4A49,1FBV,3ZNI


Conserved Protein Domain Family
RING-HC_Cbl_like

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cd16502: RING-HC_Cbl_like 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in Casitas B-lineage lymphoma (Cbl) proteins
The Cbl adaptor proteins family contains a small class of RING-type E3 ubiquitin ligases with oncogenic activity, which is represented by three mammalian members, c-Cbl, Cbl-b and Cbl-c, as well as two invertebrate Cbl-family proteins, D-Cbl in Drosophila and Sli-1 in C. elegans. Cbl proteins function as potent negative regulators of various signaling cascades in a wide range of cell types. They play roles in ubiquitinating the activated tyrosine kinases and targeting them for degradation. D-Cbl associates with the Drosophila epidermal growth factor receptor (EGFR) and overexpression of D-Cbl in the eye of Drosophila embryos inhibits EGFR dependent photoreceptor cell development. Sli-1 is a negative regulator of the Let-23 receptor tyrosine kinase, an EGFR homolog, in vulva development. Cbl proteins in this family consist of a highly conserved N-terminal half that includes a tyrosine-kinase-binding domain (TKB, also known as the phosphotyrosine binding PTB domain, is composed of a four helix-bundle, a Ca2+ binding EF-hand and a highly variant SH2 domain) and a C3HC4-type RING-HC finger, both of which are required for Cbl-mediated downregulation of RTKs, and a divergent C-terminal region.
Statistics
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PSSM-Id: 319416
View PSSM: cd16502
Aligned: 20 rows
Threshold Bit Score: 84.3285
Threshold Setting Gi: 374074630
Created: 2-May-2013
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding siteRING-HC finger
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
Feature 1            #  #           # #  #  #                 #  # 
4A49_A         27 FQLCKICAENDKDvKIEPCGHLMCTSCLTSWqes------egqGCPFCR 69
1FBV_A        332 FQLCKICAENDKDvKIEPCGHLMCTSCLTSWqes------egqGCPFCR 374
gi 7505920    387 FELCKICDDNEKNiKIEPCGHLLCAKCLANWqdsd----gggnTCPFCR 431
gi 163775898  342 FEVCKICNSNFKSvRIDPCGHLLCHQCLRKWidssntptssatTCPFCR 390
gi 761907861  339 FQMCKICAENDKDvKLEPCGHLICHVCLQSWles------graDCPFCR 381
gi 125987803  348 FELCKICAESNKDvKIEPCGHLLCSCCLAAWqhs------dsqTCPFCR 390
gi 190586126  373 FELCKICAARNKDaYLEPCGHLMCEQCLQRWqlk------ggqECPFCR 415
gi 360045066  332 FELCKICDENNKDtRLEPCGHLICKNCLFNCqstg-----nglTCPFCR 375
gi 906959500  275 FELCKICTANPKDvQIEPCGHLICHSCVSEWqkq------aknECPFCR 317
gi 828214365  366 FQLCKICAENDKDtKIEPCGHLVCHLCLQHWqeg-------gqGCPFCR 407

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