Conserved Protein Domain Family
RING-H2_RNF103

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cd16473: RING-H2_RNF103 
RING finger, H2 subclass, found in RING finger protein 103 (RNF103) and similar proteins
RNF103, also known as KF-1, or zinc finger protein 103 homolog (Zfp-103), is an endoplasmic reticulum (ER)-resident E3 ubiquitin-protein ligase that is widely expressed in many different organs, including brain, heart, kidney, spleen, and lung. It is involved in the ER-associated degradation (ERAD) pathway through interacting with components of the ERAD pathway, including Derlin-1 and VCP. RNF103 contains several hydrophobic regions at its N-terminal and middle regions, as well as a C-terminal C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319387
View PSSM: cd16473
Aligned: 20 rows
Threshold Bit Score: 83.4962
Threshold Setting Gi: 780106038
Created: 6-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens AMFR (2LXP; also known as ubiquitin ligase GP78) binds two Zn2+ through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
Feature 1         #  #              # #  #  #            #  #   
gi 51701715  620 ECVVCLENFengcllmgLPCGHVFHQNCIVMWLag-grHCCPVCRWP 665
gi 213410433 183 LCVVCLENYqgndfiriLPCGHIFHAHCLDIWMtr-tfANCPLCKAD 228
gi 672283640 511 RCAICMDAYregaslryLPCFHTYHQACIDVWLsq--nGRCPICKEN 555
gi 780106038 332 ACPVCMDDYdeeaelrrLPCFHVYHKKCIDMWLnknqdPVCPICRVE 378
gi 443719888 619 ECAICLESYksgvllcgLPCHHSFHHYCIMGWLtr-dnHCCPVCRWP 664
gi 321477238 341 DCAICLDKYrvtvdvcgLPCGHQFHHDCIMVWLqr-dnHHCPICRWP 386
gi 291239583 530 ECAICLESYdtesilcgLPCYHTYHHQCIVVWLhg--hHCCPICRWP 574
gi 459172286 489 SCSICLDNYkqhdhvcgLPCGHVFHHSCILSWLhs-dqHCCPICRWP 534
gi 675386757 179 ECSICLESYrygeilcgLPCGHNFHMNCIMSWLsr-dnHCCPICRWP 224
gi 646696174 625 ECAVCLESYrwgtilcgLPCGHNYHQCCIMEWLgr-dnHHCPVCRWP 670

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