Conserved Protein Domain Family
RING-HC_CARP

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cd16500: RING-HC_CARP 
RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins
The CARPs family includes CARP-1 and CARP-2 proteins, both of which are E3 ubiquitin ligases that ubiquitinate apical caspases and target them for proteasome-mediated degradation. As a novel group of caspase regulators with a FYVE-type zinc finger domain, they do not localize to membranes in the cell and are involved in the negative regulation of apoptosis, specifically targeting two initiator caspases, caspase 8, and caspase 10. Moreover, they stabilize MDM2 by inhibiting MDM2 self-ubiquitination, as well as by targeting 14-3-3sigma for degradation. They work together with MDM2 enhancing p53 degradation, thereby inhibiting p53-mediated cell death. CARPs contain an N-terminal FYVE-like domain that can serve as a membrane-targeting or endosome localizing signal and a C-terminal C3HC4-type RING-HC finger domain.
Statistics
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PSSM-Id: 319414
View PSSM: cd16500
Aligned: 24 rows
Threshold Bit Score: 69.7838
Threshold Setting Gi: 675862104
Created: 3-May-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens Parkin (5C1Z) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30
                 ....*....|....*....|....*....|....*....
Feature 1         #  #           # #   #  #      #  #   
gi 74760679  324 LCRICMDavIDCVLLECGHMVTCTKCGKRMsECPICRQY 362
gi 340374665 240 LCKICMDepVDCVLLECGHMLSCVKCGRKLsECPVCRQF 278
gi 215497742 296 LCKICMEgcVDCVILDCGHMCTCTQCGKQLsECPICRQY 334
gi 156223759 255 SCKVCMDnlIDCVLLECGHMVACINCSKQLaECPICRQN 293
gi 405960323 351 LCKICMDaaINCVLLECGHMVTCTQCGRRLaECPICRQN 389
gi 190581643 297 LCKICMDapITCVLLECGHMVTCTKCGKRLaECPICRQY 335
gi 699249548 294 FCKICWErpRDCVLLECAHMSTCITCGKQLrECPICRQH 332
gi 675862104  96 LCKVCMEnvIDCVLLECGHMAVCKYCGKQMaECPICRKY 134
gi 24653236  652 LCKICMDapIECVFLECGHMATCTSCGKVLnECPICRQY 690
gi 443709377 235 LCKICMDaiIDCVLLECGHMVTCTKCGRRMaECPICRQY 273

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