Conserved Protein Domain Family
RING-H2_UBR3

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cd16483: RING-H2_UBR3 
RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins
UBR3, also known as N-recognin-3, E3alpha-III, or zinc finger protein 650, is an E3 ubiquitin-protein ligase targeting the essential DNA repair protein APE1, also known as Ref-1, for ubiquitylation. It regulates cellular levels of APE1 and is required for genome stability. It also plays a regulatory role in sensory pathways, including olfaction. Moreover, in Drosophila, UBR3 regulates apoptosis by controlling the activity of Drosophila inhibitor of apoptosis protein 1 (DIAP1), which is required to prevent caspase activation. UBR3 contains an N-terminal ubiquitin-recognin (UBR) box, a C3H2C3-type RING-H2 finger, and a C-terminal UBR-specific autoinhibitory (UAIN) domain.
Statistics
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PSSM-Id: 319397
View PSSM: cd16483
Aligned: 16 rows
Threshold Bit Score: 118.631
Threshold Setting Gi: 808355372
Created: 24-Mar-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens Pirh2 (2JRJ) binds two Zn2+ through its RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #  #                                                                          
gi 166214992 1234 YDCVICGQSgpsSEDRPTGLVVLLQ--ASSVLGQCrdnvepkklpiseeeqiypwdtcaa-------------------- 1291
gi 405957399 1121 YDCVICGTTsasTADKTMGLVVLLQ--PSSVLGHRlqendvislplkkdqkvyphvscas-------------------- 1178
gi 443721346 1243 FDCCICNQStasTDQRLVGLVANLQ--STSILGNRrhatdavhlplrepegtrgtcaed--------------------- 1299
gi 442615442 1513 YDCIICNCTtpsTESNPIGLVVLVE--SSGIVGHRrriaerlplpinaedesrlahttrla------------------- 1571
gi 215503943  169 YECIICSQTsssTEDRPIGMVVLLQ--ATSVLGHAqeaeeearklpctdeerlllledssr------------------- 227
gi 551642834 1120 VKCVICSLYaspSTSEPVGLVCFMEnsNVFAKHHRrarekffggrlq--------------------------------- 1166
gi 156389374   56 FECVICGEAspsTEERPVGLVALLQ--SSAVLRHRsrhhakipctesetthaencgta---------------------- 111
gi 779986535 1451 YECVICGQTspsTATKPIGQVVLMQ--ATNVLGHRclsdqriplpigedtsltsmgrcwreemqrlstlldsfgkddmes 1528
gi 919076722  993 YDCVICNQTtpsTPDRPVGMVALLQ--ATSVLGHRrqveevrtmptseeemrqvrestncg------------------- 1051
gi 321477872  679 YDCVICNQAspsTSDRPMCLVVLLQ--ATSVLAHKrywpsgsslalpvceedrfnldkvdsl------------------ 738
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 166214992 1292 -----------------------------------------------------vhdvrlsllqryfkdsscllavsiGWE 1318
gi 405957399 1179 -----------------------------------------------------vqrqqlktmfehfeesscqlsvniGWE 1205
gi 443721346 1300 ------------------------------------------------------fhnrftslvqefeetscllsvniGWR 1325
gi 442615442 1572 ----------------------------------------------------aefnrrtellslkfgdeswylsnnmAYD 1599
gi 215503943  228 ---------------------------------------------------aahmklrfdglarhfddhswsqsvniGWE 256
gi 551642834 1167 -----------------------------------------------------------------gggaevatnmqvHSS 1181
gi 156389374  112 ------------------------------------------------------erqrmdaltqcftkeasmrassvGAD 137
gi 779986535 1529 mdrmicrnamkllrqdrissavillghrclndqriplpvgedtsltsmgrcwreemqrlstlldsfgkersweaagtGWE 1608
gi 919076722 1052 ----------------------------------------------------qvqaqrlrkmvtyfeessclqsmniGWE 1079
gi 321477872  739 ---------------------------------------------------hvemnrrvenlrqhfdesswltslniGYE 767
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                # #  #  #                                  #  #         
gi 166214992 1319 GGVYVQTCGHTLHIDCHKSYMeslrndqv---------lqgfsvdkGEFTCPLCRQFANSVLP 1372
gi 405957399 1206 GGVVVHTCGHYLHLDCHSSYLlslrtqem---------tgnlavnkGEYWCPLCRQLANSVIP 1259
gi 443721346 1326 GGVHAQTCGHYVHLDCLALYIeslktqsq---------sqsirvgdGEFWCPTCRNLSNTALP 1379
gi 442615442 1600 NGVHVQSCGHHVHLSCLEAYLktlyttq-----------rqpvqdrGEFYCPVCRQLSNSVLP 1651
gi 215503943  257 GGVHVQSCGHYIHVDCHKSYMlsqkqsqr---------lqtvaverGEYWCPLCRQLANSVLP 310
gi 551642834 1182 PNLFFQSCGHYIHVSCFNSYLdslshpeknaslltrtnlgyqeaknGNFFCPLCRQMANALVP 1244
gi 156389374  138 GGIHIQTCGHYLHIDCQQSYLrslqlhqm----------hsfnsrnGEFTCPLCRQLGNCVLP 190
gi 779986535 1609 GGVHIQTCGHSLHLDCHQAYLtslrghnyq-------ahdldvrrrGEFQCPLCRQLANSVLP 1664
gi 919076722 1080 GGVAAQTCGHYLHIDCHGSYMesviqdrnl--------ahglvvykGEYWCPLCRQLANAVFP 1134
gi 321477872  768 GGVYVHTCGHYLHLDCHKQYLqslrsqqr---------qqslnverGEYSCPLCRQLANSALP 821

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