Conserved Protein Domain Family
RING-HC_BAR

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cd16497: RING-HC_BAR 
RING finger, HC subclass, found in bifunctional apoptosis regulator (BAR)
BAR, also known as RING finger protein 47, was originally identified as an inhibitor of Bax-induced apoptosis. It participates in the block of apoptosis induced by TNF-family death receptors (extrinsic pathway) and mitochondria-dependent apoptosis (intrinsic pathway). BAR is predominantly expressed by neurons in the central nervous system and is involved in the regulation of neuronal survival. It is an endoplasmic reticulum (ER)-associated RING-type E3 ubiquitin ligase that interacts with BI-1 protein and post-translationally regulates its stability as well as functions in ER stress. BAR contains an N-terminal C3HC4-type RING-HC finger, a SAM domain, a coiled-coil domain, and a C-terminal transmembrane (TM) domain. This family corresponds to the RING-HC finger responsible for the binding of ubiquitin conjugating enzymes (E2s).
Statistics
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PSSM-Id: 319411
View PSSM: cd16497
Aligned: 12 rows
Threshold Bit Score: 91.3997
Threshold Setting Gi: 919010092
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens RNF168 (3L11) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
Feature 1           #  #           # #  #  #              #  #    
gi 74753089    32 FSCHCCYDILvnPTTLNCGHSFCRHCLALWWas--skKTECPECREKW 77
gi 147898835   29 FSCHCCYDILvnPTTLNCGHSFCRHCLALWWvs--skKTECPECRNTW 74
gi 483501015   33 FHCHCCYDILvnPTTLNCGHSFCRHCLALWWvs--skKNECPECREKW 78
gi 47218918    36 FFCHCCYDVLvnPTTLTCGHSFCRHCLALWWes--srKNECPECREKW 81
gi 72009491    80 FSCACCYELMvqPTTLNCGHSFCRLCLARWWkt--sqKTTCPECRQPW 125
gi 632976139   37 FSCHCCYDILvnPTTLNCGHSFCRHCLALWWda--srKTECPECREKW 82
gi 557018584   39 FSCHCCYDILvnPTTLNCGHSFCRHCLALWWes--skKLECPECREKW 84
gi 585674352   57 FNCGCCYELMvqPTTLNCGHSFCRLCLARWWki--snNTTCPGCRQQW 102
gi 919010092   22 FNCPVCFEMLidPTTLNCGHNLCRHCLAQWYla--gqRQSCPVCQQAW 67
gi 556104683   24 FLCSCCFNLMtqPTSLMCGHNFCRGCLARWFlt--srKRECPTCRQKW 69
gi 340368677   94 MSCGVCFQLLldPVTLNCGHSFCLVCLAQLWnvsrnsSLLCPMCRQPW 141
gi 999983618 1190 FHCGCCYELMvdPTTLNCGHSFCRFCLAQWWhs--skKTTCPECRQSW 1235

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