Conserved Protein Domain Family
RING-H2_TRAIP
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cd16480: RING-H2_TRAIP 
RING finger, H2 subclass, found in TRAF-interacting protein (TRAIP) and similar proteins
TRAIP, also known as RING finger protein 206 (RNF206) or TRIP, is a ubiquitously expressed nucleolar E3 ubiquitin ligase important for cellular proliferation and differentiation. It is found near mitotic chromosomes and functions as a regulator of the spindle assembly checkpoint. TRAIP interacts with tumor necrosis factor (TNF)-receptor-associated factor (TRAF) proteins and inhibits TNF-alpha-mediated nuclear factor (NF)-kappaB activation. It also interacts with two tumor suppressors CYLD and spleen tyrosine kinase (Syk), and DNA polymerase eta, which facilitates translesional synthesis after DNA damage. TRAIP contains an N-terminal C3H2C2-type RING-H2 finger and an extended coiled-coil domain.
Links
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Statistics
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PSSM-Id: 438143
Aligned: 10 rows
Threshold Bit Score: 82.0893
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                 # #  #  #            #  # 
Q9BWF2         6 LCTICSDFFdh---srDVAAIHCGHTFHLQCLIQWFetapsRTCPQCR 50  human
NP_001084838   6 YCTICSDFFdn---trDVAAITCGHTFHQECLLQWFhsaphRTCPQCR 50  African clawed frog
NP_991170      6 YCTICSDFFdn---skDVAAIHCGHTFHYSCLLQWFqsapnKTCPQCR 50  zebrafish
NP_001025757   6 HCTICSDFFdn---arDVAAVPCGHTFHRACLFQWFdtapsRTCPQCR 50  chicken
XP_007888466   6 YCTICSDFFdn---irDVAAIHCGHTFHNECLAHWFhtapsRTCPQCR 50  elephant shark
XP_006002702   6 YCTICSDFFdn---trDVAAIHCGHTFHYECLIQWFqsapcRTCPQCR 50  coelacanth
NP_569969      7 ICTICSERFrt---sdNIQAGSCGHAFHEDCLDHWRkq--sRTCPICR 49  fruit fly
KOF74790       4 YCVICSDRFvstggewDIAAGICGHTFHSACLGTWLet--sRTCPTCR 49  Octopus bimaculoides
NP_001261071   5 NCVICAELFgq---adEVFATVCGHMFHHNCLNQWLdr--sKTCPQCR 47  fruit fly
NP_611303     31 LCAICNEFFran--diIFSTSRCGHVFHKDCLTRWLnr--sRTCPQCR 74  fruit fly

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