Conserved Protein Domain Family
RING-H2_TRAIP

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cd16480: RING-H2_TRAIP 
RING finger, H2 subclass, found in TRAF-interacting protein (TRAIP) and similar proteins
TRAIP, also known as RING finger protein 206 (RNF206) or TRIP, is a ubiquitously expressed nucleolar E3 ubiquitin ligase important for cellular proliferation and differentiation. It is found near mitotic chromosomes and functions as a regulator of the spindle assembly checkpoint. TRAIP interacts with tumor necrosis factor (TNF)-receptor-associated factor (TRAF) proteins and inhibits TNF-alpha-mediated nuclear factor (NF)-kappaB activation. It also interacts with two tumor suppressors CYLD and spleen tyrosine kinase (Syk), and DNA polymerase eta, which facilitates translesional synthesis after DNA damage. TRAIP contains an N-terminal C3H2C2-type RING-H2 finger and an extended coiled-coil domain.
Statistics
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PSSM-Id: 319394
View PSSM: cd16480
Aligned: 7 rows
Threshold Bit Score: 83.3729
Threshold Setting Gi: 918301163
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF24 (2EP4) binds two Zn2+ ions through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
Feature 1         #  #                 # #  #  #            #  # 
gi 30580637    6 LCTICSDFFdh---srDVAAIHCGHTFHLQCLIQWFetapsRTCPQCR 50
gi 148222677   6 YCTICSDFFdn---trDVAAITCGHTFHQECLLQWFhsaphRTCPQCR 50
gi 45387641    6 YCTICSDFFdn---skDVAAIHCGHTFHYSCLLQWFqsapnKTCPQCR 50
gi 71895473    6 HCTICSDFFdn---arDVAAVPCGHTFHRACLFQWFdtapsRTCPQCR 50
gi 632946251   6 YCTICSDFFdn---irDVAAIHCGHTFHNECLAHWFhtapsRTCPQCR 50
gi 556999358   6 YCTICSDFFdn---trDVAAIHCGHTFHYECLIQWFqsapcRTCPQCR 50
gi 918301163   4 YCVICSDRFvstggewDIAAGICGHTFHSACLGTWLet--sRTCPTCR 49

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