Conserved Protein Domain Family
RING-CH-C4HC3_ZSWM2

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cd16494: RING-CH-C4HC3_ZSWM2 
RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
ZSWIM2, also known as MEKK1-related protein X (MEX) or ZZ-type zinc finger-containing protein 2, is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis through Fas, death receptor (DR) 3, and DR4 signaling. ZSWIM2 is self-ubiquitinated and targeted for degradation through the proteasome pathway. It also acts as an E3 ubiquitin ligase, through the E2, Ub-conjugating enzymes UbcH5a, UbcH5c, or UbcH6. ZSWIM2 contains four putative zinc-binding domains including an N-terminal SWIM (SWI2/SNF2 and MuDR) domain critical for its ubiquitination and two RING fingers separated by a ZZ zinc finger domain, which was required for interaction with UbcH5a and its self-association. This model corresponds to the first RING finger, which is a C4HC3-type RING-CH finger, also known as vRING or RINGv, rather than the canonical C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 438157
Aligned: 29 rows
Threshold Bit Score: 72.7492
Created: 27-May-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of human FANCL with bound Zn2+ ions through its RING-CH finger
  • Comment:RING-CH finger (C4HC3-type)
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
  • Comment:The RING fingers found in MARCH proteins have an unusual arrangement of zinc-coordinating residues: The conserved helix complete with tryptophan at the C-terminal end is present but the cysteines and histidines are arranged in the sequence as C4HC3-type, rather than the typical C3H2C3-type in RING-H2 finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #  #                 #   #    #  #                 #  #    
Q8NEG5        144 EDICSICQELLlek----klPVTFCRfGCGNSIHIKCMKILANYQstsntsmLKCPLCRKEF 201  human
KDR21261      285 EELCPICLLEMvd-----geSLVVCItGCRNKLHHHCMAIWAEECyqq-serVLCPLCRHSW 340  Zootermopsis nevadensis
KPM45935      232 EGDCPICYCELdgg----seGVVWCRaACGQNIHEHCFKMWARTKqg----dVTCPLCRSVW 285  Neonectria ditissima
KJE96356      882 ETTCAICLAEFne-----aeDFTWCRnGCGNVLHTHCMTVWAIDLtrr-sdvVVCPFCRSDW 937  Capsaspora owczarzaki ATCC 30864
XP_018096467  370 EQMCPICLLGMld-----eeSLTVCEeGCRNKLHHHCMSIWAEECrrn-resLICPLCRSKW 425  African clawed frog
XP_013063027  385 EEICPICLLEMle-----geSLICCDnGCHNRLHHHCIAIWFEECrrq-ndpLNCPLCRAQW 440  Biomphalaria glabrata
PSC74169      260 EGDCPVCFDEMeas----geAVSWCL-ACGNNIHRSCMQHWASSKraq-rsdVTCPLCRAPW 315  Micractinium conductrix
RPD80277      211 EDDCPICYENMhre---aesKLTFCE-DCGNGLHKVCFQQWANAAkn----gITCVFCRAKW 264  Lentinus tigrinus ALCF2SS1-7
XP_001745619  143 EEGCPICLVQVve-----geSATRCA-TCRNAIHLHCMTVLAHGCrai-gkqTSCPICRSEW 197  Monosiga brevicollis MX1
OSX70200      181 EDDCPICYEAFgevassddpAVVYCRrGCGGGVHADCHKRWKDSSpg----pLTCVYCRAPW 238  laver

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