1JM7


Conserved Protein Domain Family
RING-HC_BRCA1

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cd16498: RING-HC_BRCA1 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
BRCA1, also known as RING finger protein 53 (RNF53), is a RING finger protein encoded by tumor suppressor gene BRCA1 that regulates all DNA double-strand break (DSB) repair pathways. BRCA1 is frequently mutated in in patients with hereditary breast and ovarian cancer (HBOC). Its mutation is also associated with an increased risk of pancreatic, stomach, laryngeal, fallopian tube, and prostate cancer. It plays an important role in the DNA damage response signaling and has been implicated in various cellular processes such as cell cycle regulation, transcriptional regulation, chromatin remodeling, DNA DSBs, and apoptosis. BRCA1 contains an N-terminal C3HC4-type RING-HC finger, and two BRCT (BRCA1 C-terminus domain) repeats at the C-terminus.
Statistics
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PSSM-Id: 319412
View PSSM: cd16498
Aligned: 14 rows
Threshold Bit Score: 71.2789
Threshold Setting Gi: 443721344
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
Feature 1               #  #           # #  #  #              #  # 
1JM7_A         18 MQKILECPICLELIKePVSTKCDHIFCKFCMLKLLnqkk-gpsqCPLCK 65
gi 45383782    18 MQKNLECPVCLDVIKePVSTKCDHVFCRFCMFKLLsrkkkgviqCPLCK 66
gi 15991720    18 MQKNLECPICLELMKePVATKCDHIFCKFCMLQLLskkkkgtvpCPLCK 66
gi 556108543    1 MTKNLECSICLELLKnPVSTKCEHQFCRFCIIQFLnkkr--svpCPLCK 47
gi 728984      18 MQKILECPICLELIKePVSTKCDHIFCKFCMLKLLnqkk-gpsqCPLCK 65
gi 585690463   19 MRKNLECPICLDLLKdPVTTRCSHQFCRFCITEFFkgts--sapCPLCK 65
gi 40747978    16 LWETLQCPICLDLMSePVSTKCDHQFCRFCMLKLLsntkqnkanCPVCK 64
gi 919076708   23 MQKSLECSICLELMKnPVSTKCDHQFCRFCVTEYLrnkp--sapCPLCK 69
gi 443721344   18 LQKTFECPICLDLMKnAVSTKCDHKFCRLCIQKAIghks--sipCPICK 64
gi 514701341   11 VSKALECGICKDVLKqPQRTRCNHVYCKFCILKHLelsk-skcrCPLCK 58

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