Conserved Protein Domain Family

cd16507: RING-HC_GEFO_like 
RING finger, HC subclass, found in Dictyostelium discoideum Ras guanine nucleotide exchange factor O (RasGEFO) and similar proteins
RasGEFO, also known as RasGEF domain-containing protein O, is one of the Ras guanine-nucleotide exchange factors (RasGEFs), which are the proteins that activate Ras through catalyzing the replacement of GDP with GTP. They are particularly important for signaling in development and chemotaxis in many organisms, including Dictyostelium. RasGEFO contain a C3HC4-type RING-HC finger that may be responsible for the E3 ubiquitin ligase activity.
PSSM-Id: 319421
View PSSM: cd16507
Aligned: 3 rows
Threshold Bit Score: 80.3278
Threshold Setting Gi: 158274392
Created: 26-Apr-2016
Updated: 18-Aug-2016
Aligned Rows:
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
  • Comment:Based on the structural evidence that Mus musculus Hakai (3VK6) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
Feature 1         #  #            # #  #  #              #  # 
gi 74930339   15 TCGICQNLFkdPNTLIPCGHAFCLDCLTTnas-----iknCIQCK 54
gi 262095050 660 TCLQCMQLFtePMTLAPCGHTYCAACLAKcgsleapssiaCNMCE 704
gi 158274392 677 TCLMCLDIFkaPVTLIPCGHTFCRKCLANan-------glCTECG 714

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