2KIZ,5D0I,5D0K


Conserved Protein Domain Family
RING-H2_RNF111_like

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cd16474: RING-H2_RNF111_like 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
The family includes RING finger proteins RNF111, RNF165, and similar proteins. RNF111, also known as Arkadia, is a nuclear E3 ubiquitin-protein ligase that targets intracellular effectors and modulators of transforming growth factor beta (TGF-beta)/Nodal-related signaling for polyubiquitination and proteasome-dependent degradation. It also interacts with the clathrin-adaptor 2 (AP2) complex and regulates endocytosis of certain cell surface receptors, leading to modulation of epidermal growth factor (EGF) and possibly other signaling pathways. The N-terminal half of RNF111 harbors three SUMO-interacting motifs (SIMs). It thus functions as a SUMO-targeted ubiquitin ligase (STUbL) that directly links nonproteolytic ubiquitylation and SUMOylation in the DNA damage response, as well as triggers degradation of signal-induced polysumoylated proteins, such as the promyelocytic leukemia protein (PML). RNF165, also known as Arkadia-like 2, or Arkadia2, or Ark2C, is an E3 ubiquitin ligase with homology to C-terminal half of RNF111. It is expressed specifically in the nervous system, and can serve to amplify neuronal responses to specific signals. It thus acts as a positive regulator of bone morphogenetic protein (BMP)-Smad signaling that is involved in motor neuron (MN) axon elongation. Both RNF165 and RNF111 contain a C-terminal C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319388
View PSSM: cd16474
Aligned: 18 rows
Threshold Bit Score: 74.6553
Threshold Setting Gi: 428174163
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-H2 finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
Feature 1           #  #              # #  #  #           #  #   
2KIZ_A         15 EKCTICLSILeegEDVRRLPCMHLFHQVCVDQWLi-tNKKCPICRVD 60
gi 443722532  257 ERCTICLSDFedsDEVRRLPCMHLFHIGCVDTWLs-sNRRCPICRVD 302
gi 391342339  110 VRCSICLTDYeveEEVRRLPCMHLFHAACIDQWFr-aDKRCPMCRVD 155
gi 449017510  290 PICTICLSQYepaEEIRKLPCGHHFHRACVDQWLlffDKSCPQCRSD 336
gi 443723425  213 LTCKICLSEFedkEEVRRLPCLHQYHTACIDEWLr-mKAQCPTCRCD 258
gi 919053151 1016 EKCTICLSELeedEDVRRLPCMHLFHIECVDQWLv-tNKRCPICRVD 1061
gi 873233354 3311 EPCSICLTDYnkgDEVRQLPCCHFFHVTCVDQWLa-lHLDCPLCKGN 3356
gi 934145938  192 DVCCICLERFnssITVRRLPCLHLFHCKCIDKWLn-kNRKCPICRIM 237
gi 21356709  1185 EKCAICLNLFeieNEVRRLPCMHLFHTDCVDQWLv-tNKHCPICRVD 1230
gi 428174163   27 TECCICLCEYdvgEKLRKLPCLHRFHSVCVDRWLl-sNKMCPICKES 72

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