Conserved Protein Domain Family
RING-HC_CYHR1

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cd16505: RING-HC_CYHR1 
RING finger, HC subclass, found in cysteine and histidine-rich protein 1 (CYHR1) and similar proteins
CYHR1, also known as cysteine/histidine-rich protein (Chrp), shows sequence similarity with the Drosophila RING finger protein Seven-in-Absentia (sina) and its murine and human siah homologs. It is a novel prognostic marker that may work as a therapeutic target in patients with esophageal squamous cell carcinoma. It is also a biomarker of the response to erythropoietin in hemodialysis patients. CYHR1 contains an N-terminal C3HC4-type RING-HC finger and a C-terminal tumor necrosis factor (TNF) receptor associated factor (TRAF)-like substrate-binding domain (SBD).
Statistics
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PSSM-Id: 319419
View PSSM: cd16505
Aligned: 15 rows
Threshold Bit Score: 82.5251
Threshold Setting Gi: 675367224
Created: 31-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens Parkin (5C1Z) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
Feature 1           #  #          #   #  #  #                #  # 
gi 123905342  79 VLCCTVCLDLPKasvYQCTNGHLMCAGCFIHLLADSRLKEEqATCPNCR 127
gi 182641965  69 VLCCAVCLDLPKasvYQCTNGHLMCAGCFIHLLADARLKEEqATCPNCR 117
gi 443682893  41 ILCCAVCLDLPKvavYQCTNGHLMCAGCLAHLLADARLKDEeATCPNCR 89
gi 321479257  58 ILCCSVCLDLPSsavYQCSNGHLSCVGCFNHLLADARMRDEtATCPNCR 106
gi 72016517   54 ILCCTVCLDLPTftiYQCNNGHLMCAGCFTHLLADSRLKDEqPTCPNCR 102
gi 585672513  29 ILCCAVCLDLPRstvFQCTNGHLMCAGCFTHLLADARLKNEqATCPNCR 77
gi 193788588  44 ILSCTVCLDLPTsacMQCCHGHLMCVGCYHHLLADARLKDEqATCPSCR 92
gi 675376704  56 ILCCAVCLDLPKssvYQCRNGHLVCSDCFNHLLADAQLRMGtAVCPSCR 104
gi 524890841  52 ILCCAVCLDLPKt-cYQCSNGHLMCAGCFNHLLADARIKDEtATCPNCR 99
gi 75027766  110 ALCCAVCLDLPKtamYQCQMGHLMCAACFTHLLADGRLRDQiATCPNCR 158

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