Conserved Protein Domain Family
RING-CH-C4HC3_LTN1

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cd16491: RING-CH-C4HC3_LTN1 
RING-CH finger, H2 subclass (C4HC3-type), found in E3 ubiquitin-protein ligase listerin and similar proteins
Listerin, also known as RING finger protein 160 or zinc finger protein 294, is the mammalian homolog of yeast Ltn1. It is widely expressed in all tissues, but motor and sensory neurons and neuronal processes in the brainstem and spinal cord are primarily affected in the mutant. Listerin is required for embryonic development and plays an important role in neurodegeneration. It also functions as a critical E3 ligase involving quality control of nonstop proteins. It mediates ubiquitylation of aberrant proteins that become stalled on ribosomes during translation. Ltn1 works with several cofactors to form a large ribosomal subunit-associated quality control complex (RQC), whick mediates the ubiquitylation and extraction of ribosome-stalled nascent polypeptide chains for proteasomal degradation. It appears to first associate with nascent chain-stalled 60S subunits together with two proteins of unknown function, Tae2 and Rqc1. Listerin contains a long stretch of HEAT (Huntingtin, Elongation factor 3, PR65/A subunit of protein phosphatase 2A, and TOR) or ARM (Armadillo) repeats in the N terminus and middle region, and a catalytic RING-CH finger, also known as vRING or RINGv, with an unusual arrangement of zinc-coordinating residues in the C-terminus . Its cysteines and histidines are arranged in the sequence as C4HC3-type, rather than the C3H2C3-type in canonical RING-H2 finger.
Statistics
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PSSM-Id: 319405
View PSSM: cd16491
Aligned: 40 rows
Threshold Bit Score: 81.9403
Threshold Setting Gi: 75027612
Created: 31-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-CH finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens FANCL (4CCG) binds two Zn2+ ions through its RING-CH finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
Feature 1           #  #               #  #    #  #            #  # 
gi 313104324 1713 EDCMICFSVIHgfnysLPKKACRTCKKKFHSACLYKWFTSSnksTCPLCR 1762
gi 2497203   1506 EECAICYSILHavdrkLPSKTCPTCKNKFHGACLYKWFRSSgnnTCPLCR 1555
gi 74626848  1556 EECAICYSVLSve-rtLPNKRCGTCRHKFHASCLYKWFKSSnssRCPLCR 1604
gi 409047006 1757 SECAICYSMISamdgsLPKKPCKTCKNKFHSGCLYKWFNSShssSCPLCR 1806
gi 452825162  575 EECPICYSILHisngtLPRLECVTCKHKFHAACLYKWLQSSatsSCPLCR 624
gi 358341078 1792 EECAICYSVVHntnfsLPKMQCHTCRKLFHYACMYRWFTTSrnpACPLCR 1841
gi 470319449 1589 VACHICFSIISvqdrsLPSKKCAICKNKFHSGCLYKWFKTSnasKCPLCR 1638
gi 326427005 1580 EECTVCFSIVHgtnyqLPTIKCPTCRKLFHADCIARWFSSSgnnTCPMCR 1629
gi 749718591 1574 EKCHICFSVLSstdlgVPSKKCIVCQKKFHKTCLVQWFVSSvkkSCPLCR 1623
gi 75006600  1393 EDCTICMMTVHqqthqLPKIKCKQCKNKFHSNCLYKWFESSnqsTCPLCR 1442

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