2D8S,2M6M


Conserved Protein Domain Family
RING_CH-C4HC3_MARCH

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cd16495: RING_CH-C4HC3_MARCH 
Click on image for an interactive view with Cn3D
RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH proteins (MARCH)
The family corresponds to a novel family of membrane-associated E3 ubiquitin ligases, consisting of 11 members in mammals (MARCH1-11), which are characterized by containing an N-terminal C4HC3-type RING-CH finger, also known as vRING or RINGv, a variant of C3H2C3-type RING-H2 finger). Most family members have hydrophobic transmembrane spans and are localized to the plasma membrane and intracellular organelle membrane. Only MARCH7 and MARCH10 are predicted to have no transmembrane spanning region. MARCH proteins have been implicated in mediating the ubiquitination and subsequent down-regulation of cell-surface immune regulatory molecules, such as major histocompatibility complex class II and CD86, as well as in endoplasmic reticulum-associated degradation, endosomal protein trafficking, mitochondrial dynamics, and spermatogenesis.
Statistics
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PSSM-Id: 319409
View PSSM: cd16495
Aligned: 57 rows
Threshold Bit Score: 51.9444
Threshold Setting Gi: 42569605
Created: 29-Mar-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-CH finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2D8S; Homo sapiens MARCH8 binds two Zn2+ ions through its RING-HC finger.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #  #                         # #       #  #            #  # 
2D8S_A        18 CRICHcegd------------despLITPCHCTGSLHfVHQACLQQWIkssdtrcCELCK 65
gi 75219829   74 CRVCLqdke-------------evlIELGCQCRGGLAkAHRSCIDAWFrtkgsnqCEICQ 120
gi 75309116   81 CRICHlplet----------nnglpLQLGCSCKGDLGvAHSKCAETWFkikgnmtCEICG 130
gi 75309929  249 CRICMvemee-----------deeaFKMECMCKGELAlAHKTCTIKWFtikgnitCDVCK 297
gi 19074333   15 CKICHtgdi------------rgdeLCNPCRCSGTIKyIHRECLMSWMecsgtkkCDICH 62
gi 148909535  75 CRICQeede-------------drsMEIPCACSGSMKyAHRKCVQRWCnekgdttCEICQ 121
gi 159478986  38 CRICLeeda-------------lrnLEVPCACAGTSKyAHHECIQRWInekgnlrCEICD 84
gi 307106838 153 CLICLeeftqee-------fingaaLRLECNCRGDLAlRHRECIMKWVqvkgsnvCELCK 205
gi 302775346 132 CRICQqhae-------------eplIELGCHCRGELSrAHRSCIEQWFgnkgtnkCEICQ 178
gi 42569605  102 CRICHfgsdqspeasgddksvspelIEIGCKCKNELGlAHFHCAEAWFklrgnsvCEICG 161

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