Conserved Protein Domain Family
RING-CH-C4HC3_ZSWM2

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cd16494: RING-CH-C4HC3_ZSWM2 
RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
ZSWIM2, also known as MEKK1-related protein X (MEX) or ZZ-type zinc finger-containing protein 2, is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis through Fas, death receptor (DR) 3, and DR4 signaling. ZSWIM2 is self-ubiquitinated and targeted for degradation through the proteasome pathway. It also acts as an E3 ubiquitin ligase, through the E2, Ub-conjugating enzymes UbcH5a, UbcH5c, or UbcH6. ZSWIM2 contains four putative zinc-binding domains including an N-terminal SWIM (SWI2/SNF2 and MuDR) domain critical for its ubiquitination and two RING fingers separated by a ZZ zinc finger domain, which was required for interaction with UbcH5a and its self-association. This family corresponds to the first RING finger, which is a C4HC3-type RING-CH finger, also known as vRING or RINGv, rather than the canonical C3H2C3-type RING-H2 finger.
Statistics
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PSSM-Id: 319408
View PSSM: cd16494
Aligned: 27 rows
Threshold Bit Score: 65.7863
Threshold Setting Gi: 15220091
Created: 27-May-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-CH finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens FANCL (4CCG) binds two Zn2+ ions through its RING-CH finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
Feature 1            #  #              #   #    #  #                 #  #    
gi 313104068  144 EDICSICQELLlek-klPVTFCRfGCGNSIHIKCMKILANYQstsntsmLKCPLCRKEF 201
gi 218512139  440 EQMCPICLLGMld--eeSLTVCEdGCRNKLHHHCMSIWAEECrrn-repLICPLCRSKW 495
gi 847089397  377 EQMCPICLLGMld--eeSLTVCEeGCRNKLHHHCMSIWAEECrrn-repLICPLCRAKW 432
gi 159479854  145 DDPCPICYEDMvgqdpdMLVWCRfGCGRNVHGKCMGVWMEHQvqslgkeLTCPLCRSDW 203
gi 568028502  143 GEVCAICQEDMdd--skPLTFCRkGCGNNFHIECMKVFGESRrqs-kenIICPLCRQDW 198
gi 646718990  285 EELCPICLLEMvd--geSLVVCItGCRNKLHHHCMAIWAEECyqq-serVLCPLCRHSW 340
gi 954198588  181 DALCPICQDDLke--dqALTFCRkQCGNNFHIKCMIVWVKHKlnggdekIPCPMCRTDL 237
gi 955179575  146 DDTCPICCDDIhe--drALVYCRfGCGNNIHSACFKQYATHNstn-pspLLCPLCREQW 201
gi 936417714  232 EGDCPICYCELdgg-seGVVWCRaACGQNIHEHCFKMWARTKqg----dVTCPLCRSVW 285
gi 765555852  882 ETTCAICLAEFne--aeDFTWCRnGCGNVLHTHCMTVWAIDLtrr-sdvVVCPFCRSDW 937

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