Conserved Protein Domain Family
RING-HC_COP1

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cd16504: RING-HC_COP1 
RING finger, HC subclass, found in constitutive photomorphogenesis protein 1 (COP1) and similar proteins
COP1, also known as RING finger and WD repeat domain protein 2 (RFWD2) or RING finger protein 200 (RNF200), was defined as a central regulator of photomorphogenic development in plants, which targets key transcription factors for proteasome-dependent degradation. It is localized predominantly in the nucleus, but may also be present in the cytosol. Mammalian COP1 functions as an E3 ubiquitin-protein ligase that interacts with Jun transcription factors and modulates their transcriptional activity. It also interacts with and negatively regulates the tumor-suppressor protein p53. Moreover, COP1 associates with COP9 signalosome subunit 6 (CSN6), and is involved in 14-3-3 delta ubiquitin-mediated degradation. The CSN6-COP1 link enhances ubiquitin-mediated degradation of p27(Kip1), a critical CDK inhibitor involved in cell cycle regulation, to promote cancer cell growth. Furthermore, COP1 functions as the negative regulator of ETV1 and influences prognosis in triple-negative breast cancer. COP1 contains an N-terminal extension, a C3HC4-type RING-HC finger, a coiled coil domain, and seven WD40 repeats. In human COP1, a classic leucine-rich NES, and a novel bipartite NLS is bridged by the RING-HC finger.
Statistics
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PSSM-Id: 319418
View PSSM: cd16504
Aligned: 26 rows
Threshold Bit Score: 61.1202
Threshold Setting Gi: 428175777
Created: 9-Dec-2015
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens BRCA1 (1JM7) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
Feature 1            #  #           # #  #  #          #  #    
gi 55976539  132 NDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEdnNRCPKCNYVV 177
gi 828228734  86 NDITCPVCFEVIKEPYVTKCGHNFCFNCIKTSLEvsNRCPQCKFVI 131
gi 675881670  31 DCYSCPICFNILDEPYMTKCGHSFCYRCIGHSLEndNRCPKCGFII 76
gi 321456923 115 SDLLCPVCLDMMSEPYVTTCGHSFCHGCIVRSLElaSKCPKCSGPL 160
gi 545704722  29 KLVECPICFTTLKDSFVTPCQHTFCYECISKHLEtkSSCPSCGRYL 74
gi 760445717  19 ADFSCPVCREVMRSPCVTPCGHTFCHACILRHVQrdSTCPCCRSYL 64
gi 168027087  44 KDFLCPICFQPMEDAFLTSCGHSFCYSCITTHLNnrNNCPNCARYL 89
gi 20141387   48 KDLLCPICMQIIKDAFLTACGHSFCYMCIITHLRnkSDCPCCSQHL 93
gi 281205537 160 DTLSCPICLDIIKEPFITKCGHSFCYQCILVQLSkqSSCPLCMHFL 205
gi 569341748  27 DTEECPVCTEVMEDPFITPCKHLFCFGCISAWVHqtRSCPLCRSEI 72

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