCSHVFHHACLLALEEFsvgdr----------------------ppfhaCP 349
gi 74717970  126 PCPICKEEFelr------------pqVLLSCSHVFHKACLQAFEKFtnk---------------------------ktCP 166
gi 754342151 122 ACPVCLDEFdqd------------slARTECFHAFHTHCFESYLAArherrqelsrevinhwekvpellqvddvsqtqCP 189
gi 734546909 119 VCPICLNDFtsh-----------qpsVRTHCDHYIHQPCFATYIDYsrseiqrelsewp-------ddmkdkvdqalrCP 180
gi 294882315 114 SCSICREPFrdt------------sqLILACTHSFHQRCFLSYLHYagse-------------------------tskCP 156

                 ...
Feature 1         # 
gi 74717970  350 LCR 352
gi 74717970  167 LCR 169
gi 754342151 190 VCR 192
gi 734546909 181 MCR 183
gi 294882315 157 MCR 159

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