1X4J,4V3K


Conserved Protein Domain Family
RING-H2_RNF38_like

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cd16472: RING-H2_RNF38_like 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
The family includes RING finger proteins RNF38, RNF44, and similar proteins. RNF38 is a nuclear E3 ubiquitin protein ligase that plays a role in regulating p53. RNF44 is an uncharacterized RING finger protein that shows high sequence similarity with RNF38. Both RNF38 and RNF44 contain a coiled-coil motif, a KIL motif (Lys-X2-Ile/Leu-X2-Ile/Leu, X can be any amino acid), and a C3H2C3-type RING-H2 finger. In addition, RNF38 harbors two potential nuclear localization signals.
Statistics
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PSSM-Id: 319386
View PSSM: cd16472
Aligned: 11 rows
Threshold Bit Score: 85.9946
Threshold Setting Gi: 806394279
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
Feature 1            #  #              # #  #  #          #  # 
1X4J_A         23 QTLCVVCMCDFEsrqlLRVLPCNHEFHAKCVDKWLkanrtCPICR 67
gi 74758994   377 QTLCVVCFSDFEarqlLRVLPCNHEFHTKCVDKWLkanrtCPICR 421
gi 390355528  459 QTCCVVCMSDFEtrqtLRVLPCSHEFHARCVDKWLksnrtCPICR 503
gi 734558757  410 EKVCVVCQCDFEkrdhVRVLPCDHHYHVKCVDKWLktnrtCPICR 454
4V3K_C         24 QTLCVVCMCDFEsrqlLRVLPCNHEFHAKCVDKWLkanrtCPICR 68
gi 934162771  562 QTMCVICMYEFEakqnLRVLPCHHEFHVRCIDKWLktnrtCPICR 606
gi 919092876  564 QTSCVVCMCDFEqkqqLRVLPCSHEFHIKCVDKWLksnrtCPICR 608
gi 190582664  478 SKGCVICMSDFEdidcLRVLMCKHEFHTSCIDRWLktnrtCPICR 522
gi 24645397   769 QSSCVVCMCDFElrqlLRVLPCSHEFHAKCVDKWLrsnrtCPICR 813
gi 291229977  505 QTCCVVCMCDFEqrqlLRVLTCNHEFHTKCVDKWLktnrtCPICR 549
gi 405967974 1758 QTSCVVCMCDFEnrqlLRVLPCSHEFHAKCVDKWLktnrtCPICR 1802

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