Conserved Protein Domain Family
mRING-H2-C3H2C2D_ZSWM2

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cd16486: mRING-H2-C3H2C2D_ZSWM2 
Modified RING finger, H2 subclass (C3H2C2D-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
ZSWIM2, also known as MEKK1-related protein X (MEX) or ZZ-type zinc finger-containing protein 2, is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis through Fas, death receptor (DR) 3 and DR4 signaling. ZSWIM2 is self-ubiquitinated and targeted for degradation through the proteasome pathway. It also acts as an E3 ubiquitin ligase, through the E2, Ub-conjugating enzymes UbcH5a, UbcH5c, or UbcH6. ZSWIM2 contains four putative zinc-binding domains including an N-terminal SWIM (SWI2/SNF2 and MuDR) domain critical for its ubiquitination, and two modified RING-H2 fingers separated by a ZZ zinc finger domain, which was required for interaction with UbcH5a and its self-association. This family corresponds to the second RING-H2 finger, which is not a canonical C3H2C3-type, but a modified C3H2C2D-type.
Statistics
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PSSM-Id: 319400
View PSSM: cd16486
Aligned: 25 rows
Threshold Bit Score: 63.7849
Threshold Setting Gi: 42572629
Created: 6-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
modified
Feature 1: modified RING-H2 finger (C3H2C2D-type) [structural motif], 8 residue positions
Conserved feature residue pattern:C C C H H C C DClick to see conserved feature residue pattern help
Evidence:
  • Comment:consensus of the canonical C3H2C3-type RING-H2 finger: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, X is any amino acid and the number of X residues varies in different fingers.
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
  • Comment:ZSWM2 contains two modified RING-H2 fingers. One of RING fingers found in ZSWM2 and some homologs is modified as C3H2C2D-type, rather than the canonical C3H2C3-type RING-H2 finger.
  • Comment:putative Zn2+ binding sites

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
Feature 1         #  #               # #  #  #           #  # 
gi 313104068 343 QCLLCLKAFhlGQHTRLLP-CTHKFHRKCIDNWLFHkcnsCPIDG 386
gi 19114241  204 FCIICYADYafDDILRVLP-CEHVFHTQCIDTWMTTmkasCPLCN 247
gi 955348381 139 ECLVCLGEFqqEESLRVLPkCNHAFHVPCVDTWLRShk-tCPLCR 182
gi 116790621 241 TCAICLEDYkaGDKLRILP-CHHKFHLLCIDSWLTMwrtfCPVCK 284
gi 302771708  23 TCAICLEDYiaDEKLRVLP-CQHEFHATCVDHWLTTrrsfCPICK 66
gi 527316009 581 NCAICIEDFvpTALVRLLP-CGHVFHRTCIDSWFTRst-lCPLCL 623
gi 196014201  27 LCPVCLDEFvaGDVLRILP-CKHEFHKTCVDSWLENkq-tCPLCK 69
gi 919077325 287 TCAVCLDVFlhRQKIRVLP-CYHEFHTKCVDTWLIKnr-tCPLCK 329
gi 926766544  48 CCVVCLDEFeeGDMVRELP-CHHLFHVDCVDTWLKThs-tCPVCR 90
gi 780177140 331 SCAVCLEEFfkGQTIRMLP-CHHTFHNRCVDSWLIRkr-tCPLCK 373

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